Clinical trials: cGvHD
Chronic Obstructive Pulmonary Disease
Second Follow-up Study of COPD Patients and Healthy Controls for Evaluation of Predictive Non-coding RNA Biomarkers
Between 2012 and 2014, a cohort of 90 COPD subjects of disease severity grades GOLD I-IV as well as 60 healthy control subjects (30 smokers and 30 non-smokers) have been examined regarding different clinical and blood/ sputum…
- Trial name
- Ribo III (NCT04895124)
- Where
- Germany
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Social Determinants of Health (SDOH), Hypertension
Arizona CEAL: Linking Social Care With Healthcare Systems to Address SDOH
The goal of the Arizona Community Engagement Alliance (AZ-CEAL) will be to combine social care with healthcare programs. The study will be connecting selected patients from clinics with trained community health workers (CHW) who…
- Conditions
- Social Determinants of Health (SDOH), Hypertension, Diabetes Mellitus, Hypercholesterolaemia
- Trial name
- AZCEAL (NCT07799961)
- Testing
- Community Health Worker intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Sairam Parthasarathy
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Asthma, COPD
Exhaled Breath Metabolomic Biomarkers in the Acutely Breathless Patient
An acute study carried out across three acute admissions units within Leicestershire. The study is aimed at discovery and validation of volatile organic compounds (VOCs) in exhaled breath.
- Conditions
- Asthma, COPD, Heart Failure, Community-acquired Pneumonia
- Trial name
- EMBER (NCT03672994)
- Where
- United Kingdom
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Chronic Kidney Diseases
Correlation Between Endoscopic Findings And Helicobacter Pylori Infection In Chronic Kidney Disease Patients
The aim of this study is to 1. Evaluate frequency of H. pylori infection in patients with CKD. 2. Description the gastroduodenal lesions found in patients with chronic kidney disease and correlate it to H.pylori infection.
- Trial name
- NCT05927766
- Testing
- esophagogastroduodenoscopy
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Non Specific Low Back Pain
Pulse Ultrasound and Kneading Massage in Non- Specific Chronic Low Back Pain
Back pain is one of humanity most frequent complains. About nine of ten adults experience back pain at some points in their life and five out of ten working adults have back pain every year.
- Trial name
- NSCLBP (NCT03329482)
- Testing
- PULSE ULTRASOUND, KNEADING MASSAGE
- Where
- Nigeria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University
COPD
Inflammation in COPD and the Effect of Nicotinamide Riboside
The aim of this study is to investigate if nicotinamide riboside can reduce the airways inflammation associated with chronic obstructive pulmonary disease (COPD) in patients aged 60 or older.
- Trial name
- ICON (NCT04990869)
- Testing
- Nicotinamide Riboside
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postural Tachycardia Syndrome, Chronic Orthostatic Intolerance
Objective Sleep Disturbances in Orthostatic Intolerance
We wish to study sleep architecture in patients with chronic orthostatic intolerance. We will test the null hypothesis that there is no difference in time during the various phases of sleep between patients and healthy control…
- Trial name
- NCT00581022
- Testing
- Polysomnography
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Parathyroid Hormone, Tenofovir Disoproxil Fumarate
The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With TDF
Nucleot(s)ide is an antiviral drug that can reduce the number of viruses, reduce the risk of HCC, regress hepatic fibrosis and reduce death from Hepatitis B viral infection.
- Conditions
- Parathyroid Hormone, Tenofovir Disoproxil Fumarate, Chronic Hepatitis B Virus, Vitamin D
- Trial name
- TDF (NCT05313477)
- Testing
- Ergocalciferol Capsules, Calcium carbonate
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Osteoporosis, Osteoarthritis
The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders
Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development…
- Trial name
- NCT02017067
- Testing
- hydraulic resistance circuit training
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Stroke, Acute Stroke
The Effects of Gait Rehabilitation After Stroke by Treadmill-based Robotics Versus Traditional Gait Training
This multicenter non-randomized controlled trial aims to investigate the effectiveness (an increase of the walking speed in the 10 Meter Walk Test - 10MWT) of the robotic treatment with exoskeleton or end-effector system compared…
- Conditions
- Stroke, Acute Stroke, Chronic Stroke
- Trial name
- TREAD_STROKE (NCT03688165)
- Testing
- Treadmill-based Robotic Gait Training, Traditional Over-ground Gait Training
- Where
- 4 sites in Italy
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Obesity and Overweight, Pre-diabetic
Targeted Precision Nutrition Strategy To Prevent Chronic Metabolic Diseases
Nutrition is very important to keep blood sugar levels balanced. If blood sugar levels are too high, it can lead to diseases such as cardiovascular disease and type 2 diabetes (T2DM).
- Conditions
- Obesity and Overweight, Pre-diabetic, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PRECINUT (NCT06923644)
- Testing
- Optimal Metabotype-specific diet, Sub-optimal diet
- Where
- 2 sites in Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Atopic Dermatitis, Atopic Dermatitis Eczema
Bioavailability and Tolerability of Fexofenadine Hydrochloride Topical Lotion 1%
The investigational lotion is envisaged as an short- and long term "Ease \& Prevent" monotherapy for adults and children with mild to moderate eczema.
- Conditions
- Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Rash, Rash
- Trial name
- ATOFEX-1 (NCT05461456)
- Testing
- Fexofenadine Hydrochloride Topical Lotion 1% (OP2101)
- Where
- Bangladesh
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OrchestratePharma GmbH
Asthma, COPD
An Evaluation of 9MW1911 Injection in Healthy Subjects
This study is a randomized, double-blind, dose-escalating phase I clinical study to evaluate the safety, tolerability and pharmacokinetics of 9MW1911 injection in healthy subjects.
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05803902
- Testing
- Experimental drug 9MW1911
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Alopecia Areata
Alefacept in Patients With Severe Scalp Alopecia Areata
The purpose of this study is to examine prospectively the safety and efficacy of alefacept in the treatment of subjects with severe alopecia areata of the scalp.
- Trial name
- NCT00167102
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Chronic Allergic Conjunctivitis
OTX-14-001: A Phase 2 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Chronic Allergic Conjunctivitis
The objective of the study was to evaluate the efficacy and safety of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of the signs and symptoms of…
- Trial name
- NCT02062905
- Testing
- Dexamethasone
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ocular Therapeutix, Inc.
Constipation
Evaluation of Acacia Gum on Microbiome and Bowel Function in Participants With Chronic Constipation
Proof of concept study to investigate the impact of a food supplement consisting of Acacia gum on changes of gut microbiota and production of short chain fatty acids.
- Trial name
- NCT04382456
- Testing
- acacia gum
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Alpinia Laudanum GmbH
Tendinopathy
The Effect of High Volume Injection With and Without Steroid in Chronic Achilles Tendinopathy
The aim of the study is to determine the effect of steroid in High Volume Injection (HVI) compared to HVI without steroid (volume effect) in functional outcomes and ultrasound tendon thickness and Color Doppler activity in…
- Trial name
- NCT02839577
- Testing
- High Volume injection without corticosteroid, High Volume injection with corticosteroid
- Where
- Denmark
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Chronic Kidney Disease, Hypertension
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
Age related stiffening and hardening of the arteries is often a slow process, but some conditions such as chronic kidney disease (CKD), seem to increase the rate at which the arteries stiffen even during childhood.
- Trial name
- ART-KIDS (NCT07768865)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College London
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