Clinical trials: copd or chronic obstructive
COPD, Healthy Subjects
Sublingual Tonometry to Assess Tissue Perfusion in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Sublingual positioning of a silicon capillary system is applied. After 15 min, while the individual is in resting position with closed mouth and normal tidal breathing through the nose is performed, the silicon capillary system…
- Trial name
- subton (NCT01169506)
- Testing
- sublingual silicon capillary
- Where
- Hungary
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Szeged University
Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD)
SAW Lung Microbiome Study in Smokers and Never-smokers
The trial aims to analyse changes in the microbiome of the lower airways after smoking cessation. Microbiome analyses (upper airway swabs, bronchoalveolar lavage, transbronchial brushing) are conducted in smokers before and 6…
- Conditions
- Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD), Healthy, Microbial Colonization
- Trial name
- NCT03562442
- Testing
- Smoking cessation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Research Center Borstel
Chronic Obstructive Pulmonary Disease (COPD), Traditional Chinese Medicine Syndrome
Multi-Omics Study of COPD Stages and Traditional Chinese Medicine Syndromes
This is a multicenter, prospective, observational cohort study of patients with chronic obstructive pulmonary disease (COPD), individuals with pre-COPD, and healthy participants.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Traditional Chinese Medicine Syndrome, Multi-omics
- Trial name
- NCT07873489
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma, COPD
Sputum and Plasma Levels of Nociceptin and Substance P in Patients With Asthma, COPD and Chronic Cough
The aims of this study are to investigate the association between sputum and plasma levels of nociceptin and substance P with cough severity and airway hyperreactivity in patients with asthma, COPD and chronic cough.
- Conditions
- Asthma, COPD, Cough
- Trial name
- NCT00173225
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Physiology
Physiopathology of Lower Cortical Activation in COPD Patients: Contribution of Cortical Neuromodulation
Patients with COPD have lower cortical activation and higher cortical inhibitory levels. The purpose of this study is to test the reversibility the lower cortical activation by counterbalancing the increased cortical inhibitory…
- Trial name
- NCT03368703
- Testing
- Anodal transcranial direct-current-stimulation
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- 5 Santé
COPD - Chronic Obstructive Pulmonary Disease, Forward Head Posture
Combined Posture Correction and Resistive Respiratory Muscles Training in COPD With FHP
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation, often exacerbated by postural abnormalities such as forward head posture (FHP).
- Trial name
- NCT07293429
- Testing
- Resistive inspiratory muscles training, Resistive expiratory muscles training:, Combined resistive inspiratory and expiratory muscles training
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Riphah International University
HIV, Cardiovascular Disease
Ugandan Non-Communicable Diseases and Aging Cohort
Longitudinal cohort study of older-aged people living with HIV infection in southwestern Uganda and age and gender-matched HIV uninfected controls with the primary aim of measuring the epidemiology of cardiovascular and pulmonary…
- Conditions
- HIV, Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Atherosclerosis
- Trial name
- UGANDAC (NCT02445079)
- Testing
- This is an observational study only
- Where
- Uganda
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
COPD
Clinical Pharmacology Study to Evaluate the Total Systemic Exposure and the Lung Availability of CHF 5993 in Healthy Volunteers
This clinical pharmacology study is performed to evaluate the total systemic exposure and the lung availability of CHF 5993 DPI and pMDI with and without valved holding chamber, in healthy volunteers.
- Trial name
- NCT02743013
- Testing
- CHF 5993 100/6/12,5 pMDI, CHF 5993 100/6/12,5 DPI Test 1, CHF 5993 100/6/12,5 DPI Test 2
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Gingivitis; Chronic
Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis
This pilot study aims to evaluate the effects of miswak use on the oral biological environment by comparing biochemical parameters obtained from saliva and dental plaque samples collected from individuals who use miswak and…
- Trial name
- NCT07689786
- Testing
- Miswak, Toothpaste
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
COPD
Whole Body Vibration in Chronic Obstructive Pulmonary Disease
The investigators designed the current study with the main objective of determining whether Whole Body Vibration Training (WBVT) alone improves muscular force and/or modifies the functional capacity parameters in severe Chronic…
- Trial name
- NCT01850173
- Testing
- A vertical vibration platform Fitybe
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Chronic Obstructive Pulmonary Disease
Utilizing Wearable Device to Observe the Clinical Response of COPD Patients Treated With Combined Bronchodilator and Home-based Pulmonary Rehabilitation Program
The effectiveness of combined bronchodilator and exercise training on improving exercise capacity has been reported in COPD. However, little is known about effect of respective treatment in a real-time monitoring.
- Trial name
- NCT03364829
- Testing
- Indacaterol/Glycopyrronium
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Asthma, Chronic Obstructive Pulmonary Disease COPD
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7594 Inhaled Formulation in Healthy Japanese Men
This is a randomized, single-blind, placebo-controlled, sequential-group study to assess the safety and tolerability as well as how the drug (AZD7594) affects the body (pharmacodynamics [PD]) and how the body affects the drug…
- Trial name
- NCT02645253
- Testing
- AZD7594 inhalation powder (200 μg), AZD7594 inhalation powder (400 μg), AZD7594 pressurized inhalation suspension (200 μg)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD
Effects of Breathing Exercises With and Without Inspiratory Muscle Training in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a major health issue that affects a large proportion of the population, especially those over 50 years old. It is characterized by breathlessness and reduced lung function.
- Trial name
- NCT06555445
- Testing
- BREATHING EXERCISE, BREATHING EXERCISE REGIMEN COUPLED WITH BREATHER DEVICE
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Chronic Obstructive Pulmonary Disease (COPD), Age Matched Healthy Volunteers (Non-smokers)
Effect of Symbicort on HAT and HDAC in Sputum Macrophages of COPD
The purpose of the study is to compare histone acetyltransferase (HAT) and histone deacetylase (HDAC) expressions and activities in induced sputum macrophages obtained from patients with moderate to severe COPD and age-matched…
- Trial name
- NCT00291408
- Testing
- Skin Prick Test, Impulse Oscillometry, Exhaled Nitric Oxide
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Reliability, Sensitivity and Validity of the 6 Minute Step Test in Chronic Obstructive Pulmonary Disease (COPD) Patients
Chronic Obstructive Pulmonary Disease (COPD) leads to a reduction in exercise capacity that affects the quality of life and increases mortality of these patients.
- Trial name
- NCT01298661
- Testing
- Six-minute Step Test
- Where
- Brazil
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
COPD, Small Airway Disease
The Prevalence of Small Airways Dysfunction In COPD Patients and The Impact on COPD Control
Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent disease. During recent years, increasing attention has been directed to the importance of the contribution of small airways in respiratory diseases.
- Trial name
- NCT04384133
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Chronic Pain, Back Pain Lower Back Chronic
Mind-body Treatments for Chronic Back Pain
Participants with chronic back pain will complete an online prescreen. They will then be randomized to one of two different studies: a placebo vs. waitlist study or a psychotherapy vs.
- Conditions
- Chronic Pain, Back Pain Lower Back Chronic, Back Pain, Low
- Trial name
- NCT03294148
- Testing
- Psychotherapy Treatment for Chronic Back Pain
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
COPD
HDAC Activity in Peripheral Skeletal Muscle in COPD
We wish to study the effect of Chronic Obstructive Pulmonary Disease on the activity of the nuclear transcription pathway in peripheral skeletal muscle to determine whether altered activity of this pathway may be responsible for…
- Trial name
- NCT00180752
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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