Clinical trials: microRNA
Reactive Hyperemia, Micro RNA
Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training
Epidemiological studies based on Danish registries have observed that Danish male firefighters have more cardiovascular disease, infertility diagnose and a trend to increased risk of cancer than other Danish employed males.
- Conditions
- Reactive Hyperemia, Micro RNA, Heart Rate Variability, DNA Strand Breaks
- Trial name
- BIOBRAND3 (NCT05753254)
- Testing
- Firefighting training exercises with no fire, Firefighting training exercises under wood fire, Firefighting training exercises under gas fire
- Where
- 2 sites in Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Osteoarthritis
Identification of miRNAs Associated With Gender Difference in Osteoarthritis Patients
The biological study involves the collection of samples from male and female patients (intraoperative waste tissue, blood and synovial fluid), suffering from mild and moderate-severe OA, who undergo endo or arthro-prosthesis…
- Trial name
- MIRGOA (NCT04851210)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Ortopedico Rizzoli
GLUCOSE METABOLISM, DIABETES
Investigating Predictive Factors of Diabetes Occurence After Duodenalpancreatectomy
Regeneration of mature cells that produce functional insulin represents a major focus of current diabetes research aimed at restoring beta cell mass in patients with most forms of diabetes.
- Conditions
- GLUCOSE METABOLISM, DIABETES, PANCREATIC ISLETS, Exocrine Pancreatic Dysfunction
- Trial name
- NCT02175459
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease
The aim of the prospective randomized single center study is to evaluate the effect of a short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease (CVD) risk factors in patients with CVD.
- Trial name
- SLYM II (NCT05250310)
- Testing
- Chair Yoga
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
HIV Infection, Tuberculosis Infection
Micro RNA as Prediction and/or Prognostic Markers of IRIS in TB-HIV Co-infected Patients
The role of miRNAs in HIV disease is yet to be completely defined. Host miRNAs target certain HIV genes, thus can affect HIV replication and participate in viral control.
- Trial name
- miRNA (NCT03941210)
- Testing
- Detection of molecular Biomarkers
- Where
- Cambodia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Brain Tumors
Establishment of a Signature of Circulating microRNA as a Tool to Aid Diagnosis of Primary Brain Tumors in Adults
MIRNA is a prospective multi-center observational study designed to explore 762 plasma microRNAs in patients with malignant CNS tumours: 60 primary glioblastoma (GBM), 20 primary CNS lymphomas and 40 brain metastases in an…
- Trial name
- MIRNA (NCT03630861)
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
MicroRNAs: D13.444.735.790.552.500
miRNA as a Growth Plate Marker After GH
The therapeutic use of recombinant human growth hormone usually determines adequate growth response in the majority of approved conditions.
- Trial name
- NCT05946915
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
B-cell Acute Lymphoblastic Leukemia
Evaluation of ProALL miRs in Blood Specimen for Prediction of ALL Relapse Risk
Previous findings have shown that a biomarker comprised of the three microRNAs (miRs) miR-451, miR-151-5p and miR-1290 can independently predict precursor B-cell acute lymphoblastic leukemia (B- ALL) patients' risk for relapse…
- Trial name
- NCT03000335
- Where
- 2 sites in Israel
- Volunteers
- 65 people
- Sponsor
- Curewize Health Ltd.
Crohn's Disease, Ulcerative Colitis
Specific microRNAs as Potential Biomarker for Inflammatory Bowel Disease
The aim of this study is to assess the ability of miR-320a and other specific microRNAs to follow the disease course in patients with Crohn's disease (CD) and ulcerative colitis (UC), and to distinguish both entities, infectious…
- Trial name
- NCT03698500
- Testing
- Removal of blood
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- University Hospital Muenster
Colorectal Cancer
Validation of a microRNA-based Fecal (miRFec) Test for Colorectal Cancer Screening, Surveillance and Diagnosis
The present study aims to compare effectiveness and cost-effectiveness of the miRFec test with respect to fecal immunochemical test (FIT) for the detection of advanced colorectal neoplasm among individuals participating in…
- Trial name
- miRFec (NCT05346757)
- Testing
- miRFec test
- Where
- Spain
- Volunteers
- 5,390 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cerebral Hemorrhage
Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral bleeding also known as spontaneous intracerebral hemorrhage (sICH) constitute 10-15 % of all apoplexies.
