Clinical trials: malaria
Malaria
Malaria Survey in Mbarara District, Uganda 2010
Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of…
- Trial name
- NCT01062386
- Where
- Uganda
- Volunteers
- 2,320 people, healthy volunteers welcome
- Sponsor
- Epicentre
Malaria Diagnosis
Validation of RealAmp Method for the Diagnosis of Malaria in Endemic Areas of Brazil
Worldwide, approximately 2 billion people live in areas at risk for malaria with morbidity surpassing 250 million cases, with approximately 800,000 deaths, per year.
- Trial name
- NCT02371395
- Testing
- Realtime amplification (RealAmp)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- Centers for Disease Control and Prevention
Iron Deficiency, Malaria
Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
The purpose of this study is to determine whether iron therapy given to iron-deficient Ugandan children with moderate-to-severe anemia and clinical malaria is better absorbed and incorporated into red blood cells if it is given…
- Conditions
- Iron Deficiency, Malaria, Nutrition, Global Health
- Trial name
- NCT01754701
- Testing
- Immediate iron, Delayed iron
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
P Vivax, Malaria, Vivax
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil
We plan to assess the efficacy of 3 different regimens of chloroquine and primaquine for the treatment of P. vivax infections in Cruzeiro do Sul, Acre, Brazil.
- Trial name
- NCT03610399
- Testing
- Primaquine
- Where
- Brazil
- Volunteers
- 257 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Falciparum
Efficacy and Safety of the Pediatric Formulation of Artemether- Lumefantrine in Children With Uncomplicated P. Falciparum Malaria.
This study will evaluate the safety and efficacy of artemether-lumefantrine against uncomplicated malaria caused P. falciparum in children of 5-35 kg bodyweight.
- Trial name
- NCT00386763
- Testing
- Artemether-lumefantrine
- Where
- 5 sites in Benin, Kenya and 3 more
- Volunteers
- 890 people
- Sponsor
- Novartis
Malaria
Malaria Candidate Vaccines FP9 Circumsporozoite (CS) and MVA CS in Adult Gambian Men
Animal and human studies have shown that the prime-boost immunization strategy using malaria antigens expressed in plasmid or viral vectors induces strong cellular immune responses.
- Trial name
- NCT00121771
- Testing
- FP9 CS, MVA CS
- Where
- The Gambia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Safety and Immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP Vaccines in Malaria Endemic Areas
The purpose of this trial is to assess the safety and immunogenicity of AdCh63 ME-TRAP and MVA ME-TRAP candidate vaccines in healthy adult volunteers in a malaria endemic region.
- Trial name
- NCT01379430
- Testing
- AdCh63 ME-TRAP followed by MVA ME-TRAP
- Where
- Kenya
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
An Extended Follow up of a RTS,S/AS01E Malaria Vaccine Trial
Malaria is one of the leading causes of deaths in children below five years old. Despite antimalarial drugs and insecticide treated bed nets, the established means of treatment and protection, malaria still continues to affect…
- Trial name
- MAL059 (NCT00872963)
- Testing
- RTS,S/AS01E
- Where
- Kenya
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Malaria
Efficacy of Artesunate + Amodiaquine Four Years After Its Introduction in Zanzibar
The purpose of this study is to assess the efficacy of artesuante + amodiaquine four years after its introduction as first line treatment for uncomplicated childhood malaria in Zanzibar.
- Trial name
- NCT00465257
- Testing
- artesunate + amodiaquine
- Where
- Tanzania
- Volunteers
- 110 people
- Sponsor
- Karolinska University Hospital
Malaria,Falciparum, Feasibility
Malaria Vaccine Pilot Evaluation
The RTS,S/AS01 malaria vaccine is being introduced sub-nationally in phased pilot introductions through the EPI programmes in Malawi Ghana and Kenya.
- Conditions
- Malaria,Falciparum, Feasibility, Safety, Mortality
- Trial name
- MVPE (NCT03806465)
- Testing
- Feasibility survey, Sentinel hospital surveillance, Community mortality surveillance
- Where
- 3 sites in Ghana, Kenya and 1 more
- Volunteers
- 30,124 people, healthy volunteers welcome
- Sponsor
- Rafiq OKINE
Malaria
Artemether-lumefantrine for Treatment of P. Falciparum Malaria in Brazil
This is an in vivo evaluation of drug efficacy performed in Cruzeiro do Sul, in the state of Acre, Brazil. A total of 81 participants ≥5 years old with parasitological confirmation of P.
