Clinical trials: bipolar
Bipolar Disorder
Reward and Punishment Sensitivity in Bipolar Disorders
Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical…
- Trial name
- Recodec-BP (NCT04237610)
- Testing
- behavioral assessment
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Psychotic Disorders, Bipolar Disorder
Comparison of Aripiprazole Versus Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI
The purpose of this study is to compare abdominal weight gain and fat distribution in people taking aripiprazole versus risperidone or quetiapine, to people not taking any of these antipsychotic medications.
- Conditions
- Psychotic Disorders, Bipolar Disorder, Metabolic Syndrome X
- Trial name
- CALM (NCT01739127)
- Testing
- Aripiprazole, Risperidone/Quetiapine
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Schizophrenia, Schizoaffective Disorder
Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs
Background: Antipsychotics can induce metabolic disorders such as obesity, hyperglycemia, dyslipidemia or metabolic syndrome. It has been observed that treatment with antipsychotic could be accompanied by a decrease in the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02986490
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Bipolar Disorder, Substance Dependence
Modifying Group Therapy for Bipolar Substance Abusers - 1
The purpose of this study is to modify Integrated Group Therapy (IGT), which is has been found successful for patients with bipolar disorder (BD) and substance use disorder(SUD), so that it can be more readily adopted by…
- Trial name
- NCT00227838
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Bipolar Disorder, Bipolar I Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
- Conditions
- Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression
- Trial name
- NCT03336918
- Testing
- Lithium
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Bipolar Depression
Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated Prolactin Release
This study will be a Proof of Mechanism (POM) study to establish evidence of central pharmacodynamic activity for PF 04455242, and will be a parallel group, randomized, double blind, sponsor open study conducted in healthy male…
- Trial name
- NCT00988949
- Testing
- PF-04455242, spiradoline
- Where
- Singapore
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Bipolar Enucleation of the Prostate
Comparative Analysis of Bipolar Enucleation of the Prostate Using Different Commercial Types of Electrodes
The goal of this randomized, prospective, multicenter clinical trial is to compare the enucleation efficacy of prostate enucleation using different commercial bipolar electrodes in male patients aged ≥50 years diagnosed with…
- Trial name
- NCT07020325
- Testing
- Bipolar Enucleation of the Prostate, Bipolar electrode From Wolf company, Bipolar electrode From Storz company
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Bipolar Disorders
Study of the Clinical Management of Bipolar Disease
This study is to provide reliable information on the management of bipolar disorders in real every day, clinical practice, to determine the clinical outcomes of such management and use of resources in relation to the disease, and…
- Trial name
- WAVE bd (NCT01062607)
- Where
- 213 sites in Austria, Belgium and 8 more
- Volunteers
- 2,965 people
- Sponsor
- AstraZeneca
Bipolar Disorder
Paliperidone Palmitate Efficacy and Safety in Bipolar Disorder Complicated by Alcoholism
The primary specific aim is to examine the efficacy of Paliperidone extended release Paliperidone Palmitate Injection (INVEGA® SUSTENNA™) compared to placebo in decreasing manic symptoms in patients with comorbid DSM-IV bipolar…
- Trial name
- NCT01211704
- Testing
- Paliperidone Palmitate
- Sponsor
- University of Miami
Bipolar Disorder, Substance Use Disorders
Post-Hospital Intervention for Veterans With Comorbid Bipolar and Substance Use Disorders
This trial aims to evaluate the effectiveness of a novel intervention for Veterans with co-occurring bipolar and substance use disorders following a psychiatric hospitalization.
- Trial name
- NCT04127604
- Testing
- Integrated Treatment Adherence Program for Veterans (ITAP-VA), Safety Assessment and Follow-up Evaluation (SAFE)
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Bipolar Disorder
Lurasidone Extended Use Study
This is an open-label continuation study designed to monitor the safety, tolerability and effectiveness of lurasidone in subjects who have completed participation in a lurasidone extension study (NCT00868959 and NCT01566162) and…
- Trial name
- NCT01485640
- Testing
- Lurasidone
- Where
- 46 sites in Canada, Colombia and 10 more
- Volunteers
- 162 people
- Sponsor
- Sumitomo Pharma America, Inc.
Bipolar Disorder
Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania
This is a study designed to evaluate the efficacy, safety, and tolerability of RGH-188 monotherapy in the treatment of acute mania.
- Trial name
- NCT00488618
- Testing
- Cariprazine (RGH-188)
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Forest Laboratories
Bipolar 1 Disorder, Control Subjects
Socio-cognitive and Biological Responses to Maltreatment
The study will investigate how a history of emotional childhood maltreatment (CM) is associated with different aspects of psychological (social behaviour, empathy) and biological (brain function and structure, inflammation)…
- Trial name
- NCT07101107
- Where
- Austria
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Bipolar Disorders, Manic Episode
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic Episodes Associated With Bipolar I Disorder
The purpose of the study is to assess the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo during 3 weeks of treatment of mania in patients with Bipolar I Disorder who are suffering a manic…
- Trial name
- NCT00257075
- Testing
- Risperidone, oral tablets
- Volunteers
- 267 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bipolar Disorder, Schizophrenia
Connectomics in Psychiatric Classification of Bipolar Disorder and Schizophrenia
Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with bipolar disorder and schizophrenia.
- Trial name
- NCT02756065
- Testing
- no intervention
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Washington University Early Recognition Center
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Bipolar I Disorder
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients
The present study aims to evaluate the efficacy and safety of 8 mg endoxifen in the study population. As endoxifen represents a totally new class of drugs in the treatment of the bipolar disorder, it is essential to compare the…
- Trial name
- NCT04315792
- Testing
- Endoxifen
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Jina Pharmaceuticals Inc.
Bipolar Depression
Carbamazepine Extended-Release for the Treatment of Bipolar Depression
To study the efficacy and safety of beaded extended-release Carbamazepine (Equetro) in the treatment of patients with Bipolar Disorder with a Major Depressive Episode.
- Trial name
- NCT00203567
- Testing
- carbamazepine ER
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Tuscaloosa Research & Education Advancement Corporation
Prostate, BPH (Benign Prostatic Hyperplasia)
Feasibility and Safety of a Single Working Element for Bipolar and Laser Enucleation in Prostate Surgery: A Prospective Study
A prospective feasibility study would be a practical first step, focusing on real-time assessment and ensuring the new working element's integration is safe and effective before broader clinical trials.
- Trial name
- NCT07020364
- Testing
- A single working element for bipolar enucleation, A single working element for laser enucleation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Psychotic Disorders
Longitudinal Multimodal Neuroimaging Studies in Patients With First Episode Psychosis
The purpose of this study is to investigate the structural, functional and chemical brain abnormalities in patients with first episode psychosis and assess the evolution of these abnormalities during the course of the disease.
- Trial name
- NCT01688765
- Testing
- Observational
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.