Clinical trials: multiple sclerosis
Spasticity
A Prospective Study of Spasticity in Individuals With Multiple Sclerosis
This study is expected to contribute to the body of knowledge on the benefits of individuals with MS taking glatiramer acetate (Copaxone®).
- Trial name
- NCT01111435
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Fraser, Cira, Ph.D., RN, ACNS-BC
Multiple Sclerosis
Sensory Integration Disorders in Patients With MS Including Disease Advancement and Relapses in the Last Year
the aim of the study was to assess the occurrence of sensory integration disorders in people with SI depending on the stage of the disease and relapses in the last year;analysis of sensory integration disorders in patients with…
- Trial name
- NCT05449574
- Testing
- Scale for the Assessment of Sensory Integration in Adults
- Where
- Poland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Multiple Sclerosis
Applications of Nanotechnology in Multiple Sclerosis by Respiratory Samples
Multiple Sclerosis (MS) is a complex multi-factorial disease, with underlying both genetic and environmental factors. Different populations have different susceptibility.
- Trial name
- MS-NANOSE (NCT01206023)
- Testing
- NA-NOSE artificial olfactory system
- Where
- 2 sites in Israel
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis
Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders
The goal of this study is to use ultra-high-resolution (UHR) PET imaging to better understand how the brain and spinal cord change in healthy aging and in neurological and psychiatric disorders such as Alzheimer's disease (AD)…
- Conditions
- Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT07509125
- Testing
- UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain with ¹⁸F-SynVesT-1
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multiple Sclerosis
Gene Expression Profiles in Multiple Sclerosis (MS)
The purpose of this study is to test differences in RNA levels between Multiple Sclerosis (MS) patients and normal subjects. RNA provides a "message" from genes altered in diseases.
- Trial name
- NCT00704834
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Multiple Sclerosis
Study of Social Cognition by Morphological and Functional Imaging in Multiple Sclerosis Patients
In recent years, studies have brought knowledge of the difficulties of social cognition in Multiple Sclerosis (MS). The brain tissue alteration at the origin of these difficulties in social cognition mechanisms remain poorly…
- Trial name
- SOCOG-MS (NCT02290587)
- Testing
- Brain MRI - Clinical and cognitive evaluation, MRI
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Effect of Tysabri in Patients With Relapsing-Remitting Multiple Sclerosis: A Follow-up Magnetization Transfer Imaging (MTI) Study
The primary objective of this study is to define the effect of Tysabri in patients with relapsing-remitting (RR) multiple sclerosis (MS) over 2 years.
- Trial name
- NCT00937677
- Testing
- Tysabri
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Multiple Sclerosis
Allocentric Memory in MS and Resting State Functional MRI
The goals of this study are to 1. Investigate the sensitivity of allocentric visual memory when compared to more established measures of cognition in identifying cognitive difficulties among MS subjects when compared to controls.
- Trial name
- NCT02118298
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Sclerosis, Aquatic
Changes in Speed, Endurance and Balance in Women Patients With Multiple Sclerosis After 4 & 8 Weeks of Aquatic Exercise Training
Background: It has been shown that adults with Multiple sclerosis (MS) have less leg strength than their peers, as well as impaired balance, which has led to an increased prevalence of falls in this population.The purpose of this…
- Conditions
- Multiple Sclerosis, Aquatic, Exercise
- Trial name
- NCT02882724
- Testing
- Exercise, Control
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Isfahan
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Multiple Sclerosis
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
The investigators want to evaluate ovarian reserve concerning patients with multiple sclerosis, compared to a control group of healthy women. This study will include women from 25 to 35 years old.
- Trial name
- FEMINISEP (NCT05754593)
- Testing
- Anti-Mullerian hormone (AMH) level, Antral follicle count (AFC), Clinical assessment
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis
Imaging Multiple Sclerosis Lesions Using Magnevist and Gadavist
The investigators are conducting a magnetic resonance imaging (MRI) study comparing two MRI contrast agents in people with clinically isolated syndrome and relapsing remitting multiple sclerosis (MS).
- Trial name
- NCT01836055
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Multiple Sclerosis
Digitalization of Neurofunctional Tests Via a Mobile Application DAMS for Multiple Sclerosis Patients
Multiple Sclerosis (MS) is a chronic immune-mediated inflammatory disease with a broad diversity of symptoms and fluctuating progression patterns. Clinical assessments are challenging and are continually reviewed and enhanced.
- Trial name
- MSCopilot (NCT03148938)
- Testing
- Digital Assessment on mobile
- Where
- 10 sites in France
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Ad scientiam
Multiple Sclerosis
Single Ascending Doses Study With GNbAC1 in Healthy Male Volunteers
This is a phase I, double-blind, placebo controlled, parallel group, dose-escalating, randomised study designed to assess and compare the safety and tolerability, PK, and immunogenicity of GNbAC1 administered as a single dose at…
- Trial name
- NCT03574428
- Testing
- GNbAC1
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GeNeuro Australia PTY Ltd
Cognition, Brain Volume Loss
Effect of Fingolimod on Neurodegeneration
This was a 24-month, open-label, multicenter study with a single treatment arm design. Primary objective of this study was: -To investigate the effects of Fingolimod on cognitive performance in highly active relapsing remitting…
- Trial name
- NCT02575365
- Testing
- 0,5 mg Fingolimod
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis (MS), Fatigue
Increasing Physical Activity for Adults With Multiple Sclerosis (MS)
This study aims to advance the scientific understanding and potential future implementation of physical activity promotion by testing the efficacy of a phone-based app for increasing activity in insufficiently active patients…
- Conditions
- Multiple Sclerosis (MS), Fatigue, Physical Inactivity
- Trial name
- NCT06270641
- Testing
- ExerciseRx intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Washington
Central Nervous System (CNS) Demyelinating Disease, Multiple Sclerosis
Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants
The primary objective of this study is to assess the safety and tolerability of a single dose and multiple doses of BIIB033 administered to healthy adult Japanese participants.
- Trial name
- NCT02641041
- Testing
- BIIB033
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biogen
Multiple Sclerosis
Does Long-Term Natalizumab (NTZ) Therapy Normalize Brain Atrophy Rates and Quality of Life (QOL) in Relapsing Remitting Multiple Sclerosis (RRMS)?
Primary Aims: To determine how effective long term Natalizumab (NTZ) therapy is in slowing the progression of whole brain atrophy.
- Trial name
- NCT02588053
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis
Efficacy of tDCS on Pain in Multiple Sclerosis
Pain is a common symptom experienced by people with MS and can significantly interfere with participation in the activities of daily living and adversely affect health-related quality of life.
- Trial name
- NCT03389217
- Testing
- Real-tDCS + rehabilitation programme
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Multiple Sclerosis, Cognitive Decline
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Trial name
- MSNEUROPLAST (NCT04806568)
- Testing
- Cognitive Training, Monitoring of daily activity
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki