Clinical trials: malaria
Malaria
Effectiveness of Intermittent Preventive Treatment for Malaria in Children
Intermittent preventive treatment for malaria in children (IPTc) is a promising new approach to malaria control. Preliminary studies of IPTc in Senegal and Mali indicate that this approach can be very effective.
- Trial name
- NCT00119132
- Testing
- artesunate-amodiaquine, sulphadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 2,602 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Kintampo Trial of Combination Therapy for Malaria
Case management is one of the key strategies for malaria control in most endemic countries. Plasmodium falciparum malaria is becoming resistant to commonly used and cheap antimalarial drugs such as chloroquine, amodiaquine, and…
- Trial name
- NCT00119145
- Testing
- artesunate-amodiaquine, coartem, artesunate-lapdap
- Where
- Ghana
- Volunteers
- 510 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Intermittent Preventative Treatment With Sulfadoxine-Pyrimethamine in Gambian Multigravidae
Malaria is particularly harmful during pregnancy causing anemia in the mother and low birth weight which, in turn, increases infant mortality.
- Trial name
- NCT00120809
- Testing
- Sulfadoxine-pyrimethamine
- Where
- The Gambia
- Volunteers
- 3,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Folic Acid Supplementation in Gambian Primigravidae
Supplementation with folic acid and iron is recommended for pregnant women in order to prevent them from developing anemia. In malaria endemic areas of Africa, the World Health Organization (WHO) now recommends that pregnant…
- Trial name
- NCT00120822
- Testing
- Folic acid
- Where
- The Gambia
- Volunteers
- 1,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Malaria Candidate Vaccines FP9 Circumsporozoite (CS) and MVA CS in Adult Gambian Men
Animal and human studies have shown that the prime-boost immunization strategy using malaria antigens expressed in plasmid or viral vectors induces strong cellular immune responses.
- Trial name
- NCT00121771
- Testing
- FP9 CS, MVA CS
- Where
- The Gambia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Malaria Infection Diagnosed by Polymerase Chain Reaction (PCR) as a Means of Evaluating Pre-erythrocytic Candidate Malaria Vaccines
The ability to test candidate pre-erythrocytic stage malaria vaccines, using a well-established sporozoite challenge model, in a field setting with group sizes of tens rather than hundreds of volunteers would greatly facilitate…
- Trial name
- NCT00121823
- Testing
- FP9 ME-TRAP, MVA ME-TRAP
- Where
- The Gambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, HIV Infections
Influence of Chloroquine on HIV Viral Load Among Pregnant Women in Uganda
There is conflicting evidence regarding the influence of HIV infection on the success of malaria prevention in pregnancy and effect on pregnancy outcome.
- Trial name
- NCT00132535
- Testing
- sulfadoxine-pyrimethamine intermittent preventive treatment, chloroquine
- Where
- Uganda
- Volunteers
- 2,548 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese Children
A recent study has shown that the administration of a single dose of sulfadoxine/pyrimethamine plus artesunate to Senegalese children on three occasions during a short malaria transmission season reduced the incidence of clinical…
- Trial name
- NCT00132548
- Testing
- Pyrimethamine/sulfadoxine, Amodiaquine, Artesunate
- Where
- Senegal
- Volunteers
- 2,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children
In countries of the Sahel and sub-Sahel, malaria transmission is highly seasonal with nearly all infections occurring during a few months of the year.
- Trial name
- NCT00132561
- Testing
- Sulfadoxine/pyrimethamine and artesunate
- Where
- Senegal
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria in Pregnancy, Birth Weight
Relationships Between the Use of Antimalarial Drugs in Pregnancy and Plasmodium Falciparum Resistance
Plasmodium falciparum resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) continue to spread, impeding control of this important disease.
- Conditions
- Malaria in Pregnancy, Birth Weight, Anaemia
- Trial name
- NCT00140517
- Testing
- sulphadoxine-pyrimethamine, chloroquine
- Where
- Burkina Faso
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Falciparum
Preventing Malaria During Pregnancy in Epidemic-prone Areas.