- Trial name
- NCT02600767
- Testing
- Artemether-lumefantrine combination
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria Vivax, Malaria Falciparum
Serological Testing and Treatment for Plasmodium Vivax Malaria: a Trial in Ethiopia and Madagascar
The resilience of P. vivax to malaria elimination efforts is due to its ability to form dormant liver stages (hypnozoites) that reactivate weeks to months after the initial infection causing recurrent episodes of malaria…
- Conditions
- Malaria Vivax, Malaria Falciparum, Plasmodium Vivax, Plasmodium Falciparum
- Trial name
- PvSTATEM (NCT06923592)
- Testing
- PvSeroTAT, Control
- Where
- 2 sites in Ethiopia, Madagascar
- Volunteers
- 19,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Severe Malaria
Monitoring of Molecular Markers of Artemisinin Resistance Through Repeated Cross-sectional Assessments in DR Congo, Nigeria and Uganda
Currently, 16 African countries include the use of pre-referral rectal artesunate (RAS) in their treatment policies. However, guidelines for RAS use vary widely across countries and inappropriate use of RAS as a monotherapy and…
- Trial name
- Caramal DRM (NCT04037332)
- Testing
- Blood sample (combined with malaria RDT) followed by gentoyping analysis
- Where
- 7 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 916 people
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria, Parasitic Diseases
Malaria Elimination Pilot Study in Military Forces in Cambodia
Antimalarial drug resistance has reached critical levels on the Thai-Cambodian border. Many have begun advocating for concerted malaria elimination efforts in Cambodia.
- Trial name
- NCT02653898
- Testing
- DHA-PIP, Primaquine, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Malaria
Effectiveness of Intermittent Preventive Treatment for Malaria in Children
Intermittent preventive treatment for malaria in children (IPTc) is a promising new approach to malaria control. Preliminary studies of IPTc in Senegal and Mali indicate that this approach can be very effective.
- Trial name
- NCT00119132
- Testing
- artesunate-amodiaquine, sulphadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 2,602 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cerebral Malaria, Malarial Retinopathy
Automated Detection of Malarial Retinopathy in Patients Diagnosed With Cerebral Malaria
The focus of the study is performance validation of ASPIRE software device in processing mydriatic retinal images of a patient with clinically diagnosed Cerebral Malaria (CM), to detect malarial retinopathy (MR).
- Trial name
- ASPIRE (NCT06915285)
- Testing
- Automated software for malarial retinopathy detection
- Where
- Malawi
- Volunteers
- 834 people
- Sponsor
- VisionQuest Biomedical LLC
Malaria, Falciparum
Azithromycin Plus Chloroquine Versus Artemether-Lumefantrine For The Treatment Of Uncomplicated P. Falciparum Malaria In Children In Africa
The primary objective is to confirm the hypothesis that azithromycin used in combination with chloroquine is non-inferior to artemether- Lumefantrine for the treatment of symptomatic, uncomplicated malaria due to P.
- Trial name
- NCT00677833
- Testing
- Azithromycin plus Chloroquine, Artemether-lumefantrine
- Where
- 7 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 361 people
- Sponsor
- Pfizer
Malaria
A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria
The purpose of this study is to determine the efficacy of sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine alone in the treatment of uncomplicated malaria.
- Trial name
- NCT00203814
- Testing
- Sulfadoxine-pyrimethamine, Artesunate plus sulfadoxine-pyrimethamine
- Where
- 2 sites in Mozambique
- Volunteers
- 280 people
- Sponsor
- University of Cape Town
Malaria, Malaria Vaccine
Knowledge and Attitude Among Healthcare Workers Towards Malaria Vaccine, Sudan 2025.
This study assesses Sudanese healthcare workers' knowledge and attitudes toward the malaria vaccine in 2025, considering demographic and professional factors.
- Trial name
- NCT07194499
- Testing
- No interventions
- Where
- Sudan
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Research and Publication office
Malaria, Malaria, Vivax
ACT vs CQ With Tafenoquine for P. Vivax Mono-infection
In this area of Greater Mekong Subregion (GMS), vivax malaria is the most common kind of malaria. It can stay very long in the liver, and come out later to make another episode of illness.
- Conditions
- Malaria, Malaria, Vivax, Plasmodium Vivax Malaria
- Trial name
- ACTQ (NCT05788094)
- Testing
- Dihydroartemisinin-piperaquine plus tafenoquine (450 mg adult dose), Chloroquine plus Tafenoquine (450 mg adult dose), Artemether-Lumefantrine plus Tafenoquine (450 mg adult dose)
- Where
- Thailand
- Volunteers
- 606 people
- Sponsor
- Shoklo Malaria Research Unit
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