Clinical trials: fNIRS
Major Depressive Disorder, Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
- Trial name
- NCT06897670
- Testing
- Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Healthy Aging
Effects of Adding Force Control to a VR Game on Brain Activation
One of the major contributor for the lower quality of living in the aged population, is the reduction in hand function. To mitigate this, several virtual-reality based hand rehabilitation/training systems have been developed.
- Trial name
- NCT06412887
- Testing
- Virtual reality headset
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Acute Pain, Pediatric ALL
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR).
- Conditions
- Acute Pain, Pediatric ALL, Procedural Pain, Burns
- Trial name
- NCT06303687
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
Multiple Sclerosis
Comparing the Acute Effects of Different Exercise Approaches in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is the second most common neurological disorder in young adults after trauma. Treatments developed today can slow progression and reduce symptoms.
- Trial name
- NCT06721416
- Testing
- Traditional Aerobic Exercise, VR Based Aerobic Exercise, Conventional Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Acibadem University
Acute Pain, Experimental Pain in Healthy Human Participants
Healthy Children and Virtual Reality Mediation of Simulated Pain
The objective of this study is to develop central nervous system (CNS) biomarkers of pain experienced during medical procedures and pain relief induced by Virtual Reality Pain Alleviation Therapy (VR-PAT).
- Conditions
- Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
- Trial name
- NCT06854991
- Testing
- Active VR-PAT, Passive VR-PAT, iPad
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Depressive Disorder, Major
Probing Prefrontal Cortex Hemodynamic Alterations for Major Depression Disorder
Major depression disorder (MDD) has high estimated lifetime prevalence rates of 16.6%. Currently, the diagnosis for the MDD mainly depends on patients' reports of symptoms, observed behaviors and disease course.
- Trial name
- MDD (NCT03595020)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Tinnitus
Application of Machine Learning Based on fNIRS in Predicting Acupuncture's Efficacy in Treating Tinnitus
This trial aims to use machine learning to analyze fNIRS imaging data of specific brain regions of tinnitus patients, thereby constructing a predictive model of the clinical efficacy of acupuncture for SNT.
- Trial name
- NCT06364670
- Testing
- acupuncture
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Healthy
Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation
In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects…
- Trial name
- NCT04019028
- Testing
- low frequency rTMS + Navigation System, only low frequency rTMS
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stroke, Healthy
fNIRS Study of Effort-dependent Brain Activations During Pointing Movements of the Upper Limb in Post-stroke Patients and Healthy Subjects
Background: Following a stroke, as part of neurorehabilitation, the intensity of effort is important to promote neural changes and stimulate motor recovery.
- Trial name
- BIROBONIRS (NCT06116006)
- Testing
- Upper limb pointing movements in 3 experimental conditions
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Clinique Les Trois Soleils
Healthy
Study of Cerebral Activation by fNIRS During Gait With Different Rhythmic Auditory Stimulations in Healthy Subjects
The purpose of this study is to investigate the cerebral activation in healthy subjects in 4 conditions of gait : Gait at preferred cadence without auditory stimulation (Gait1) Gait with low tempo rhythmic auditory stimulation by…
- Trial name
- MoveNIRS (NCT05789121)
- Testing
- walking 25 m in 4 different conditions
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Healthy Adult
Exploring the Modulatory Role of Brain State on the Prefrontal Response to Excitatory Stimulation
Therapeutic repetitive transcranial magnetic stimulation (rTMS) for depression is well-supported, with multiple protocols approved by the United States Food and Drug Administration and global efforts aimed at boosting its…
- Trial name
- NCT06750614
- Testing
- intermittent theta-burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Electroencephalogram (EEG)
Analysis of Electroencephalogram (EEG) Changes in Subacute Stroke Patients
This study aims to examine how electroencephalogram (EEG) measures change over time in patients with stroke and to compare EEG measures according to the location of brain injury.
- Trial name
- NCT07882082
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Bundang CHA Hospital
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 3 of 7)
NOTE: This is the third of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882542
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Bern
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 4 of 7)
NOTE: This is the fourth of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02919228
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Shoulder Pain, Chronic Pain
Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling
The benefit experienced by some patients when treated with dry needling,1 combined with the field-expedient nature of this intervention, make dry needling uniquely suited for the military healthcare environment.
- Conditions
- Shoulder Pain, Chronic Pain, Musculoskeletal Injury
- Trial name
- NCT04170803
- Testing
- Dry Needling
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Army-Baylor University Doctoral Program in Physical Therapy
Stress
The SENSE Study: Surgical ENvironment Stress Evaluation
Surgical procedures such as total hip and knee arthroplasty require a complex set of physical and cognitive skills, expert execution, and inevitably place a high stress load on the surgeon.
- Trial name
- SENSE (NCT07506330)
- Testing
- total joint arthroplasty
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Major Depressive Disorder Remission, Major Depressive Disorder
Vulnerability Markers for Depression
The current study is a pilot for the GRF project entitled "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS".
- Conditions
- Major Depressive Disorder Remission, Major Depressive Disorder, Healthy
- Trial name
- NCT06402422
- Testing
- Theta-burst stimulation
- Where
- Hong Kong
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Depression
Activation on LDPC Cortex With Different Acupoints: An fNIRS Study
This is a randomized, open-labelled study to study the effect of the different acupoints combination under TCM treatment principles by fNIRS.
- Trial name
- NCT02711527
- Testing
- Acupunture group A, Acupunture group B
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Athletes, Sports Performance
Neuro-Psychophysiological Characteristics of Athletes With Varying Levels of Experience
This study aims to investigate the effects of an 8-week volleyball-specific stroboscopic training program on neuro-psychophysiological outcomes in female volleyball players with different levels of competitive experience.
- Conditions
- Athletes, Sports Performance, Visual-Motor Processing, Neuro-Psychophysiological Responses in Athletes
- Trial name
- NEPSY-SPORT (NCT07392385)
- Testing
- Stroboscopic Volleyball Training, Conventional Volleyball Training (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bozok University