Clinical trials: copd or chronic obstructive
COPD (Chronic Obstructive Pulmonary Disease)
Phase 1 PK Study of AERO-007, an Inhaled LABA+LAMA Combination for Nebulization Delivery in COPD Patients
This is a phase 1, single-dose, 2-period crossover study in healthy volunteers to compare the systemic pharmacokinetic (PK) profile of inhaled AERO-002 versus inhaled active comparator product.
- Trial name
- NCT07802730
- Testing
- AERO-002 (60 mcg), Glycopyrrolate (18 mcg)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AeroRx Therapeutics Inc.
Pulmonary Disease, Chronic Obstructive
Physical Exercise and Responses Measured by HIF-1 in COPD
Despite being considered a potentially preventable disease, COPD is classified as one of the respiratory problems with the highest prevalence and socioeconomic impact.
- Trial name
- ECOPDHIF-1 (NCT04955977)
- Testing
- Physical exercise program, Health education in COPD
- Where
- Colombia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Chronic Obstructive Pulmonary Disease (COPD), Decompensated COPD With (Acute) Exacerbation
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease Patients - Impact of Non Invasive Ventilation
In the investigators' knowledge there are no data about the impact of non invasive mechanical ventilation on the breathing-swallowing interaction.
- Trial name
- NCT01518075
- Testing
- Spontaneous Breathing, Non Invasive Mechanical Ventilation
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
COPD, Chronic Bronchitis
Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis
The purpose of this study is to evaluate the effect of Losartan on cigarette smoke-induced lung injury in smokers and ex-smokers with and without chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT02416102
- Testing
- Losartan 50 mg, Losartan 100 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Miami
Chronic Obstructive Pulmonary Disease
Association Between Cardiopulmonary Function and Plantar Pressure in Patients With Chronic Obstructive Pulmonary Disease
It aims to understand the differences in everyday mobility and activity capabilities among patients with varying disease progression and severity, to serve as reference indicators for evaluating the effectiveness of pulmonary…
- Trial name
- NCT06579872
- Testing
- plantar pressure
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Chronic Obstructive Pulmonary Disease
Determinants of Balance in Patients With Chronic Obstructive Pulmonary Disease
The primary aim of our study is to examine the relationship between balance and respiratory function, respiratory and peripheral muscle strength, functional capacity, and cognitive function in patients with Chronic Obstructive…
- Trial name
- NCT05771506
- Testing
- Balance Assessment, Pulmonary function test, Respiratory muscle strength test
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biruni University
Chronic Obstructive Pulmonary Disease
The Effects on Sleep qualıty and fatıgue Level of Foot Bath
Aims and objectives: To determine the effect of foot bath on sleep quality and fatigue level in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05668247
- Testing
- FOOT BATH
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sevil Şahin
COPD
Study to Investigate the Pharmacokinetics of CHF 6001 DPI Administered Via Nexthaler® Device or the Capsule for Oral Inhalation Via Aerolizer® Device
The purpose of this study is to compare the systemic availability to CHF 6001 after a single dose of CHF 6001 administered using the multi-dose NEXThaler® device or the single-dose capsule inhaler Aerolizer®.
- Trial name
- NCT02119247
- Testing
- CHF 6001 dry powder for inhalation via NEXThaler®, CHF 6001 DPI capsules for inhalation via Aerolizer
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease
Genetic Polymorphism in Matrix Metalloproteinase 9 in Chronic Obstructive Pulmonary Disease in Sohag University Hospital.
