Clinical trials: malaria
Uncomplicated Plasmodium Falciparum Malaria
Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo
Malaria remains a public health concern, despite efforts that are invested in the disease control. The Democratic Republic of the Congo (DRC) is one of the most affected countries in Sub Saharan Africa.
- Trial name
- TES2022 (NCT06076213)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 7 sites in Democratic Republic of the Congo
- Volunteers
- 1,260 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Malaria
Open-Label Study to Assess Meplazumab in Adult Patients Diagnosed with Plasmodium Falciparum
This phase 2a open-label study to assess Meplazumab in adult patients diagnosed with Plasmodium falciparum
- Trial name
- NCT06040346
- Testing
- Meplazumab for Injection
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
Malaria, HIV
Antimalarial Pharmacology in Children and Pregnant Women in Uganda
The burden of malaria is greatest in children and pregnant women in sub-Saharan Africa. Malaria is one of the most important infectious diseases in the world.
- Trial name
- NCT01717885
- Where
- Uganda
- Volunteers
- 473 people
- Sponsor
- University of California, San Francisco
Malaria
Community Dynamics of Malaria Transmission in Humans and Mosquitoes at Maferinyah Sub-Prefecture, Guinea
Background: Half of the world s population is at risk of malaria. In 2015, there were 214 million cases of malaria and 438,000 deaths. A transmission-blocking vaccine (TBV) could help end the disease.
- Trial name
- NCT04969913
- Where
- 2 sites in United States, Guinea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in Mali
Background: Malaria affects many people in Mali and other parts of Africa. It is spread by mosquito bites. Malaria can make people sick or can lead to death.
- Trial name
- NCT03917654
- Testing
- Pfs230D1M-EPA/AS01, HAVRIX, TYPHIM Vi (Salmonella typhi vaccine)
- Where
- Mali
- Volunteers
- 1,301 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Anemia
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NNP (NCT03931473)
- Testing
- Bed nets
- Where
- Benin
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533.
Phase 1, single -centre study in 2 parts. The study designs for each part are well established for first-in-human studies and are appropriate to assess safety, tolerability and preliminary pharmacokinetics.
- Trial name
- NCT04323306
- Testing
- MMV688533
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Covid19, Paludism
Malaria as a Protection Factor Against Severe COVID-19 (Known as SARS-COV-2) in the Democratic Republic of Congo (Palu-COVID)
In this study, the investigators will explore the reasons for the apparently lower proportion of severe COVID-19 cases in many sub-Sahara African countries.
- Trial name
- Palu-COVID (NCT05012280)
- Where
- Democratic Republic of the Congo
- Volunteers
- 238 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Newborn Resuscitation, Severe Malnutrition
Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania
The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric…
- Conditions
- Newborn Resuscitation, Severe Malnutrition, Severe Malaria, Severe Pneumonia
- Trial name
- PACE (NCT06635733)
- Testing
- Rhapsode Capable™ Platform (Intervention Group), Paper-based ISP (Control Group)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Stanford University
Vivax Malaria, Plasmodium Vivax
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
Health care facility based, randomized, controlled, open label, superiority trial with 3 arms
- Conditions
- Vivax Malaria, Plasmodium Vivax, Malaria, Vivax, Malaria Relapse
- Trial name
- EFFORT (NCT04411836)
- Testing
- Tafenoquine, Primaquine
- Where
- 6 sites in Cambodia, Ethiopia and 2 more
- Volunteers
- 960 people
- Sponsor
- Menzies School of Health Research
Malaria, Malaria,Falciparum
A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
Malaria is a major public health problem. There were around 240 million cases of malaria and 627,000 deaths worldwide in 2020. Most of the deaths are in children under five living in Africa.
