Clinical trials: malaria
Malaria
Food-Effect Bioavailability Study of AQ-13, a Candidate Antimalarial
The purpose of this study is to test the safety of a 2100 mg dose of AQ-13, a new candidate antimalarial active against drug-resistant P.
- Trial name
- NCT00455494
- Testing
- AQ-13
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Malaria,Falciparum
MSP3-CRM-Vac4All/ Alhydrogel® Vaccine
Two-arm, randomized, double-blinded and controlled clinical trial to first assess the safety and tolerability of the vaccine in a Phase 1b trial and proceed to assess its efficacy against clinical malaria in young children living…
- Trial name
- NCT05776017
- Testing
- MSP3-CRM-Vac4All/ Alhydrogel®, Anti-Rabies Vaccine
- Where
- Mali
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Vac4All
Malaria,Falciparum, Plasmodium Falciparum
Safety and Protective Efficacy of Pb(PfCS@UIS4)
In the underlying study, a genetically modified P. berghei parasite is used. P. berghei is one of the four Plasmodium species that causes malaria in rodents. The hypothesis is that immunization of humans with P.
- Conditions
- Malaria,Falciparum, Plasmodium Falciparum, Plasmodium Berghei, Controlled Human Malaria Infection (CHMI)
- Trial name
- PbVac (NCT03138096)
- Testing
- Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Vivax
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
The aim of this study is to collect efficacy and safety data to support the registration of tafenoquine in India.
- Trial name
- NCT06666491
- Testing
- Tafenoquine, Primaquine, Chloroquine
- Where
- 5 sites in India
- Volunteers
- 324 people
- Sponsor
- GlaxoSmithKline
Anemia, Anemia, Iron-Deficiency
Lucky Iron Fish Home Fortification of Iron
The purpose of this research is to determine if cooking with an iron ingot called the Lucky Iron Fish (LIF) increases the hemoglobin status in women of childbearing age living in Preah Vihear, Cambodia.
- Conditions
- Anemia, Anemia, Iron-Deficiency, Hemoglobinopathies
- Trial name
- NCT02341586
- Testing
- Lucky Iron Fish - home fortification system, 18 mg elemental iron, Nutrition Education
- Where
- Cambodia
- Volunteers
- 340 people
- Sponsor
- University of British Columbia
Uncomplicated Falciparum Malaria
Azithromycin Combination Therapy for the Treatment of Uncomplicated Falciparum Malaria in Bangladesh
The purpose of this study is to investigate the efficacy of azithromycin combination therapy with artesunate for the treatment of uncomplicated falciparum malaria in Bangladesh.
- Trial name
- NCT00356005
- Testing
- azithromycin plus artesunate, Artesunate
- Where
- Bangladesh
- Volunteers
- 228 people
- Sponsor
- Medical University of Vienna
Plasmodium Falciparum Infection
Optimising Operational Use of Artemether-lumefantrine Comparing 3 Day Versus 5 Day
This is a randomised two arm study, comparing artemether-lumefantrine 3 days and 5 days treatment. Patients will be randomised in blocks of ten to one of the two treatment arms.
- Trial name
- AL3vs5 (NCT02020330)
- Testing
- Artemether-lumefantrine 3 days, Artemether-lumefantrine 5 days
- Where
- Burma
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Malaria
The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children
The aim of this study was to determine the effect of combining vitamin A (VA), zinc (Z) and multivitamins (MV- A, B1, B2, B6, B12, C, D and E) on malaria morbidity
- Trial name
- NCT02878265
- Testing
- Vitamin A, Vitamin A and ZInc, Vitamin A , Zinc and Multivitamin
- Where
- Ghana
- Volunteers
- 547 people
- Sponsor
- University of Ghana
Malaria
Efficacy of Sulfadoxine-Pyrimethamine for Treating Malaria in Gabonese Children
IPTi, a strategy whereby infants are provided treatment doses of antimalarials at routine vaccination visits, has been shown to significantly reduce malaria and anemia in two studies in Tanzania.
- Trial name
- NCT00453856
- Testing
- Sulfadoxine Pyrimethamine
- Where
- Gabon
- Volunteers
- 139 people
- Sponsor
- Albert Schweitzer Hospital, Netherlands
Malaria
Safety and Immunogenicity of Novel Vaccination Schedules With Malaria Vaccines AdCh63 ME-TRAP and MVA ME-TRAP
This is an open label phase I study, to assess the safety and immunogenicity of novel schedules for vaccination with the candidate malaria vaccines AdCh63 ME-TRAP and MVA ME-TRAP.