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex disease with multiple clinical presentations or phenotypes and remains a highly prevalent condition, causing significant morbidity and mortality…
- Trial name
- NCT06503315
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sohag University
Chronic Obstructive Pulmonary Disease, Cardiovascular Disease
COPD and Cardiovascular Risk in the Population
The prevalence of chronic obstructive pulmonary disease (COPD) in patients with cardiovascular disease (CVD) is unknown, and whether or not COPD is adequately diagnosed and treated in these patients has not been investigated…
- Trial name
- CORSAIB (NCT00787748)
- Where
- Spain
- Volunteers
- 623 people, healthy volunteers welcome
- Sponsor
- Cimera
Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA)
Brain During Effort : Effects of Hypoxia With Respiratory Patients
Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow (CBF), the modification of one or the other can affect the neuronal O2 availability.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Sleep Apnea Obstructive (OSA), Healthy Volunteers
- Trial name
- NEUROX (NCT02854280)
- Testing
- Pedalling exercise on a cycle ergometer, Isolated contractions of the quadriceps
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Asthma, Chronic Obstructive Pulmonary Disease (COPD), or Chronic Lung Disease (E.G., Chronic Bronchitis and Restrictive Lung Diseases Such as Asbestosis), The Effect of Yoga, Paranayama Yoga Practice on Respiratory Diseases
EFFECT OF PRANAYAMA YOGA ON COPD
The aim of the study In this study, pranayama yoga practices are the sub-dimensions of respiratory parameters, symptom and disease affection level, psychosocial adjustment and psychosocial adjustment in individuals with COPD.
- Trial name
- COPD (NCT06022627)
- Testing
- Pranayama Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Chronic Obstructive Pulmonary Disease
Thora-3DI™ for Evaluation of Severity of Chronic Obstructive Pulmonary Disease (COPD)
To demonstrate differences in tidal breathing patterns measured by SLP(Structured Light Plethysmography) between healthy subjects and COPD (chronic obstructive pulmonary disease).
- Trial name
- SLPCOPD (NCT03492359)
- Testing
- Thora-3Di, Body Plethysmography, Spirometry
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Chronic Obstructive Pulmonary Disease, Asthma
Lung Deposition of TRIMBOW® pMDI in Healthy Volunteers, Asthmatic and COPD Patients
The purpose of this study is to investigate the lung deposition and distribution pattern of TRIMBOW using a Gamma-scintigraphic technique after inhalation of a single dose of 99mTc radiolabelled TRIMBOW administered via pMDI in…
- Trial name
- STORM (NCT03795350)
- Testing
- Beclometasone dipropionate Formoterol Fumarate Glycopyrronium Bromide
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma, Cough
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal…
- Conditions
- Asthma, Cough, Cough Variant Asthma
- Trial name
- NCT03105843
- Testing
- Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dr. Diane Lougheed
Mountain Sickness, Chronic
Chronic Mountain Sickness, Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD) or emphysema, represent major medical and socio-economical problems and one of the leading cause of morbidity and mortality in the…
- Trial name
- CMS (NCT01182792)
- Testing
- Vitamin C and E
- Where
- 2 sites in Bolivia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Pulmonary Disease, Chronic Obstructive
Safety, Tolerability and Pharmacokinetics of GSK3923868 Inhalation Powder in Healthy Participants and Stable Asthmatics
This is a first time in human (FTIH) study designed to evaluate the safety, tolerability and pharmacokinetic (PK) profile of single and repeat doses of GSK3923868 inhalation powder in both healthy participants and asthmatics.
- Trial name
- NCT04585009
- Testing
- GSK3923868, Monodose RS01
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease (COPD), Environmental Exposure
Detection and Characterization of COPD in Dairy Farmers
A pilot study from the investigators group suggests that the prevalence of chronic obstructive pulmonary disease (COPD) among dairy farmers is higher than in the general population.
- Trial name
- BALISTIC (NCT02540408)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Chronic Obstructive Pulmonary Disease Moderate, Obesity
Aerosol Therapy in Obese COPD Patients.
This study has the objective to clarify the factors that directly influence the effectiveness of inhaled drug deposition in obese patients with chronic obstructive pulmonary disease (COPD) and suggest the use of High Flow Nasal…
- Trial name
- NCT03031093
- Testing
- inhalation protocol, High Flow Nasal Cannula
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Obesity, COPD, OHS
Hypoxia in Flight Simulation in Obese Patients
The purpose of this pilot study is to determine whether obese adults,obese (BMI>30 kg/m2) with obesity hypoventilation or obese COPD-patients do undergo oxygen desaturation under flight simulation and if the hypoxic altitude…
- Trial name
- NCT02636465
- Testing
- flight simulationin obese healthy adults or obese patients with or without COPD, OHS
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
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