Clinical trials: microRNA
Hepatitis C
Safety Study of SPC3649 in Healthy Men
A placebo-controlled, double-blind, randomized, single dose, dose escalating trial in healthy men to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SPC3649.
- Trial name
- NCT00688012
- Testing
- SPC3649
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Santaris Pharma A/S
Muscle Function
Muscle in Obesity: Imaging, Function and microRNA
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither phenotype.
- Trial name
- NCT04300504
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Multiple Sclerosis
Immune Regulation in Multiple Sclerosis: The Effect of Glatiramer Acetate on MicroRNA Expression in Antigen-Presenting Cells
MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and glatiramer…
- Trial name
- NCT01993004
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Gestational Diabetes
miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction
The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.
- Trial name
- NCT05632055
- Testing
- blood draw
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
TBI (Traumatic Brain Injury), Brain Concussion
Dual-Task Exercise for Mild Traumatic Brain Injury (mTBI)
The investigators previously developed a virtual 14-day dual-task walking exercise program and tested its feasibility with individuals with mild traumatic brain injury (mTBI) history.
- Conditions
- TBI (Traumatic Brain Injury), Brain Concussion, Clinical Trial, Rehabilitation
- Trial name
- NCT06037603
- Testing
- Brain & Walk Exercise Every Day (BraW-Day)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
T Lymphocyte Disorder
MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis
Sepsis is a systemic inflammatory reaction caused by infection, trauma, etc. In the process of sepsis, the apoptosis of lymphocyte serves as a vital factor of immune dysfunction.
- Trial name
- NCT02756559
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lixin Xie
Melanoma
MicroRNA Expression and Function in Cutaneous Malignant Melanoma
Spectrophotometric intracutaneous analysis (SIAscopy) is a new technique for imaging pigmented skin lesions and for diagnosing melanoma and non-melanoma skin cancer.
- Trial name
- NCT00536029
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Diseases, Periodontal Diseases
Impact of Periodontal Treatment on Local miRNA Expression
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA…
- Trial name
- NCT05275127
- Testing
- changes of gingival crevicular fluid miRNA
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Catania
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
PANS, Pediatric Acute-Onset Neuropsychiatric Syndrome
Biomarkers for Diagnosis and Treatment Response in Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a complex neuropsychiatric disorder characterized by the abrupt onset of symptoms and currently diagnosed mainly on clinical criteria, as reliable diagnostic biomarkers…
- Trial name
- BIOMA-PANS (NCT07718958)
- Testing
- Psycodiagnostic evaluation, Polysomnography, 1H-NMR analysis
- Where
- 5 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Concussion, Mild
Predicting Concussion Outcomes With Salivary miRNA
The purpose of this study is to identify changes in salivary ribosomal nucleic acid (RNA) expression that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
- Trial name
- NCT02901821
- Testing
- salivary RNA collection
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Breast Cancer
Oncoliq: Test for Early Breast Cancer Detection.
Oncoliq is a novel early breast cancer detection test based on liquid biopsies and microRNAs. This innovative test will allow improving the accuracy of cancer detection which will impact on health, reducing the patient mortality…
- Trial name
- NCT04906330
- Testing
- Oncoliq: test for early breast cancer detection.
- Where
- Argentina
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Diabetes, Exercise
Differential Regulation of miRNA and Protein in Human Plasma Extracellular Vesicles by Different Types of Exercise.
Aims/hypothesis: Both continuous aerobic training (CAT) and high intensity interval training (HIIT) are recommended to promote health and prevent diseases.
- Conditions
- Diabetes, Exercise, Lifestyle Intervention
- Trial name
- NCT06609785
- Testing
- Exercise
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Smoking, Smoking Cessation
Smoking Cessation on the Human Airway: Mucus Secretion, Inflammatory and Proteomic Profile in Nose and miRNAs in Blood
Smoking cessation improves health conditions with reduction of the risk factors for cardiovascular and respiratory disease, as functional capacity and quality of life.
- Trial name
- NCT02136550
- Testing
- Smoking cessation
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Multiple Sclerosis, miRNA
miRNA Biomarkers in Multiple Sclerosis
Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS).
- Conditions
- Multiple Sclerosis, miRNA, Epigenetic, Biomarker
- Trial name
- NCT04772495
- Testing
- miRNA
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Infertility, Male
Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Men are recruited to collect seminal plasma samples and serum samples from men with azoospermia, men receiving medical treatment of infertility and men attending semen analysis.
- Trial name
- SemiFluid (NCT02932865)
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Rh Disease
Circulating microRNAs as Novel Prognosis Biomarkers for Rheumatoid Arthritis
The correlation of circulating serum miR-125ba and miR-146a expression and clinical response to green tea therapy were analysed in RA patients.Clinical response to green tea therapy for 24 weeks was calculated from DAS28 scores.
- Trial name
- NCT03719469
- Testing
- Green tea group
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King Saud University
Asthma, COPD
Circulating Micro RNAs Expression in Egyptian Bronchial Asthma and COPD Patients
This cross sectional study will be carried out on 30 subjects who will be recruited from the outpatient clinic of Chest Department, Tanta University Hospital.
- Trial name
- NCT02719145
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University