Clinical trials: in Vitro Fertilisation
in Vitro Fertilization, Poor Responder
Dopamine D-2 Antagonist Use in Poor Responders in IVF: a Randomized Controlled Trial
Metoclopramide is a dopamine D2 receptor antagonist with antiemetic and gastrokinetic properties which has been approved for use in pregnant women.
- Trial name
- NCT02262923
- Testing
- metoclopramide
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Women Who Suffer From Hydrosalpinx That is Causing Infertility and Whom Want a Safer Way of Treamtent
Use of Essure® Micro-inserts in Women With Hydrosalpinx Prior to In Vitro Fertilization: A Prospective, Multicenter, International Feasibility Study
The purpose of this study is to gather safety data related to the use of Essure® micro-inserts in women with hydrosalpinx prior to in vitro fertilization and during pregnancy and to collect data with regard to implantation rates…
- Trial name
- NCT01221974
- Testing
- Essure Micro Insert
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Reproductive Science Center
Infertility, in Vitro Fertilization
Ultrasound Guided Embryo Transfer: Abdominal Versus Transvaginal, a RCT
Ultrasound (US) guided embryo transfer (ET) appears to improve pregnancy outcomes in IVF-ET. Most reports are done using a transabdominal (TAS) approach, in contrast to a transvaginal ultrasound (TVS) which does not require a…
- Trial name
- NCT00682071
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Infertility, Recurrent Miscarriage
Effect of Influenza Vaccination on Donor Egg Recipient Outcomes
In this study the investigators propose a randomized controlled trial to evaluate the effect of influenza vaccination on clinical pregnancy rates among women undergoing in vitro fertilization as donor egg recipients.
- Trial name
- DE-FluVac (NCT02946177)
- Testing
- Influenza Vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, IVF
Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen
The goal of this clinical trial is to evaluate the importance of differential O2 tension to the developing embryos. As a secondary aim, we investigate the levels of reactive oxygen species (ROS) in spent media from the developing…
- Conditions
- Infertility, IVF, Embryo
- Trial name
- NCT05737381
- Testing
- Differential oxygen tension
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
in Vitro Fertilization
The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome
Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by comet assay in unexplained infertile patients undergoing in vitro fertilization (IVF) treatment.
- Trial name
- NCT03345030
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Anxiety, in Vitro Fertilization
Impact of Virtual Reality Before Oocytes Retrieval on Anxiety and Pregnancy Rate
The primary objective of this study is to evaluate the impact of a session of virtual reality (VR) with the objective of lowering the anxiety level on the clinical pregnancy rate following an In-vitro fertilisation (IVF)…
- Conditions
- Anxiety, in Vitro Fertilization, Virtual Reality
- Trial name
- NCT03064061
- Testing
- Virtual reality
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Each Patient is Both Case and Control, 1 Embryo Will be Biopsied and 1 Embryo is Not
Evaluation of the Impact of Embryo Biopsy on the Reproductive Potential of Embryos Undergoing In Vitro Fertilization (IVF)
To assess the impact of embryo biopsy on the reproductive potential of human embryos.
- Trial name
- NCT01219504
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Subfertility
Effect of a Higher Than Maximum 450IU Gonadotropin Dose in an In-vitro Fertilization Cycle
This goal of this study is to evaluate the outcomes from in vitro fertilization cycles where a 450 IU daily dose of gonadotropins is administered compared to those where a 600 IU daily dose is administered for women who are at…
- Trial name
- NCT00971152
- Testing
- menotropins for injection, urofollitropin for injection
- Where
- Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Clinique Ovo
IVF, Pregnancy
Evaluation of the Relationship Between Oxidative Stress and Human Reproduction
The aim of the study is to investigate the role of oxidative stress in female infertility and the relationship between the stress as it is illustrated by questionnaires, serum markers, follicular fluid markers, and ovarian…
- Conditions
- IVF, Pregnancy, Oxidative Stress, Fertility Disorders
- Trial name
- OxidStressHR (NCT05575739)
- Testing
- Measurement of oxidative stress levels (Malondialdehide, glutathione disulphate, total antioxidant capacity, superoxide dismutase and carbonylated proteins )
- Where
- Romania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Calla IVF Center
Infertility, Female
Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)
This a trial designed to test whether granulocyte colony stimulating factor (G-CSF, Neupogen) can increase the rate of embryo implantation following IVF and embryo transfer.
- Trial name
- NCT01202656
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, In Vitro Fertilization
Video-Supported Medication Education for Women Undergoing In Vitro Fertilization (IVF): Quality of Life and Psychosocial Effects
Reproductive health problems, particularly infertility, affect 48 million couples globally, ranking as the fifth most serious global obstacle for women.
- Conditions
- Infertility, In Vitro Fertilization, Psychosocial Support Systems, Quality of Life
- Trial name
- NCT06515275
- Testing
- Education via video (QR code links)
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Women Infertility
Myo-inositol/D-chiro-inositol Ratio in Follicular Fluid
Considering the importance assumed by follicular microenvironment for a proper oocyte development, this study is a prospective observational clinical trial which aims to evaluate whether the embryo blastocyst quality may be…
- Trial name
- NCT03055442
- Testing
- Dosage of myo-inositol, Dosage of D-chiro-inositol
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Infertility
Clinical Outcomes of Slow Developing Blastocysts
This study evaluates which transfer strategy will result in a higher probability of pregnancy in patients whose single best day 5 embryo resulting from an IVF cycle is classified as expansion grade <4 by Gardner and Schoolcraft…
- Trial name
- LATEBLOOM (NCT03360097)
- Testing
- Frozen Embryo Transfer
- Where
- Spain
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Pregnancy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing Embryo Transfer
The present study is designed to test the hypothesis that acupuncture, before and after embryo transfer, significantly improves pregnancy rates, compared to embryo transfer with sham acupuncture and no acupuncture at all.
- Trial name
- AcuIVF (NCT00722462)
- Testing
- Active acupuncture
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Fertility Centre
Cognitive Behavioral Therapy, Hormone Disturbance
Effectiveness of CBT in Improving Psycho-Neuro-Endocrine Factors in Women Following In Vitro Fertilization Program
The goal of this clinical trial is to learn if Cognitive Behavioral Therapy (CBT) can improve psychological, neurological, and hormonal aspects in women undergoing In Vitro Fertilization (IVF).
- Conditions
- Cognitive Behavioral Therapy, Hormone Disturbance, In Vitro Fertilization
- Trial name
- NCT06521957
- Testing
- Cognitive Behavioral Therapy
- Where
- Indonesia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Invitro Fertilization, Diminished Ovarian Reserve
Effect of Follicular Flushing in Patients With Mono-follicular Growth Undergoing In Vitro Fertilization
Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle.
- Conditions
- Invitro Fertilization, Diminished Ovarian Reserve, Oocyte
- Trial name
- NCT03831542
- Testing
- direct follicular aspiration, follicular flushing
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity
1. Leutinizing hormone (LH) has been demonstrated to exert variable physiological actions during menstrual cycle at appropriate plasma levels' 2.
- Trial name
- LH/M2-Oocyte (NCT01595334)
- Testing
- Cetrorelix, Luprolide Acetate
- Where
- 3 sites in India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre
In Vitro Fertilization
Replacement of Fresh Embryo Transfers (ETs) by Frozen Embryo Transfers (FETs) Using Vitrification
Cryopreservation of all embryos and transferring them subsequently in assisted reproductive technology (ART) cycles to improve outcome.
- Trial name
- NCT00823121
- Testing
- freezing embryos by vitrification, fresh embryo transfers, buserelin
- Where
- Iran
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility