Clinical trials: bipolar
Major Depressive Disorder, Bipolar I Disorder
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.
Depression and suicidal ideation/attempt/death are major causes of morbidity and mortality from psychiatric illnesses. In 2009, the World Health Organization listed depression as the leading cause of years lost due to disability…
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Bipolar Depression
- Trial name
- NCT02593643
- Testing
- Ketamine, Midazolam, Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bipolar Disorder
Stabilizing Mood and Sleep With Blue Blocking Eyewear in Bipolar Disorder
The study investigates whether add-on treatment with eyewear that blocks the short wavelengths of visible light (<500nm) reduces manic symptoms and improves sleep in patients receiving outpatient treatment as usual for bipolar…
- Trial name
- BLUES (NCT06271304)
- Testing
- Blue blocking eyewear, Low filtration eyewear
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
ADHD, Autism
Trial to Assess the Pharmacokinetics, Safety, Tolerability of Oral Brexpiprazole in Children (6 to <13 Years Old) With Central Nervous System Disorders
A study to assess pharmacokinetics, safety and tolerability of brexpiprazole in children ages 6 to <13 years with CNS disorders.
- Conditions
- ADHD, Autism, Bipolar I Disorder, Conduct Disorder
- Trial name
- NCT03292848
- Testing
- Brexpiprazole
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Treatment Noncompliance, Bipolar Disorder
Treatment Adherence Enhancement in Bipolar Disorder
Bipolar disorder (BD) is a serious and chronic mental illness that is associated with substantial impairment in quality of life and functional outcomes, high rates of suicide, and high financial costs.
- Trial name
- CAE RCT (NCT01542008)
- Testing
- Customized Adherence Enhancement (CAE), broadly-directed, non-individualized education (EDU)
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Case Western Reserve University
Benign Prostatic Hyperplasia
Prostate Bipolar Enucleation and Resection Versus Open Prostatectomy
Benign prostatic hyperplasia (BPH) is a frequent disease in aging men accompanied by bladder outlet obstruction (BOO). Open prostatectomy (OP) is still considered the first-line treatment for more than 80 ml prostate size.
- Trial name
- NCT05416606
- Testing
- transurethral bipolar enucleation and resection of the prostate, open surgical transvesical prostatectomy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Diabetes, Obesity
Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2
This program aims to help Veterans who take antipsychotic medications lose weight. We use a program based on the American Diabetes Association's "Diabetes Prevention Program," and we have modified it to fit the lifestyles of…
- Conditions
- Diabetes, Obesity, Weight Gain
- Trial name
- MAMAO2 (NCT01052714)
- Testing
- Lifestyle Balance
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Bipolar I Disorder
Pharmacokinetic Study of VHX-896 and Iloperidone Tablets Under Steady-State Conditions
Study to compare the pharmacokinetics and pharmacodynamics of VHX-896 and iloperidone and evaluate the safety and tolerability of VHX-896 and iloperidone in patients with schizophrenia or bipolar I disorder under steady state…
- Trial name
- NCT06494397
- Testing
- VHX-896 and iloperidone, Iloperidone and VHX-896
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Vanda Pharmaceuticals
Bipolar Disorder, Pediatric Bipolar Disorder
Retrain Your Brain in Children/Adolescents With Bipolar Disorder: A Pilot Study
The main aim of this study is to test a new, non-medication computer-based potential treatment for bipolar disorder in children and adolescents.
- Conditions
- Bipolar Disorder, Pediatric Bipolar Disorder, Childhood-onset Bipolar Disorder
- Trial name
- COGFLEX (NCT01954680)
- Testing
- COGFLEX-skill building levels, COGFLEX-control condition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Bradley Hospital
Early Psychosis, Psychosis
State Representation in Early Psychosis 2
This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants.