- Conditions
- Malaria, Malaria,Falciparum, Protozoan Infections, Parasitic Disease
- Trial name
- NCT06141057
- Testing
- Matrix M with RH5.1
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire
This study evaluates the benefit to use 1) insecticide residual sprayings, 2) larvicides, 3) Ivermectin for domestic animals and 4) behaviour change communication strategy to complement the universal coverage with LLINs through a…
- Trial name
- REACT (NCT03074435)
- Testing
- Indoor residual sprayings, Larvicide, BCC
- Where
- 2 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 15,776 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Malaria, HIV/AIDS
Improving Maternal heAlth by Reducing Malaria in African HIV Women
Trial to evaluate the safety and efficacy of DHA-PPQ for Intermittent Preventive Treatment (IPTp) in HIV-infected pregnant women receiving cotrimoxazole prophylaxis (CTXp) and antiretroviral (ARV) drugs and using long lasting…
- Conditions
- Malaria, HIV/AIDS, Pregnancy Related
- Trial name
- MAMAH (NCT03671109)
- Testing
- Dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 2 sites in Gabon, Mozambique
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Malaria,Falciparum
Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali
The purpose of this study is to compare the gametocytocidal and transmission reducing activity of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine-amodiaquine (ALAQ) with and without a single dose of 0.25mg/kg primaquine…
- Trial name
- NECTAR4 (NCT05550909)
- Testing
- Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine
- Where
- Mali
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Uncomplicated Malaria, Asymptomatic Condition
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
Malaria is caused by protozoan parasites of the genus Plasmodium and it is the most important parasitic disease in terms of mortality and morbidity.
- Conditions
- Uncomplicated Malaria, Asymptomatic Condition, Falciparum Malaria
- Trial name
- ZYFER-1 (NCT05911828)
- Testing
- ZY19489 + Ferroquine (FQ)
- Where
- Gabon
- Volunteers
- 36 people
- Sponsor
- Zydus Lifesciences Limited
Malaria,Falciparum, Child, Only
Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study
A double-blind, individual randomised trial will be undertaken in children under five years of age living in areas of Burkina Faso or Mali where the transmission of malaria is intense and highly seasonal to determine whether…
- Trial name
- RTSS-SMC (NCT04319380)
- Testing
- Tetanus/diphtheria toxoids, SMC with SP+AQ, RTS,S/AS01
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 5,098 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implementation of the RTS,S/AS01E Candidate Vaccine
The purpose of this pre-licensure cohort study was to estimate the incidence of adverse events of special interest (AESI), other adverse events (AE) leading to hospitalisation or death, meningitis and malaria in sub-Saharan…
- Trial name
- NCT02374450
- Testing
- Blood collection
- Where
- 5 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 36,366 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria Infection, Pregnancy
Diagnostic Access to Self-Care and Health Services in Low and Middle Income Countries (DASH) - Phase II
Our primary goal is to determine if on-demand, home-based rapid testing, or rapid testing done by a community health worker (CHW) results in people testing for diseases more frequently and getting care more quickly.
- Conditions
- Malaria Infection, Pregnancy, HIV, Diabetes
- Trial name
- DASH (NCT06588790)
- Testing
- Home-based rapid testing, Community health worker rapid testing
- Where
- 3 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Malaria
Improving Knowledge, Attitudes and Practices for Malaria Prevention in the Embera Katio Population
Objective: To evaluate the effectiveness of an educational intervention compared to regular education in improving knowledge, attitudes and practices (KAP) for the prevention of malaria among indigenous people of the Embera Katío…
- Trial name
- NCT06590597
- Testing
- EDUCATIONAL INTERVENTION FOR MALARIA PREVENTION
- Where
- Colombia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Malaria, Malaria, Vivax
Short Course Radical Cure of P. Vivax Malaria in Nepal
This study is designed as a multicentre randomized, open label trial to assess the safety and efficacy of a low dose short course PQ treatment (3.5mg/kg total dose given over 7 days) in glucose-6-phosphate dehydrogenase (G6PD)…
- Conditions
- Malaria, Malaria, Vivax, Malaria,Falciparum
- Trial name
- NCT04079621
- Testing
- primaquine
- Where
- 2 sites in Nepal
- Volunteers
- 27 people
- Sponsor
- Menzies School of Health Research