Clinical trials: malaria
Malaria
Study to Assess Efficacy of New Malaria Vaccine Candidates AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP & MVA ME-TRAP
This study aims to test the safety and efficacy of six new malaria vaccines - AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP \& MVA ME-TRAP.
- Trial name
- NCT01142765
- Testing
- AdCh63 MSP1, MVA MSP1, challenge, AdCh63 AMA1, MVA AMA1, challenge, AdCh63 AMA1, AdCh63 MSP1, MVA AMA1, MVA MSP1, challenge
- Where
- 3 sites in United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum Malaria
Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar
The general objective of this study is to assess the therapeutic efficacy and safety of artesunate + amodiaquine combined with a single low dose of primaquine (0.25 mg/kg) for the treatment of uncomplicated P.
- Trial name
- AcoV (NCT03773536)
- Testing
- Artesunate-amodiaquine given with single low dose primaquine
- Where
- Tanzania
- Volunteers
- 146 people
- Sponsor
- Professor Anders Björkman
Malaria,Falciparum
A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M
This is a Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the malaria vaccine candidates R78C with Matrix-M™, and the combination of RH5.1 and R21 with Matrix-M™, in children aged 5-36 months…
- Trial name
- VAC087 (NCT07183371)
- Testing
- R21, RH5.1, R78C
- Where
- Burkina Faso
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Community Point Distribution of Insecticide Treated Bed Nets
All households in three zones in Zambia's Eastern Province were invited to attend a community point distribution of insecticide treated bed nets (ITNs).
- Trial name
- NCT02517879
- Testing
- Community point distribution, Community health worker hang-up visit
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- IDinsight
Plasmodium Falciparum Infection
PfSPZ Challenge in Non-immune Adults in Baltimore, USA
This is a single center, randomized and controlled human study to optimize controlled human malaria infection (CHMI) administered by direct venous inoculation (DVI).
- Trial name
- NCT02780154
- Testing
- PfSPZ (7G8) Challenge, PfSPZ (NF54) Challenge
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Falciparum
Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
In the Democratic Republic of Congo (DRC), malaria is an important cause of morbidity and mortality. It is estimated that malaria is responsible for 30% of admissions to hospital averaged throughout the country and for 25-30%…
- Trial name
- NCT01567423
- Testing
- ASAQ Winthrop® Sanofi Aventis, Coartem®, Novartis
- Where
- Democratic Republic of the Congo
- Volunteers
- 301 people
- Sponsor
- Epicentre
Malaria
Safety and Pharmacokinetics Study of DM1157 to Treat Malaria
This is a phase 1 trial to evaluate the safety and pharmacokinetics of single and multiple ascending doses and effect of food on the pharmacokinetics of a novel antimalarial drug in healthy adults.
- Trial name
- NCT03490162
- Testing
- DM1157
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Falciparum Malaria
Pharmacokinetic of Mefloquine-Artesunate in Plasmodium Falciparum Malaria Infection in Pregnancy
Malaria in pregnancy is a major public health problem in Sub-Saharan Africa. Over the past decades, P. falciparum has shown increasing resistance to chloroquine and Sulphadoxine-Pyrimethamine, which has prompted a change in…
- Trial name
- NCT00701961
- Testing
- Mefloquine-artesunate
- Where
- Burkina Faso
- Volunteers
- 48 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Plasmodium Falciparum Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Myanmar
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05025761
- Testing
- Personal protection package
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Malaria
A Study to Assess the Immunogenicity, Tolerability and Safety of a Malaria Vaccine and Also Its Protective Efficacy in a Malaria Challenge Model
The purpose of this study is to assess the safety, tolerability and immunogenicity of two dose levels (1x10^10 and 5x10^10 virus particles (vp)) of the adenovirus serotype (Ad) Ad35.CS.01/Ad26.CS.01 prime-boost malaria candidate…
- Trial name
- NCT01397227
- Testing
- Ad35.CS.01/Ad26.CS.01 low dose (1 x 10^10 vp), Ad 35.CS.01/Ad 26.CS.01 high dose (5 x 10^10 vp)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Severe Falciparum Malaria
Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
acidosis, acute renal failure and acute pulmonary oedema are common, and frequently fatal, manifestations of severe P. falciparum malaria.