- Trial name
- NCT02326571
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Christian Kærsmose Friberg
Obesity, Morbid, Metabolic Syndrome
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Variable outcomes after weight loss surgery are likely attributable to complex, poorly understood mechanisms. Due to the significant impact that morbid obesity has on a patient's health, successful management of obesity and its…
- Conditions
- Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT04841057
- Testing
- 50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Non-Alcoholic Fatty Liver Disease
Micro RNA Levels in NAFLD
Epidemiological study of NAFLD, NASH patients. Descriptions of altered miRNA profiles in NAFLD patients especially with fibrosis.
- Trial name
- NCT04574557
- Testing
- micro RNA
- Volunteers
- 80 people
- Sponsor
- Assiut University
Preterm Birth, Pregnancy
Hippo-YAP Pathway and Related miRNAs in Preterm Birth
This completed observational study evaluated the expression of Hippo-YAP pathway-related genes and proteins and selected microRNAs in maternal blood, placental tissue, and myometrial tissue obtained from women who underwent…
- Conditions
- Preterm Birth, Pregnancy, Preterm Labor
- Trial name
- HIPPO-PTB (NCT07695467)
- Testing
- Laboratory Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Cumhuriyet University
Insulin Resistance
Effect of Dietary Protein on the Regulation of Exosome microRNA Expression in Patients With Insulin Resistance.
miRNAs are small non-coding RNAs of approximately 22 nucleotides in length, which have the function of regulating gene expression at the post-transcriptional level through base complementation of protein-coding transcripts, this…
- Trial name
- NCT05318898
- Testing
- Vegetal protein, Animal protein
- Where
- 2 sites in Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Chronic Idiopathic Urticaria
Three-month, Single-center Study to Identify Biomarkers/Response to Xolair Therapy in Chronic Idiopathic Urticaria
This is a single center, non-comparative exploratory study, to investigate the effect of omalizumab over a 3-month treatment period in adult (≥18 years) patients with chronic idiopathic urticaria who had remained symptomatic…
- Trial name
- NCT02814630
- Testing
- Xolair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Asthma Inc Clinical Research Center
Nephropathy, Opportunistic Viral Infection
Study of the Serotype and Genotype of BK Virus in Kidney Transplant Recipients and Their Donors to Identify Individuals at Risk of Nephropathy
The aim of this observational study is to characterize the urinary replication of BK polyomavirus (BKV) in kidney transplant recipients.
- Conditions
- Nephropathy, Opportunistic Viral Infection, Polyoma Virus Nephropathy, BK Nephropathy
- Trial name
- TYPIK (NCT07347769)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Adrenocortical Carcinoma
Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01528956
- Testing
- DNA methylation analysis, RNA analysis, gene expression analysis
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
microRNA, Circulating Tumor Cells
The Difference of microRNA and Circulating Tumor Cells in Blood Among Cancer Patients With Immunotherapy
Among the currently important biomarkers, circulating tumor cells and microRNA (miRNA) have received significant attention. The latter, also translated as micro-ribonucleic acid, is a widely present ribonucleic acid (RNA)…
- Conditions
- microRNA, Circulating Tumor Cells, Immunotherapy
- Trial name
- NCT07260370
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment
Protein and microRNA Markers for Early Detection of Alzheimer's Disease
Blood will be harvested from three groups of people, normal control, patients with mild cognitive impairment (MCI) and patients with Alzheimer's disease (AD), 20 people per group.
- Trial name
- NCT03388242
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sun Yat-sen University