- Trial name
- NCT01364883
- Testing
- Vaccination Schedule One, Vaccination Schedule Two, Vaccination Schedule Three
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Fever, Anaemia
Acceptability and Cost Effectiveness of Home Based Management of Fever: Different Strategies
Malaria remains a major cause of morbidity and mortality particularly among children < 5 years in Uganda. Due to inaccessibility many children die before they reach the health facility.
- Conditions
- Fever, Anaemia, Malaria
- Trial name
- NCT00259142
- Testing
- Chloroquine, sulphadoxine-pyrimethamine
- Where
- Uganda
- Volunteers
- 1,314 people
- Sponsor
- DBL -Institute for Health Research and Development
Malaria
Clinical Evaluation of Mosquito Coils to Control Malaria in China
Although mosquito coils are widely used, there is no robust evidence that their use can provide clinical reduction in malaria. This study will randomise 4 groups of 400 houses, each with 5 people, in rural China and monitor cases…
- Trial name
- NCT00442442
- Testing
- mosquito coils, LLIN
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Intermittent Preventive Treatment
Intermittent Preventive Treatment of Malaria in Schoolchildren
This will be a randomized, single-blinded, placebo-controlled trial to evaluate the efficacy, safety and tolerability of antimalarial regimens in healthy schoolchildren.
- Trial name
- NCT00852371
- Testing
- sulfadoxine-pyrimethamine, amodiaquine + sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine
- Volunteers
- 780 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Clinical Malaria
Cotrifazid Safety and Efficacy Against Malaria
The purpose of this study was to assess the safety and efficacy of Cotrifazid to treat uncomplicated resistant malaria and to compare the outcome with mefloquine or quinine+sulfadoxine/pyrimethamine (SP)
- Trial name
- NCT00322907
- Testing
- Cotrifazid vs mefloquine or quinine+SP
- Where
- Papua New Guinea
- Volunteers
- 330 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Malaria
Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan
This study aims to explore whether SMC is an effective intervention in the context of Northen Bahr el Gazal state, South Sudan. It also aims to assess the protective efficacy of the antimalarials used in SMC in the target…
- Trial name
- NCT05471544
- Testing
- Sulfadoxine pyrimethamine, Amodiaquine
- Where
- South Sudan
- Volunteers
- 3,575 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Malaria, Anemia
Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants
The purpose of this study is to assess the effectiveness of Intermittent Preventive Treatment in Infants (IPTi) with Sulfadoxine-Pyrimethamine to reduce the numbers of malaria attacks, episodes of anemia, and the overall…
- Trial name
- NCT00206739
- Testing
- Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
- Where
- Ghana
- Volunteers
- 1,070 people, healthy volunteers welcome
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Malaria, Falciparum, Malaria, Vivax
A Randomised Trial of Artekin and Artesunate & Amodiaquine for Uncomplicated Malaria in Timika, Papua, Indonesia.
The primary aim of the comparative trial is to assess the relative safety and efficacy of two artemisinin containing regimens: amodiaquine plus artesunate (AAQ) and artekin both administered once daily for 3 days.
- Trial name
- NCT00157885
- Testing
- Amodiaquine plus artesunate; Artekin
- Where
- Indonesia
- Volunteers
- 400 people
- Sponsor
- Menzies School of Health Research
Uncomplicated Plasmodium Falciparum Malaria
Extended Duration Artemether-lumefantrine Treatment for Malaria in Children
This project determines the pharmacokinetic/pharmacodynamic (PK/PD) of an extended artemether-lumefantrine (AL) dosing regimen in HIV-infected children on efavirenz (EFV)-based antiretroviral therapy (ART) that is designed to…
- Trial name
- EXALT (NCT03453840)
- Testing
- Artemether-lumefantrine
- Where
- 2 sites in Uganda
- Volunteers
- 305 people
- Sponsor
- University of California, San Francisco
Plasmodium Falciparum, Asymptomatic Parataemia
Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission
The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission.
- Conditions
- Plasmodium Falciparum, Asymptomatic Parataemia, Sub Patent Parasitaemia
- Trial name
- NCT00646126
- Testing
- Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS)
- Where
- Sudan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tropical Medicine Research Institute
Uncomplicated Malaria
Malaria Therapeutic Efficacy Study, Rwanda
WHO recommends that Therapeutic Efficacy Studies (TES) for 1st and 2nd line antimalarial medicines should be routinely carried out and data made available for decision-making due to the threat of emergence and spread of…
- Trial name
- NCT04767217
- Testing
- artemether-lumefantrine (ALN), dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 3 sites in Rwanda
- Volunteers
- 528 people
- Sponsor
- Jhpiego
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