- Trial name
- PRiSM (NCT00692627)
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Uncomplicated Falciparum Malaria
Efficacy and Safety of ASAQ and PD for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania
The World Health Organization recommends regular surveillance of antimalarial efficacy to monitor the performance of different drugs.
- Trial name
- GF-TES-2017 (NCT03431714)
- Testing
- Artesunate amodiaquine
- Where
- Tanzania
- Volunteers
- 333 people
- Sponsor
- National Institute for Medical Research, Tanzania
Malaria
Frequency and Distribution of Mixed Falciparum-vivax Infections in French Guiana
Malaria is still endemic in the interior of French Guiana. mixed infections by 2 or more different malaria parasites lead to complex and potentially harmfull therapeutic problems.
- Trial name
- MixMal (NCT02903758)
- Testing
- cross sectional
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier de Cayenne
Uncomplicated Plasmodium Falciparum Malaria
Rapid Diagnostic Testing and Artemisinin-Based Combination Therapy for Uncomplicated Malaria by Community Health Workers
The purpose of this study is to evaluate the efficiency of a rapid diagnostic test (Paracheck Pf) for the diagnosis of uncomplicated Plasmodium falciparum malaria by community health workers at village level in Tanzania and how…
- Trial name
- NCT00301015
- Testing
- Rapid diagnostic test for malaria
- Where
- Tanzania
- Volunteers
- 3,005 people
- Sponsor
- Karolinska University Hospital
Malaria
Evaluating the Clinical Performance and Usability of Novel Malaria RDTs in Brazil
Prospective cross-sectional diagnostic accuracy study with 1,000 patient participants and 30 lay provider/health care worker participants. The patient participant population will be recruited at clinics.
- Trial name
- NCT05317117
- Testing
- NxTek™ Malaria P.f plus Rapid Diagnostic Test (RDT) and NxTek™ Malaria P.f/P.v RDT
- Where
- Brazil
- Volunteers
- 1,030 people, healthy volunteers welcome
- Sponsor
- PATH
Anemia, Inflammation
Acute vs. Delayed Iron Therapy: Effect on Iron Status, Anemia and Cognition
The research questions to be answered by this study are: 1. Is treatment with iron more effective at improving anemia if given at the time of a malaria episode or 1 month after the episode? 2.
- Conditions
- Anemia, Inflammation, Malaria Morbidity, Cognitive Development
- Trial name
- NCT01093989
- Testing
- Ferrous Sulphate Syrup
- Where
- Uganda
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Bloodstream Infection, Health Care Utilization
Health Itinerary of Young Children With Suspected Bloodstream Infection in Kisantu General Referral Hospital, DR Congo
Bloodstream infections are frequent in children admitted to the hospital for severe febrile illness in sub-Saharan Africa.Ongoing blood culture surveillance at Kisantu Hospital showed non-typhoidal Salmonella (NTS) as the first…
- Conditions
- Bloodstream Infection, Health Care Utilization, Malaria,Falciparum, Salmonella Infection Non-Typhoid
- Trial name
- HIT BSI (NCT04289688)
- Where
- Democratic Republic of the Congo
- Volunteers
- 784 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Bioavailability of the Fixed Combination of Amodiaquine and Artesunate Under Fed & Fasted Conditions
Primary Objective: to evaluate the interaction with food after a single oral dose of a fixed combination of amodiaquine (AQ) and artesunate (AS) (COARSUCAM™) in healthy male subjects Secondary Objective: to assess the clinical…
- Trial name
- NCT00386503
- Testing
- Artesunate + Amodiaquine
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sanofi
Malaria
Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination
This is a community-based cluster-randomized trial in which a novel approach to interrupt residual malaria transmission by mass drug administration (MDA) with ivermectin (IVM) combined with dihydroartemisinin-piperaquine (DP)…
- Trial name
- MASSIV (NCT03576313)
- Testing
- dihydroartemisinin-piperaquine (DP), ivermectin (IVM), standard malaria control interventions only
- Where
- The Gambia
- Volunteers
- 4,939 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Stunting, Underweight
Spirulina Supplementation and Infant Growth, Morbidity and Motor Development
Background: In developing countries, micronutrient deficiency in infants is associated with growth faltering, morbidity, and delayed motor development.
- Conditions
- Stunting, Underweight, Pneumonia, Pneumocystis, Cough
- Trial name
- NCT03523182
- Testing
- Spirulina, Control
- Where
- Zambia
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Programme Against Malnutrition
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