The purpose of this study is to compare the efficacy and cost-effectiveness of three alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone area of low transmission in the East African…
- Trial name
- NCT00142207
- Testing
- Intermittent preventive treatment:sulphadoxine-pyrimethamine, Insecticide-treated mosquito bed net
- Where
- Uganda
- Volunteers
- 4,775 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Evaluation of Combined Use of ITN's and Insect Repellents Against Malaria
Insecticide Treated Nets (ITN's) offer good protection against malaria in Africa where the vector mosquitoes feed indoors late at night.
- Trial name
- NCT00144716
- Testing
- Insect Repellent plus Insecticide Treated Net
- Volunteers
- 4,250 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Trial of Improved Financial Access to Healthcare in Ghana
Effective control strategies for malaria depend both on preventing disease and on treating those who become infected to prevent significant morbidity and mortality.
- Trial name
- NCT00146692
- Testing
- Free medical treatment
- Where
- Ghana
- Volunteers
- 2,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Anti-Malarial Drug Resistance in Cameroon
The project is a three-armed study designed to evaluate the efficacy of amodiaquine(AQ), sulphadoxine-pyrimethamine(SP) and(AQ+SP) in three sites in Cameroon that differ in their baseline characteristics for malaria.
- Trial name
- NCT00146718
- Testing
- Amodiaquine and Sulphadoxine/Pyrimethamine
- Volunteers
- 755 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Trial of Antimalarial Drugs Used in Pregnancy in Tanzania
Pregnant women are vulnerable to malaria, with significant implications both for their health and for the pregnancy. Sulfadoxine-pyrimethamine (SP) is currently the first line drug for the treatment of malaria in pregnancy in…
- Trial name
- NCT00146731
- Testing
- SP, SP + amodiaquine, AQ + artesunate
- Where
- Tanzania
- Volunteers
- 310 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Navrongo Drug Options for IPT in Pregnancy Trial
In areas of stable transmission, pregnant women, especially during the first and second pregnancies, have an increased susceptibility to Plasmodium falciparum malaria, malaria-related anaemia and an increased risk of having low…
- Trial name
- NCT00146783
- Testing
- Sulphadoxine-pyrimethamine, Sulphadoxine-pyrimethamine, amodiaquine
- Where
- Ghana
- Volunteers
- 3,642 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Febrile Illness
A Randomised Trial of Rapid Diagnostic Tests in the Diagnosis of Malaria in Tanzania
There is clear evidence diagnosis of malaria in much of Africa is sub-optimal and this has a negative impact on patient care. Many of those treated for malaria do not have it.
- Trial name
- NCT00146796
- Testing
- Rapid diagnostic test for malaria
- Where
- Tanzania
- Volunteers
- 2,400 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Falciparum Malaria
ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan
Chloroquine resistant falciparum malaria in Pakistan is prevalent in every malarious area examined. Resistance to the favoured second-line treatment, sulphadoxine-pyrimethamine S/P is rising fast.
- Conditions
- Malaria, Falciparum Malaria, Vivax Malaria
- Trial name
- NCT00158548
- Testing
- SP, chloroquine, amodiaquine, primaquine, artesunate
- Where
- Pakistan
- Volunteers
- 650 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Vivax Malaria
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
To determine whether two cheap antifolates (chlorproguanil-dapsone and sulfadoxine-pyrimethamine) which work against falciparum malaria in this region are sufficiently effective against vivax malaria to be deployed in areas where…
- Trial name
- NCT00158561
- Testing
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone
- Where
- Pakistan
- Volunteers
- 750 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Kilimanjaro IPTi Drug Options Trial
Malaria and anaemia are major causes of morbidity and mortality in children in sub-Saharan Africa. Administration of three courses of sulfadoxine/pyrimethamine (SP) as intermittent preventive treatment (IPTi) to infants when they…
- Trial name
- NCT00158574
- Testing
- sulphadoxine-pyrimethamine, mefloquine, Chlorproguanil-dapsone
- Where
- Tanzania
- Volunteers
- 2,419 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine