Clinical trials: bipolar
Bipolar Disorder
Psychoeducation Versus Cognitive-Behavioral Therapy in Bipolar Disorder
To examine the impact of cognitive-behavioural therapy on both the episodic and functional outcome of bipolar disorder, in combination with pharmacotherapy. Primary Hypothesis is twofold: 1.
- Trial name
- NCT00188838
- Testing
- Psychoeduction, Cognitive-Behavioral Therapy
- Where
- 6 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Bipolar Disorder
Effects of Electroconvulsive Therapy (ECT) in Bipolar Depression
The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure the levels of several brain chemicals including, but not limited to, glutamate, glutamine, and N-acetylaspartate, before and after…
- Trial name
- NCT01557933
- Testing
- No interventions will be used
- Sponsor
- Mclean Hospital
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bipolar Disorder
Tamoxifen in Treatment of Acute Mania
Objective: Evidence indicates that the protein kinase C-PKC signaling cascade may be one of the direct targets in treatment of mania.
- Trial name
- NCT00411203
- Testing
- Tamoxifen Citrate
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Stanley Medical Research Institute
Large Intrauterine Polyps, Smaller Type 0 and 1 Myomas
The Hysteroscopic Morcellator (HM).
Rationale: The hysteroscopic morcellator (HM) is a novel technique for removal of intrauterine polyps, myomas and placental tissue. It withholds some technical advantages over resectoscopy.
- Conditions
- Large Intrauterine Polyps, Smaller Type 0 and 1 Myomas, Residual Placental Tissue
- Trial name
- HM (NCT01537822)
- Testing
- Hysteroscopic morcellator, Resectoscope
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 253 people
- Sponsor
- University Hospital, Ghent
Thyroid Diseases
Comparing Harmonic Ultrasonic Scalpel to Small Jaw Bipolar Device in Thyroid Surgery
Energy devices are used routinely during thyroid surgery to aid surgical dissection and to stop bleeding. The newer generation energy devices have several advantages over older machines.
- Trial name
- NCT01765686
- Testing
- Harmonic Scalpel (Ethicon Endo-Surgery, USA), Ligasure Small Jaw (Covidien, USA)
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National Cancer Centre, Singapore
Bipolar Disorder (BD), Bipolar 1 Depression
Neuromodulation of Mood Switch Circuitry in Bipolar Disorder
This study is exploring a new approach to treating depression in people with bipolar disorder (BD). Investigators are testing whether a non-invasive form of brain stimulation can help us understand depressed-to-euthymic mood…
- Conditions
- Bipolar Disorder (BD), Bipolar 1 Depression, rTMS, fMRI
- Trial name
- CircuitBD (NCT07680153)
- Testing
- MagVenture MagPro TMS system
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Weill Medical College of Cornell University
Bipolar Disorder (BD), Quality of Life (QOL)
Evaluating the PolarUs App in People With Bipolar Disorder
Our team recently pilot tested a new mobile app, PolarUs, co-designed with people who live with bipolar disorder (BD), to support BD self-management and quality of life (QoL) measurement.
- Trial name
- NCT07890805
- Testing
- PolarUs Mobile App
- Where
- Canada
- Volunteers
- 504 people
- Sponsor
- University of British Columbia
Bipolar Disorder
Bioequivalency Study of 300 mg Lithium Carbonate Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane lithium carbonate 300 mg extended release tablet formulation compared to Solvay's Lithobid 300 mg extended release tablet under fed conditions using a single-dose…
- Trial name
- NCT00602394
- Testing
- Lithium
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Time Restricted Eating, Diet, Mediterranean
Healthy Lifestyles for Bipolar Disorder
The goal of this clinical trial is to compare the effects of two different healthy lifestyles on outcomes for those with bipolar disorder.
- Trial name
- HL (NCT06188754)
- Testing
- Time restricted eating, Mediterranean diet
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Berkeley
Bipolar Disorder
mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders
Veterans with bipolar disorders (BD) experience recurrent and seemingly unpredictable periods of severe impairments in psychosocial functioning, such as participation in social roles and activities.
- Trial name
- MEASURE-BD (NCT06204705)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Bipolar I Disorder
Observational Study of Oral Cariprazine Capsules to Assess Change in Disease Activity in Adult Participants With Bipolar I Disorder
Bipolar I disorder (BP-I) is a common, chronic, and disabling mental illness with significant morbidity and mortality defined by episodes of mania and depression (or symptoms of both at once, known as mixed features).
- Trial name
- CReW BP-I (NCT06256367)
- Where
- 19 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- AbbVie
Schizoaffective Disorder, Schizophrenia
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
Testing an mHealth mobile interventionist texting program on illness management.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT03062267
- Testing
- Mobile Interventionist
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Washington
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Depression, Depressive Disorder
Optimizing Electroconvulsive Therapy for Depression
This study will evaluate the effectiveness of electroconvulsive therapy (ECT) administered with medication for the treatment of a major depressive episode (unipolar or bipolar) and will compare two types of ECT.
- Conditions
- Depression, Depressive Disorder, Bipolar Disorder
- Trial name
- NCT00045916
- Testing
- High dosage electroconvulsive therapy, Nortriptyline, Venlafaxine
- Where
- 4 sites in United States
- Volunteers
- 340 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Schizoaffective Disorder
Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People
This study will evaluate the effectiveness of a health management and supported rehabilitation intervention in treating serious mental illnesses in older people.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00169052
- Testing
- Health Care Management and Supported Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Affective Disorder
Bipolar Research Study Using MR Imaging
In this proposal, the investigators will focus on subcortical gray and white matter structures commonly found to be abnormal in schizophrenia.
- Trial name
- NCT02083978
- Testing
- MRI scanning
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Washington University Early Recognition Center
Benign Prostatic Hyperplasia (BPH), Lower Urinary Tract Symptom
A Prospective Comparative Study Evaluating the Safety and Efficacy of Transurethral Thulium Fiber Laser, Holmium Laser and Bipolar Enucleation of Large Sized Prostate
This study compares the safety and efficacy of three endoscopic enucleation techniques for large prostates (>100 mL) in patients with benign prostatic hyperplasia (BPH): Thulium Fiber Laser Enucleation (ThuFLEP), Holmium Laser…
- Conditions
- Benign Prostatic Hyperplasia (BPH), Lower Urinary Tract Symptom, Bladder Outlet Obstruction
- Trial name
- NCT07627178
- Testing
- Thulium Fiber Laser Enucleation of the Prostate (ThuFLEP), Holmium Laser Enucleation of the Prostate (HoLEP), Bipolar Transurethral Enucleation of the Prostate (B-TUEP)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tanta University
Psychotic Disorders, Bipolar Disorders
A Novel Peer-Delivered Recovery-Focused Suicide Prevention Intervention for Veterans With Serious Mental Illness
Suicide is a major public health concern, particularly among Veterans with serious mental illness (SMI, i.e., psychotic disorders or bipolar disorders).
- Conditions
- Psychotic Disorders, Bipolar Disorders, Suicidal Ideation, Suicide, Attempted
- Trial name
- NCT05537376
- Testing
- SUicide Prevention by Peers Offering Recovery Tactics
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Alcohol Abuse, Schizophrenia
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community…
- Conditions
- Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- CMETG (NCT01567943)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
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