Clinical trials: copd or chronic obstructive
COPD, Smoking
COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function
Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated cells that mediate…
- Trial name
- NCT01974154
- Testing
- Cohort I, Cohort II
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Copd, Smoking
Clinical Features of Smoker Patients With Chronic Obstructive Pulmonary Disease
Smoking is the most important factor in the etiology of COPD. Some of the patients with COPD continue to smoke despite knowing this situation or they cannot quit even if they want.
- Trial name
- NCT04711629
- Testing
- Clinical Tests
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive
Smart Textile Sensor System for Health Monitoring
The present study will investigate a set of biomedical sensors with a wireless data communication system and evaluate the sensors' recording quality.
- Conditions
- Heart Disease Chronic, Pulmonary Disease, Chronic Obstructive, Blood Pressure, Heart Rhythm Disorder
- Trial name
- NCT05473702
- Testing
- Nanowear SimpleSense Wearable monitoring device
- Where
- 3 sites in United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Nanowear Inc.
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Assess Drug Absorption of Fixed Dose Combinations of Budesonide, Glycopyrronium, and Formoterol
The study will evaluate bioavailability, pharmacokinetics, safety, and tolerability of budesonide, glycopyrronium and formoterol (BGF) metered dose inhaler (MDI) formulated with 3 different propellants: Propellant 1 (Treatment A…
- Trial name
- NCT04600505
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic, Infection
Pulpectomy of Primary Molars With Rotary Instrumentation Versus Manual Instrumentation
One of the major concerns in pediatric dentistry is premature loss of necrotic primary teeth which may cause a deleterious effect on the growth of the facial skeletal complex.
- Trial name
- NCT03964766
- Testing
- Rotary instrumentation, Hand instrumentation
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Obstructive Pulmonary Disease
Combined Effects of ACBT and AUTOGENIC DRAINAGE in Patients With Chronic Obstructive Pulmonary Disease
A randomised controlled trial will be conducted with COPD patients as its target population. There will be 40 individuals for both the control group and the intervention group.
- Trial name
- NCT05922254
- Testing
- Active cycle of breathing technique, Autogenic drainage
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
COPD
Bronchial Obstruction in Dairy Farmers
Chronic Obstructive Pulmonary Disease (COPD) is a major public health problem and is expected to become the 3rd leading cause of death globally by 2020. The main risk factor is tobacco.
- Trial name
- BPCO Airbag (NCT03654469)
- Testing
- questionnaires and electronic mini-spirometry
- Where
- France
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Dementia, Diabetes Mellitus
Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population
This is a community-based cluster randomized control trial aimed to investigate the impact of lifestyle modification (diet, physical activity, alcohol drinking and smoking) on the development of dementia, diabetes, chronic kidney…
- Conditions
- Dementia, Diabetes Mellitus, Chronic Kidney Disease, Cardiovascular Diseases
- Trial name
- NCT02967406
- Testing
- 4 x 4 lifestyle modification
- Where
- Thailand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Severe Eosinophilic Asthma
Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma
Understanding how Interleukin-5 blockade modulates both immune and metabolic pathways may clarify the multidimensional impact of biologic therapy in severe eosinophilic asthma.
- Trial name
- NCT05063981
- Testing
- Mepolizumab
- Where
- 2 sites in Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Pulmonary Disease, Chronic Obstructive, Hypoxia
Hypoxia and Heart Rate Variability
The purpose of this study is to evaluate how variations in oxygen demands may change heart electrical activity in individuals with and without oxygen dependence.
- Trial name
- NCT05606406
- Testing
- Nocturnal Oxygen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
COPD, Healthy Older Adults
Acute Effects of Supramaximal High-Intensity Interval Training in People With COPD
High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging for most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations…
- Trial name
- COPD-HIIT-AC (NCT05874999)
- Testing
- Supramaximal High-Intensity Interval Training at 60% of MPO6, Moderate-Intensity Continuous Training, Supramaximal High-Intensity Interval Training at 80% of MPO6
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Umeå University
Healthy, Pulmonary Disease, Chronic Obstructive
Relative Bioavailability of of Olodaterol and Ketoconazole
This clinical trial is intended to investigate a possible effect of the p-gp inhibitor ketoconazole on the bioavailability of olodaterol
- Trial name
- NCT01153711
- Testing
- BI 1744, Ketoconazole
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Type 1 Diabetes, Asthma
EmoTIChealth: Promoting Adolescent Health Through a Serious Game.
The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong…
- Conditions
- Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy
- Trial name
- NCT07212530
- Testing
- EmoTIChealth
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Chronic Kidney Diseases, Obstructive Sleep Apnea
World Trade Center Kidney-Link
This study focuses on the prevalence and identification of kidney disease among participants of the WTC Health Program and the study team are planning to assess kidney disease in a multi-factorial manner.
- Trial name
- NCT03234530
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pulmonary Disease, Chronic Obstructive
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.
- Trial name
- NCT00687700
- Testing
- GSK961081, Propranolol
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
COPD
Comparative Effects of Breather Device and Incentive Spirometer in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized and defined by limitation of expiratory airflow. This can result from several types of anatomical lesions, including loss of lung elastic recoil and fibrosis and…
- Trial name
- NCT07435532
- Testing
- breather device, incentive spirometer
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole
The current study will help to increase our understanding of the pharmacokinetics (PK) of danirixin. The primary objective of the study is to estimate the relative bioavailability of danirixin Hydrobromide (HBr) tablet, when…
- Trial name
- NCT02453022
- Testing
- Danirixin HBr 50 mg IR Tablet, Danirixin FB 50 mg IR Tablet, Prilosec (omeprazole) 40mg Delayed-Release capsule
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Postural; Defect
An Investigation of the Cervical Region Biomechanics in Patients With Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate cervical region biomechanics, muscle performance and respiratory muscle strength in patients with Chronic Obstructive Pulmonary Disease (COPD) compared to healthy subjects.
- Conditions
- Chronic Obstructive Pulmonary Disease, Postural; Defect, Cervical Pain, Cough
- Trial name
- NCT06246370
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Obstructive Pulmonary Disease
Effects of Diaphragm and Abdominal Muscle Training on PFT and Dyspnea Among COPD Obstructive Pulmonary Disease Patients.
It will be a randomized control trial at Services Hospital Lahore through convenience sampling technique which will be allocated through simple random sampling through sealed opaque enveloped in to Group A and Group B .
- Trial name
- NCT05587829
- Testing
- • Diaphragmatic breathing technique, basic breathing technique
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Riphah International University
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