- Conditions
- Early Psychosis, Psychosis, Schizophrenia, Bipolar Disorder With Psychosis
- Trial name
- STEP2 (NCT07834203)
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depressive Disorder, Bipolar I and Bipolar II
Microbiome of Depression & Treatment Response to Citalopram
The purpose of this study is to evaluate the feasibility of developing a microbiome probe of depression and to evaluate the microbiome change in a preliminary analysis of treatment response (n=20) vs.
- Trial name
- NCT02330068
- Testing
- citalopram
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bipolar Disorder
Optimal Length of Treatment Continuation With Olanzapine After Remission of Manic or Mixed Episode
This is a randomized, parallel, open-label study of patients who have responded to treatment in the acute phase of their manic or mixed episode, with or without psychotic symptoms, with olanzapine in mono or co-therapy, and who…
- Trial name
- NCT00191997
- Testing
- Olanzapine
- Where
- 11 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Eli Lilly and Company
Perioperative Period
The Comparison of Conventional and Advanced Bipolar Energy Modalities During Laparoscopic Staging Surgery of Gynecologic Cancers
This single-institution prospective randomized clinical trial will be performed at the Gynecologic Oncology clinic of Ankara University.
- Trial name
- NCT02822820
- Testing
- Ligasure-Covidien, RoBi forceps-Karl Storz
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara University
Bipolar Disorder
Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients
The main goal of this study is evaluate the efficacy of memantine association on the treatment with a previous combination of two drugs, including quetiapine with lithium or quetiapine with aripiprazole in young patients with…
- Trial name
- ARIQUELI-ME (NCT02630888)
- Testing
- Memantine
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Severe Mental Illness, Schizophrenia
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study evaluates a group-based intervention designed to improve romantic and social relationship skills in adults living with a severe mental illness (SMI), such as schizophrenia, bipolar disorder, or major depressive…
- Conditions
- Severe Mental Illness, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- A2C'estMieuxVE (NCT07316803)
- Testing
- À deux, c'est mieux (Better Together) Group Intervention
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Bipolar Depression
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression
The purpose of the study is to determine the efficacy, safety and pharmacokinetics of inhaled Esketamine in participants with treatment-resistant bipolar depression (TRBD).
- Trial name
- NCT03965871
- Testing
- Esketamine DPI - low dose, Esketamine DPI - medium dose, Esketamine DPI - high dose
- Where
- 12 sites in Poland
- Volunteers
- 88 people
- Sponsor
- Celon Pharma SA
Bipolar Disorder
Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder
This study will evaluate the effectiveness of interpersonal and social rhythm therapy in treating adolescents with a bipolar spectrum disorder
- Trial name
- NCT00576355
- Testing
- Interpersonal and Social Rhythm Therapy for Adolescents (IPSRT-A), Treatment As Usual (TAU)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Washington
Bipolar Disorder
A Glutamate Transporter GLT1, in the Treatment of Bipolar Disorder
This study examines if Ceftriaxone, an antibiotic, will improve symptoms of depression in Bipolar Disorder. Purpose: This study will examine whether the drug ceftriaxone can help patients with bipolar depression during short-term…
- Trial name
- NCT00512616
- Testing
- Ceftriaxone
- Where
- United States
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar I Disorder
The Young Adult and Pediatric Bipolar Study
To examine the safety and effectiveness of extended-release carbamazepine in the treatment of children and adolescents aged 10-17 years with acute manic or mixed bipolar I disorder.
- Trial name
- NCT00350857
- Testing
- Extended-Release Carbamazepine
- Where
- 26 sites in United States
- Volunteers
- 161 people
- Sponsor
- Validus Pharmaceuticals
Psychotic Disorders, Bipolar Disorder
Honest Open Proud for Psychotic and Bipolar Disorder in Norway
The purpose of this pilot study is to evaluate the feasibility, acceptability and efficacy of a Norwegian adaptation of the group-based intervention 'Honest Open Proud' among adults with psychotic and bipolar disorders in an…
- Conditions
- Psychotic Disorders, Bipolar Disorder, Disclosure
- Trial name
- HOP-NOR (NCT06384755)
- Testing
- Honest Open Proud program
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
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