Clinical trials: malaria
Severe Malaria
Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial
Despite the use of highly effective anti-malarial medications, 10-30% of African children with severe malaria will die, underscoring the need for adjunctive therapies that can be applied in endemic areas.
- Trial name
- NCT01255215
- Testing
- Inhaled Nitric Oxide
- Where
- Uganda
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Malaria, Malaria Vaccine, Insecticide-treated Bednets
RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi
The overall goal of this study is to assess the impact of RTS,S (malaria) vaccination and PBO nets on malaria infection and transmission, independently and how they interact when they are introduced together.
- Trial name
- RTSS/PBO (NCT04327440)
- Testing
- RTS,S/AS01 malaria vaccine, PBO bed nets
- Where
- Malawi
- Volunteers
- 1,691 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Malaria,Falciparum
Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania
Malaria is a major public health problem in Africa. An important way to control the disease is by Indoor Residual Spraying of insecticide in houses. Insecticide resistance has become a major problem.
- Trial name
- NCT05150808
- Testing
- IRS insecticide: Vectron T500
- Where
- 2 sites in Tanzania, United Kingdom
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Severe Malaria
Very Severe Malaria Treated by Intravenous Artesunate
In endemic areas, Plasmodium falciparum malaria exacts a huge public health toll, causing close to half a million deaths each year. In non-endemic industrialized areas, imported malaria may develop.
- Trial name
- Palustar (NCT04516317)
- Testing
- None (Observational study Group intravenous artesunate), None (Observational study Group intravenous quinine)
- Where
- France
- Volunteers
- 578 people
- Sponsor
- Dr Fabrice BRUNEEL
Malaria
Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy Subjects
This was a randomized, subject and investigator-blinded, placebo-controlled, single and multiple ascending intravenous (iv) dose study in healthy subjects to assess the safety and tolerability of KAE609 given in the vein.
- Trial name
- NCT04321252
- Testing
- KAE609
- Where
- Belgium
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Malaria
ANC & Malaria Diagnostic in Pregnancy
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions…
- Trial name
- AQUAMOD (NCT01703884)
- Testing
- ASAQ
- Where
- Burkina Faso
- Volunteers
- 5,254 people
- Sponsor
- Centre Muraz
Flavivirus Infection, Alphavirus Infections
The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
The study project can be divided into two parts: (1) health screening for the community and (2) clinical diagnosis and treatment for patients at National Referral Hospital (NRH) in Solomon islands.
- Conditions
- Flavivirus Infection, Alphavirus Infections, Malaria, Parasitic Disease
- Trial name
- NCT01080989
- Testing
- diagnosis, treatment and education
- Where
- Taiwan
- Volunteers
- 1,477 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Malaria, Placental Malaria
Malaria Rapid Diagnostic Tests (RDTs) in Pregnancy: Detection of Placental Malaria
This study seeks to determine whether screening pregnant women for malaria with malaria rapid diagnostic tests (RDTs) may detect placental infection and predict risk of poor birth outcomes due to malaria in areas of varied…
- Conditions
- Malaria, Placental Malaria, Malaria in Pregnancy
- Trial name
- NCT01555255
- Where
- 2 sites in Burkina Faso, Uganda
- Volunteers
- 1,205 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal
The purpose of this trial is to compare the acceptability, efficacy and safety of three alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent malaria in children.
- Trial name
- NCT00529620
- Testing
- sulfalene-pyrimethamine plus amodiaquine, dihydroartemisinin plus piperaquine, sulfadoxine pyrimethamine plus piperaquine
- Where
- Senegal
- Volunteers
- 1,833 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Mefloquine Bioequivalence Among 3 Commercially Available Tablets.
The objective of this study was to determine the bioequivalence among three commercial tablet formulations of MQ, i.e. Lariam, Mephaquin, and Mefloquine-(AC Farma) when given in combination with artesunate.
- Trial name
- NCT00544024
- Where
- Peru
- Volunteers
- 39 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Pregnancy
Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women
Malaria in pregnancy is potentially fatal to both the mother and the foetus particularly in the primigravidae. Implementation of appropriate control and preventive measures is challenged by the fact that malaria infection in…
- Trial name
- NCT00131703
- Testing
- Amodiaquine, Sulphadoxine-pyrimethamine, Chloroquine
- Volunteers
- 900 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Anti-Malarial Drug Resistance in Cameroon
The project is a three-armed study designed to evaluate the efficacy of amodiaquine(AQ), sulphadoxine-pyrimethamine(SP) and(AQ+SP) in three sites in Cameroon that differ in their baseline characteristics for malaria.
- Trial name
- NCT00146718
- Testing
- Amodiaquine and Sulphadoxine/Pyrimethamine
- Volunteers
- 755 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Seasonal Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine in Children in Mali
Recent, randomized controlled trials conducted in areas of perennial malaria transmission have shown that intermittent preventive treatment (IPT) given at the time of vaccination reduced the incidence of the first episode of…
- Trial name
- NCT00623155
- Testing
- Seasonal IPT in children - Sulfadoxine-pyrimethamine
- Where
- Mali
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Uncomplicated Plasmodium Falciparum Malaria
Antimalarial Drug Resistance With Assessment of Transmission Blocking Activity
This is a two-arm, open label Treatment Study comparing the efficacy, safety, tolerability and pharmacokinetics of a three-day course of Dihydroartemisinin-Piperaquine (DP) with or without single-dose primaquine in patients with…
- Trial name
- NCT01849640
- Testing
- DHA-piperaquine and Primaquine
- Where
- Cambodia
- Volunteers
- 150 people
- Sponsor
- David Saunders
Anemia, Malaria
Perennial Malaria Chemoprevention (PMC) in Cameroon
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05889052
- Testing
- Sulfadoxine pyrimethamine
- Where
- Cameroon
- Volunteers
- 2,138 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Falciparum Malaria
Biological Mechanisms in Afebrile P. Falciparum Malaria
This project aims to disentangle the role of host immune resistance and disease tolerance in afebrile malaria infections, with the goal of guiding context-adapted tactics to target this hidden reservoir, as well as to develop new…
- Trial name
- AsintMal (NCT04422015)
- Testing
- No intervention
- Where
- Mozambique
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Alfredo Mayor
Malaria,Falciparum
Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin
Seasonal Malaria Chemoprevention (SMC) for children less than five years old is one the high impact interventions against malaria in sub-Saharan Africa (SSA).
- Trial name
- NCT04149106
- Testing
- Sulfadoxine pyrimethamine + Amodiaquin, Dihydroartemisinin piperaquin
- Where
- Mali
- Volunteers
- 4,556 people, healthy volunteers welcome
- Sponsor
- University Clinical Research Center, Mali
Malaria,Falciparum
Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model
This study follows a First-In-Human dose-escalation study of MMV390048 (5 to 120 mg MMV390048 powder-in-bottle formulation), a formulation bioavailability study to establish suitable tablet formulation, and a two-part…
- Trial name
- NCT03195387
- Testing
- MMV390048
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Evaluate the Safety and Efficacy of Plasmodium Falciparum Malaria Protein 010 (FMP010) Administered With Adjuvant AS01B
The purpose of this study is to determine whether an investigational malaria vaccine is safe and induces an immune response against malaria when tested in adults living in the United States.
- Trial name
- NCT02458092
- Testing
- Plasmodium falciparum Malaria Protein 010 (FMP010), Rabipur
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
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