Clinical trials: copd or chronic obstructive
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Gingivitis; Chronic, Smoking
Synbiotic as an Adjunct to Mechanical Treatment of Gingivitis
The aim of this study is to evaluate the efficacy of oral administration of synbiotic tablets on the clinical parameters and the levels of selected inflammatory mediators in gingival crevicular fluid (GCF) in smokers and…
- Trial name
- NCT03455192
- Testing
- Synbiotic Supplement
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
COPD
Pharmacokinetic Interaction Study of Glycopyrrolate and Formoterol in Healthy Volunteers
This study will be carried out in healthy volunteers with the primary objective to evaluate the pharmacokinetic interaction between Glyco and Formoterol administered using a pressurised metered dose inhaler (pMDI).
- Trial name
- TRIPLE 1 (NCT01398111)
- Testing
- Glycopyrrolate + Formoterol, Glycopyrrolate, Formoterol
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD, Weaning Failure
VentFree: A Novel Abdominal Stimulator to Assist With Ventilator Weaning
Background: Over one million patients in the US are estimated to undergo mechanical ventilation every year, and approximately 300,000 of them fail attempts at weaning.
- Trial name
- NCT02224352
- Testing
- Functional neuromuscular electrical stimulation
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Edward Hines Jr. VA Hospital
Chronic Heart Failure, Chronic Obstructive Pulmonary Disorder
Nutritional and Functional Changes in Heart Failure and COPD
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01787682
- Testing
- BOOST High Protein
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
COPD
Phase 1/Phase 2a Study of AERO-007 Inhalation Solution, a Nebulized LABA/LAMA Combination for Maintenance Treatment of COPD
This is a phase 1/phase 2a, single dose, crossover study conducted in two parts. Part 1: Phase 1, open-label, 4-period crossover study in 8 healthy subjects to determine the optimal dose of AERO-001 and AERO-002, the active…
- Trial name
- NCT06841640
- Testing
- AERO-001, AERO-002, AERO-007
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
COPD
Biomarkers for Diagnosis and Treatment of COPD
COPD is an inflammatory disease characterized by enhanced chronic airway and lung inflammatory responses to noxious agents (e.g. smoke, pollutants) and progressive airflow limitation.
- Trial name
- BmiRCOPD (NCT02633280)
- Where
- 3 sites in Italy
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Chronic Obstr Lung Disease
Serum Interleukin 6 in Chronic Obstructive Pulmonary Disease
The aim of this study is to estimate level of IL 6 in COPD patients and its relation to COPD severity and acute exacerbation.
- Trial name
- NCT05214508
- Testing
- interleukin 6
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
COPD, Asthma Bronchiale
Pulmonary Deposition of Ultrasound Rock Salt Aerosol Inhalation Therapy
In the in vitro modeling phase, the investigators plan to use a realistic human upper respiratory tract model and an asymmetric ideal bronchial tree model.
- Conditions
- COPD, Asthma Bronchiale, Chronic Bronchitis
- Trial name
- NCT06891274
- Testing
- USN before SVN, SVN before USN
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Jingen Xia
COPD, Asthma
Assessment of Rheological Parameters of Human Sputum.
This is a proof of concept study. The aim of this study is to assess a device measuring rheological properties of human sputum of four populations : 10 patients with Broncho Chronic Obstructive Pulmonary Disease (COPD) 10…
- Conditions
- COPD, Asthma, Cystic Fibrosis
- Trial name
- RHEOMUCO (NCT02682290)
- Testing
- Expectoration and measurement of sputum rheological properties
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
OSA, Covid19
COPD Circuit Exercise
This study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in…
- Conditions
- OSA, Covid19, Residual Symptoms of COVID 19, COPD
- Trial name
- NCT05395390
- Testing
- Exercise (Resistance Training
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Pulmonary Disease, Chronic Obstructive, Microbiota
Analysis of the Microbiome in the Healthy Smokers and COPD Patients
This study is to build a microbiome cohort by collecting sputum and fecal samples every few months for three years from healthy smokers and chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04336423
- Testing
- Obtain samples from sputum and feces
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease
Relative Bioavailability Study With Abediterol Administered Via Three Different Inhalation Devices in Healthy Volunteers.
The study is intended to assess the relative bioavailability of 2 different abediterol nebulised formulations (test) and the dry powder formulation (reference).
- Trial name
- NCT04199598
- Testing
- Abediterol (2.4 μg), Abediterol (4.8 μg), Abediterol (2.5 μg)
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Lower Respiratory Tract Infection, Acute Bronchitis
Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
The purpose of this study is to validate the diagnostic accuracy of a novel host-response based diagnostic tool for differentiating between bacterial and viral etiologies in adult patients aged 18 years and older with clinical…
- Conditions
- Lower Respiratory Tract Infection, Acute Bronchitis, Pneumonia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OBSERVER (NCT03011515)
- Where
- Israel
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
COPD
Respiratory Muscle Stretching Effect on Functional and Electromyographic Parameters of Patients With and Without COPD
To evaluate the activation of accessory respiratory muscles and the effects of stretching these muscles in patients with COPD.
- Trial name
- NCT03417908
- Testing
- PNF
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Pampa
Chronic Obstructive Pulmonary Disease
Improving Cardiovascular Health in Patients With Chronic Obstructive Pulmonary Disease
Researchers have found a link between chronic obstructive pulmonary disease (COPD) and heart disease; however, a link is all they have found.
- Trial name
- NCT03819517
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Asthma, Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose in Healthy Volunteers, Repeat Doses in Asthmatic Patients and of Single Dose in COPD Patients of CHF6366
CHF6366 is a novel bifunctional compound displaying both muscarinic receptor antagonist and β2-adrenergic receptor agonist properties (MABA), with the potential to deliver optimal bronchodilation after inhalation dosing via two…
- Trial name
- NCT03378648
- Testing
- CHF6366, umeclidinium bromide and vilanterol trifenatate
- Where
- United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD(Chronic Obstructive Pulmonary Disease)
Evaluation of Reactive Oxygen Metabolites in the Value of COPD
This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD.
- Trial name
- NCT02297633
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Chronic Obstructive Pulmonary Disease
Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant
The study will assess the Pharmacokinetic (PK) and safety of BGF MDI [Budesonide/glycopyrronium/formoterol (BGF) metered dose inhaler (MDI)] formulated with 2 different propellants :Hydrofluoroolefin (HFO) and Hydrofluoroalkane…
- Trial name
- NCT05477108
- Testing
- Treatment A (BGF MDI HFO with oral activated charcoal), Treatment B (BGF MDI HFA with oral activated charcoal)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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