Clinical trials: microRNA
Glycogen Depletion
Carbohydrate Availability and microRNA Expression
This investigation will examine the impact of skeletal muscle glycogen stores on skeletal muscle and circulating microRNA expression and exogenous carbohydrate oxidation.
- Trial name
- NCT03250234
- Testing
- Adequate Carbohydrate, Low Carbohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- MiGIC (NCT07224750)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Primary Immune Thrombocytopenia
Plasma microRNA Levels and Some Cytokines Expression in Patients With ITP Primary Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts with or without mucocutaneous bleeding (McMillan, 2007).
- Trial name
- microRNAITP (NCT05371743)
- Testing
- Plasma RNA isolation, qPCR analysis of micro RNA, estimation of serum level of IL2, estimation of serum level of IL17
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sohag University
Tooth Extraction Status Nos
MicroRNA and MicroRNA Inhibitors Socket Study, Pilot Clinical Trial
To evaluate the efficacy of locally delivering plasmid DNAs encoding microRNAs, and/or microRNA inhibitors, in the promotion of osteogenesis and modulation of the inflammatory response on the basis of different clinical…
- Trial name
- NCT02579187
- Testing
- tooth extraction, CBCT scan, Anesthesia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gustavo Avila-Ortiz DDS, MS, PhD
Aortic Aneurysm
Blood microRNA Depression Change After DHCA
Collect the blood sample per-operation experience deep hypothermia cardiac arrest for aorta artery replacement surgery Collect the blood from the CPB machine and from intravenous injection tube which already set at different time…
- Trial name
- NCT03339414
- Testing
- collect blood
- Where
- China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- China International Neuroscience Institution
Orthodontic Tooth Movement
Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement
A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following…
- Trial name
- NCT06023433
- Testing
- Elastomeric powerchain
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Catania
Lung Neoplasm, Squamous Cell Carcinoma
Serum Exosomal miRNA Predicting the Therapeutic Efficiency in Lung Squamous Carcinoma
This is an observational prospective bi-center study of 50 patients operated on advanced squamous cell carcinoma. The main aim is to investigate the efficacy of serum exosomal miRNA as a biomarker for predicting the therapeutic…
- Conditions
- Lung Neoplasm, Squamous Cell Carcinoma, Exosomes
- Trial name
- NCT05854030
- Testing
- collect plasma samples and clinical features
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation (HSCT)
Clinical Performance of SE-SPTM-PCR in Detecting Hcmv-miR-UL22A-5p After Hematopoietic Stem Cell Transplantation
This study aims to evaluate the clinical performance of a novel microRNA-based detection platform, SE-SPTM-PCR, for identifying cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (HSCT).
- Conditions
- Cytomegalovirus Infections, Hematopoietic Stem Cell Transplantation (HSCT), CMV Reactivation, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- SESPTM-CMV (NCT07181330)
- Testing
- SE-SPTM-PCR microRNA assay
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ting YANG
Muscular Dystrophies, Becker Muscular Dystrophy
Evaluation of Muscle miRNA as Biomarkers in Dystrophinopathies
Duchenne muscular dystrophy (DMD) , caused by mutations in the DMD gene, is the most common and most severe progressive dystrophy of the child.
- Conditions
- Muscular Dystrophies, Becker Muscular Dystrophy, Duchenne Muscular Dystrophy
- Trial name
- biodystromirs (NCT02109692)
- Testing
- blood sample
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Intrahepatic Cholangiocarcinoma (Icc)
An Exosomal miRNA-based Liquid Biopsy for ICC Detection
Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need.
- Trial name
- LUMIC (NCT07225452)
- Testing
- Small RNA sequencing, LUMIC assay
- Where
- United States
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
Cancer
AssesSment of Early-deteCtion basEd oN liquiD Biopsy in PANCEATIC Cancer (ASCEND-PANCREATIC)
ASCEND-PANCREATIC is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, circulating tumor DNA (ctDNA) mutation, serum protein markers…
- Trial name
- NCT05556603
- Where
- 3 sites in China
- Volunteers
- 7,062 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Sepsis
MiRNAs Evaluate the Prognosis of Sepsis
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression.
- Trial name
- METPS (NCT01207531)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Heart Failure, Cardiovascular Diseases
Heart Failure and Related Risk-factors After Preeclampsia
This study is a cross-sectional case-control study where classical as well as more innovative risk factors for CVD will be explored.
- Conditions
- Heart Failure, Cardiovascular Diseases, Pre-Eclampsia
- Trial name
- QoH (NCT02347540)
- Where
- Netherlands
- Volunteers
- 2,580 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Food Addiction, Sexual Addiction
Physiopathology of Behavioral Addictions and Biomarkers
The goal of this observational study is to evaluate the expression of miR-10a-5p in the blood in patients with sexual addiction or food addiction.
- Trial name
- MiRACle (NCT07830680)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
This study will look at the blood and cerebrospinal fluid of consented participants who either have early stage multiple sclerosis (clinically isolated syndrome) or who have later stage (secondary progressive multiple sclerosis)…
- Conditions
- Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Clinically Isolated Syndrome
- Trial name
- NCT01737372
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- John F. Foley, MD
Diabetes Mellitus, Type 2
Rice Intervention in Chronic Health Study
The goal of this clinical trial is to learn if the low glycemic index (GI), polyphenol-rich red pigmented rice (UKMRC9) works to improve cardio-metabolic parameters in Malaysian adults with type 2 diabetes (T2D) and healthy…
- Trial name
- RICH (NCT06560541)
- Testing
- UKMRC9, White rice
- Where
- 10 sites in Malaysia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Taylor's University
Major Depressive Disorder, Suicidal Ideas
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future.
- Conditions
- Major Depressive Disorder, Suicidal Ideas, Suicide, Attempted, MDD
- Trial name
- NCT05437588
- Testing
- Genetic testing
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pregnant Women
microRNA Profile in Umbilical Cord Blood NK Cells
Umbilical cords contain immature blood cells, including a group of lymphocytes, that are important in the so-called natural immunity.
- Trial name
- NCT00751569
- Testing
- blood donation
- Where
- Taiwan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Plasma microRNA in Patients With Genetic Susceptibility to Mental Disorders
Study on the Difference of Plasma microRNA Expression in Patients With Genetic Susceptibility to Mental Disorders
Schizophrenia (Schizophrenia,Sc), biphasic affective disorder (Bipolar disorder,BPD), major depression (major depressive disorder,MDD), anxiety disorder (Anxiety disorder,An) and other mental disorders have obvious family…
- Trial name
- NCT03999931
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine