Clinical trials: copd or chronic obstructive
Chronic Obstructive Pulmonary Disease
Proteasis Evaluation in COPD
The aim of this study was to evaluate kallikreins and its substrate, CCN, in COPD patients. Kallikreins are a subgroup of serine proteases, enzymes which are able to cleave peptide bonds in proteins.
- Trial name
- Pro-BPCO (NCT01713335)
- Where
- France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Obstructive Pulmonary Disease
A Study to Assess the Total Systemic Exposure Bioequivalence of of Budesonide, Glycopyrronium, and Formoterol Delivered by BGF MDI With Next-Generation Propellant Compared With BGF MDI With HFA Propellant
The study will evaluate bioequivalence, pharmacokinetics, safety, and tolerability of Budesonide, Glycopyrronium and Formoterol (BGF) metered dose inhaler (MDI) formulated with hydrofluoroolefin (HFO) [Test] and hydrofluoroalkane…
- Trial name
- NCT05569421
- Testing
- Treatment A: BGF MDI HFO, Treatment B: BGF MDI HFA
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease (COPD)
Lung Imaging of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
This is a prospective interventional study examining the use of Annexin - a radioactive tracer, in assessing lung damage in healthy volunteers, healthy volunteers actively smoking, and patients with moderate and severe chronic…
- Trial name
- NCT02978144
- Testing
- AxV-128/Tc
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Columbia University
Healthy
PH-797804 LPS Study in Healthy Volunteers
The study was performed to assess the effect of PH-797804 on neutrophils (white cells) in the sputum after a challenge with an endotoxin (inhaled LPS).
- Trial name
- NCT02084485
- Testing
- PH-797804
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
COPD, Obstructive Ventilation Disorder
Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the…
- Conditions
- COPD, Obstructive Ventilation Disorder, Pulmonary Emphysema
- Trial name
- NCT02827721
- Testing
- impulse oscillometry, multiple breath washout test, body plethysmography
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
COPD(Chronic Obstructive Pulmonary Disease)
Evaluation of Reactive Oxygen Metabolites in the Value of COPD
This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD.
- Trial name
- NCT02297633
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Hypertension (HTN), Diarrhea
Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat.
Background: Age specific mortality rate (ASMR) of 16-60 years is very high in Indian tribal areas due to communicable and non-communicable diseases.
- Conditions
- Hypertension (HTN), Diarrhea, Pneumonia, Malaria Fever
- Trial name
- MCPEPAG (NCT07436104)
- Testing
- Trained village health workers (VHWs) , provided treatment of HTN, diarrhoea, malaria, pneumonia, asthma and COPD by Amlodipine, ORS, Norfloxacin, Chloroquine, Azithromycin, salbutamol rotacaps, Appropriate referral
- Where
- India
- Volunteers
- 72,564 people, healthy volunteers welcome
- Sponsor
- MAHAN Trust
Evaluate the Efficacy and Safety of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
Phase III Study to Evaluate the Efficacy and Safety of HOB-048 CR Tab. in Comparison With HOB-048 Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
A randomized, double-blind, multicenter, active-controlled phase III study to evaluate the efficacy and safety of Levotuss CR tab. in comparison with Levotuss syrup in patients with cough due to acute or chronic bronchitis
- Trial name
- NCT03489837
- Testing
- Levotuss
- Where
- South Korea
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharm
Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease
ENOSE in Pulmonary Tuberculosis in Yogyakarta
Electronic noses detecting patterns of volatile molecules have recently been introduced for different diagnostic purposes. The diagnostic accuracy of a prototype e-nose device (Bruins et al (2013) in Bangladesh showed sensitivity…
- Conditions
- Pulmonary Tuberculosis Suspected, Other Specified Chronic Obstructive Pulmonary Disease, Pulmonary Tuberculosis TB (+) Histology, (-) Bacteriology
- Trial name
- YOGYATBNOSE (NCT02219945)
- Testing
- 5 min exhaled breath sampling with soft nose clamp
- Where
- Indonesia
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Tjip van der Werf
COPD (Chronic Obstructive Pulmonary Disease)
Effect of an App-based Intervention on Air Pollution in COPD Patients
This study will test whether a combination of health education, a mobile app, and a smart band can help people with chronic obstructive pulmonary disease (COPD) improve their quality of life and reduce flare-ups.
- Trial name
- NCT07074093
- Testing
- app+smartband+education
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Bronchomalacia, Asthma
Mapping Sound Propagation Through the Human Lung for Better Diagnosis
This study investigates the propagation of sound from a source in the chest to the chest wall. The methodology of the study will be to place a sound source at a known location in the chest and measure the acoustic response on the…
- Conditions
- Bronchomalacia, Asthma, Lung Neoplasms, Lung Diseases, Interstitial
- Trial name
- NCT03043898
- Testing
- Lung sound transmission measurement, Lung sound recording
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maximilian Nussbaumer
Asthma, Copd
A Study to Obtain Normal Values of Inflammatory Variables From Healthy Subjects
Smoking induces an inflammatory reaction in the airways which can ultimately result in persistent damage and the development of a Chronic Obstructive Pulmonary Disease (COPD). However, not all subjects who smoke end up with COPD.
- Trial name
- NORM (NCT00848406)
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease
The Chronic Obstructive Pulmonary Disease Fish Oil Pilot Trial
Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the United States. Unlike the other leading causes of death, no medical therapies currently available improve the course of disease or…
- Trial name
- COD-Fish (NCT00835289)
- Testing
- n-3 polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Urinary Incontinence
Pelvic Floor Exercises Versus Pilates on Urinary Incontinance in Chronic Obstructive Pulmonary Disease
The aim of the study is To compare between the effect of both pelvic floor and Pilates exercises on urinary incontinences in COPD patients.
- Trial name
- NCT06337240
- Testing
- Pelvic floor on COPD patients, Pilates exercises on COPD patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Obstructive Pulmonary Disease, Healthy Volunteers
Understanding Balance Impairment in COPD
This study is an observational study investigating the mechanisms of balance problems in people with COPD and how COPD impacts them living their daily lives.
- Trial name
- NCT05984498
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Teesside University
Pulmonary Disease, Chronic Obstructive
Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK2269557 Administered Via the ELLIPTA Dry Powder Inhaler to Healthy Subjects
GSK2269557 is a potent and highly selective inhaled Phosphoinositide 3-Kinase delta inhibitor being developed as an anti-inflammatory and anti-infective agent for the treatment of inflammatory airway diseases.
- Trial name
- NCT02691325
- Testing
- GSK2269557 ELLIPTA DPI, Activated charcoal
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hemiparesis, Ischemic Stroke
Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
The investigators will study motor recovery after robot-assisted therapy after stroke. A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and…
- Conditions
- Hemiparesis, Ischemic Stroke, Chronic
- Trial name
- NCT00878085
- Testing
- Robot Therapy Device, Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Chronic Obstructive Pulmonary Disease
Influence of Electronic Cigarettes in the Evaluation of the Inflammatory Response in Patients With a Diagnosis of COPD
This study evaluates the local and systemic inflammatory response in the airway in COPD patients who consume electronic cigarettes compared with conventional cigarette smokers.
- Trial name
- NCT02892396
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fundacio Catalana de Pneumologia
Chronic Obstructive Pulmonary Disease
Involvement of Nervous System in Muscle Weakness in COPD Patients
The purpose of this study is to determine whether nervous system alterations and motor drive failure can contribute to muscle weakness in COPD during voluntary movement.
- Trial name
- DesCoM-1 (NCT01679782)
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- 5 Santé
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