Clinical trials: copd or chronic obstructive
Chronic Obstructive Pulmonary Disease
Modulation of Dyspnea Perception During Exercise in COPD Patients Using Attentional Distraction
Chronic obstructive pulmonary disease (COPD) is a major health problem whose prevalence is increasing rapidly. The gradual decrease in exercise tolerance is one of the usual consequences of COPD that affects the functional…
- Trial name
- DVD (NCT01902927)
- Testing
- Attentional distraction using IAPS protocol (standardized images)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease (COPD)
Translating The GOLD COPD Guidelines Into Primary Care Practice
This project will evaluate the translation of the Gold (the Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease) COPD guidelines into primary care practice.
- Trial name
- LungAge (NCT01237561)
- Testing
- provider support tools plus spirometer
- Where
- United States
- Volunteers
- 3,593 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
COPD, Bronchiectasis
Metabolomic Analysis of Exhaled Breath Condensates in Patients With COPD and Bronchiectasis
Metabolomics is a large-scale approach to monitoring the compounds involved in cellular processes. It may reflect changes in biological function.
- Trial name
- NCT01410422
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Pulmonary Disease, COPD
Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease. Ratio-Study. (BY217/M2-112)
The purpose of this study is to investigate the effect of 500mcg roflumilast vs placebo on exacerbation rate and pulmonary function as well as quality of life in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00430729
- Testing
- Roflumilast
- Where
- 14 sites in Australia, Austria and 12 more
- Volunteers
- 1,100 people
- Sponsor
- AstraZeneca
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Chronic Obstructive Pulmonary Disease
Developing Personalised Relative Physical Activity Thresholds in COPD.
The aim of this observational study is to translate the principle of individualised exercise prescription into the evaluation of daily absolute and relative intensity physical activity.
- Trial name
- IMPACT (NCT06330623)
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Leicester
Foot Ulcer, Diabetic
Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers
The goal of this clinical trial is to determine the safety of DERMASEAL for the treatment of non-healing, neuropathic diabetic foot ulcers. The main outcome measure is safety.
- Trial name
- NCT05586542
- Testing
- DERMASEAL, Plasma Film, Standard of Care
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Vitruvian Medical Devices, Inc.
Chronic Graft-Versus-Host Disease
A Prospective Observational Study for Evaluating CGVHD
Prospective, observational, multicentre, spontaneous, non-interventional study This study will evaluate all consecutive patients who develop chronic graft-versus-host disease, reported by the Italian GITMO centers according to a…
- Trial name
- GITMO-GVCrOSy (NCT02991846)
- Where
- 27 sites in Italy
- Volunteers
- 248 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
COPD, Heart Failure, Congestive
Clinical Assessment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and/or Chronic Heart Failure (CHF)
Cigarette smoking, the major risk factor for COPD, causes not only airway and lung inflammation, but also systemic effects. These systemic effects of smoking could substantially contribute to the development of chronic diseases…
- Trial name
- NCT01114386
- Testing
- Lung function testing, echocardiography, blood sampling
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Interoceptive Awareness
Interoception and Symptom Perception in Acute COPD Exacerbation
Interoception refers to the process of perceiving and interpreting internal physiological signals and plays a central role in symptom perception.
- Trial name
- NCT07719231
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Obstructive Pulmonary Disease Moderate
Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days.
- Trial name
- COPD (NCT03020862)
- Testing
- Dietary beetroot juice
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Alpha 1-Antitrypsin Deficiency
Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency
The ADVANCE study is being conducted by Adverum Biotechnologies, Inc. as an open-label, multicenter, dose-escalation study in order to assess the safety and protein expression of ADVM-043 following a single intravenous or…
- Trial name
- ADVANCE (NCT02168686)
- Testing
- ADVM-043
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Adverum Biotechnologies, Inc.
COPD, Emphysema
Bronchitis and Emphysema Advice and Training to Reduce Hospitalization
EXECUTIVE SUMMARY: Purpose: To evaluate the efficacy and cost-effectiveness of a novel intervention incorporating self-management education, an action plan, and case-management to decrease the risk of hospitalizations due to…
- Trial name
- BREATH (NCT00395083)
- Testing
- COPD Self-management Education
- Where
- 22 sites in United States
- Volunteers
- 426 people
- Sponsor
- US Department of Veterans Affairs
Non-Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC)
Bone-marrow-derived progenitor cells (EPCS) play an important role in neovascularization and tumor growth. In lung cancer, angiogenesis is an important event in mechanisms of tumor proliferation and metastasis.
- Trial name
- CBNPC:PCE (NCT00826683)
- Testing
- Enumeration of endothelial cell progenitor in peripheral blood by flow cytometry, Endothelial cell progenitor characterization by primary cell cultures
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Chronic Obstructive Pulmonary Disease
Improving Patient-Centered Care Delivery Among Patients With Chronic Obstructive Pulmonary Disease
This study involves development and testing of a patient and family-centered transitional care program for patients who are hospitalized with Chronic Obstructive Pulmonary Disease (COPD) exacerbations.
- Trial name
- BREATHE (NCT02036294)
- Testing
- BREATHE program, Usual Care
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Aclidinium Bromide at Two Dose Levels Versus Placebo Administered in Chronic Obstructive Pulmonary Disease (COPD) Patients
The main purpose of this study is to assess the long term bronchodilator efficacy, safety and tolerability of inhaled aclidinium bromide at two dose levels compared to placebo in COPD patients and the benefits of the product in…
- Trial name
- NCT01001494
- Testing
- Aclidinium bromide 200 μg bid, Aclidinium bromide 400 μg bid
- Where
- 106 sites in Czechia, France and 9 more
- Volunteers
- 828 people
- Sponsor
- AstraZeneca
COPD
Adipose Derived Stem Cells Transplantation for Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the name for a collection of lung diseases including chronic bronchitis, emphysema and chronic obstructive airways disease.
- Trial name
- NCT02645305
- Testing
- Adipose derived stem cells
- Where
- 3 sites in Vietnam
- Volunteers
- 20 people
- Sponsor
- University of Science Ho Chi Minh City
Cancer, Cancer Cachexia
A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
The purpose of this study is to evaluate the safety and effectiveness of fish oil supplements in maintaining weight in people with disease-related weight loss and/or cachexia.
- Conditions
- Cancer, Cancer Cachexia, Chronic Obstructive Pulmonary Disease, Chronic Heart Failure
- Trial name
- NCT00094562
- Testing
- Fish oil supplement
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Chronic Obstructive Pulmonary Disease, Alpha1-antitrypsin Deficiency
ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study
The purpose of this study is to evaluate the efficacy of ARALAST NP A1PI augmentation therapy 120 milligrams per kilogram (mg/kg) body weight (BW)/week compared with an external placebo comparator on the loss of emphysematous…
- Trial name
- NCT04440488
- Testing
- ARALAST NP
- Sponsor
- Shire
COPD, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05435183
- Testing
- Non-invasive high-frequency oscillatory ventilation, Noninvasive Bilevel Positive Pressure Ventilation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
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