Clinical trials: multiple sclerosis
Multiple Sclerosis
Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis
Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.
- Trial name
- NCT05391906
- Testing
- Diffusion-weighted magnetic resonance imaging
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Multiple Sclerosis
Entire-body PET Scans for Multiple Sclerosis
To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
- Trial name
- EPSMS (NCT04390009)
- Testing
- Entire-body PET-CT scans, Amyvid radiopharmaceutical
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brain Health Alliance
Multiple Sclerosis
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and…
- Trial name
- NCT04699747
- Testing
- F-18 3F4AP
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Amyotrophic Lateral Sclerosis, Multiple Sclerosis
Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation
Neurodegenerative diseases are debilitating conditions characterized by chronic inflammation, leading to dysfunction of both the non-neuronal cellular components of the central nervous system and peripheral blood immune cells.
- Trial name
- CONTRASTOME (NCT06551649)
- Testing
- Venous blood draw and skin biopsy
- Where
- 2 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Amyotrophic Lateral Sclerosis (Healthy Volunteers)
Single & Multiple Ascending Dose Study of SAR443820 in Healthy Adult Participants
This is a Phase 1, single-center study conducted in 2 parts: Part 1a, single ascending dose (SAD-TDU16519): Double-blind, randomized, placebo-controlled sequential ascending single oral doses including up to 6 cohorts.
- Trial name
- NCT05795907
- Testing
- SAR443820
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis, Depressive Disorder, Major
Depression and Immune Function in Multiple Sclerosis (MS)
Depression is one of the most common symptoms of multiple sclerosis (MS) with a life-time prevalence of major depressive disorder (MDD) of up to 50%.
- Trial name
- DENIM (NCT02740296)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis, Relapsing-Remitting, Optic Neuritis
Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis
Multiple sclerosis (MS) affects approximately 2.3 million patients worldwide, with a global median prevalence of 33 per 100,000. MS is diagnosed at an average of 30 years and affects twice as many women as men.
- Trial name
- NCT03401879
- Testing
- Dynamic Vessel Analyzer (DVA), Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Optical coherence tomography (OCT)
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Multiple Sclerosis, Immune System Diseases
Mechanism of Action of Ocrelizumab in Multiple Sclerosis
Ocrelizumab is FDA approved for therapy of multiple sclerosis (MS). It depletes B cells and stops MS inflammation.
- Trial name
- NCT03344094
- Testing
- ocrelizumab
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Multiple Sclerosis
Effects of Reiki and Self-Acupressure Applications
Reiki, the subject of our research, is a complementary medicine practice within energy approaches. Discovered in Sanskrit texts by Dr.
- Trial name
- NCT07083856
- Testing
- Reiki, Self-Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Firat University
Multiple Sclerosis, Mitochondrial Alteration
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients.
- Trial name
- MS-MIDY (NCT03052595)
- Testing
- Oral glucose tolerance test, Testing of autonomous nervous system function, Stroop test
- Where
- Slovakia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Multiple Sclerosis
Novel Nanosensor Array for Detection of Volatile Biomarkers From Skin in Multiple Sclerosis
Multiple Sclerosis (MS) is the most common chronic neurological disease affecting young adults, with onset usually at the age 20-40 years.
- Trial name
- Nano-Skin-MS (NCT04074629)
- Testing
- Diagnosis, skin volatile organic compounds (VOCs)
- Where
- Israel
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
NMO Spectrum Disorder, MRI
Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases.
- Conditions
- NMO Spectrum Disorder, MRI, Multiple Sclerosis, MOGAD
- Trial name
- NCT04106830
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Multiple Sclerosis
Gilenya's Impact on Cognitive Function and Thalamic Volumes
This evaluation will be a one-year feasibility study to characterize the neuroprotective benefits of Gilenya and its effects on cognition and grey matter volumes.
- Trial name
- NCT03243721
- Testing
- 7T MRI, Neurocognitive testing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Physical Therapy, Upper Extremity Function
Upper Extremity Function, Shoulder Position Sense and Disability Level İn Patients With Multiple Sclerosis
The purposes of this study is to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis (MS) and which best projects the disability status.
- Conditions
- Physical Therapy, Upper Extremity Function, Position Sense
- Trial name
- NCT03846336
- Testing
- Upper extremity function, Shoulder position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Multiple Sclerosis
DreaMS - Digital Biomarkers for Multiple Sclerosis
The Investigators have developed the dreaMS App, a data communication platform collecting data from the patients' mobile devices (smartphone and wearables).
- Trial name
- DreaMS (NCT04413032)
- Testing
- DreaMS
- Where
- Switzerland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Research Center for Clinical Neuroimmunology and Neuroscience Basel
Neurological Disorder, Multiple Sclerosis
Metaverse Applications in Clinical Neurorehabiliation: Device Feasibility
The main objective of the TERSICORE project is the development of a new advanced set of exergames in the Metaverse that can be used in all clinical and home rehabilitation devices to improve the cognitive therapy of neurological…
- Conditions
- Neurological Disorder, Multiple Sclerosis, Parkinson Disease, Stroke
- Trial name
- TERSICORE XRM (NCT07456475)
- Testing
- Cognitive rehabilitation with TERSICORE digital platform
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Multiple Sclerosis
Effect of Tysabri in Patients With Relapsing-Remitting Multiple Sclerosis: A Follow-up Magnetization Transfer Imaging (MTI) Study
The primary objective of this study is to define the effect of Tysabri in patients with relapsing-remitting (RR) multiple sclerosis (MS) over 2 years.
- Trial name
- NCT00937677
- Testing
- Tysabri
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Balance Control
Quantified Balance Measures During Stance and Gait: Multiple Sclerosis Patients. A Longitudinal Clinical Study
The primary objective of this project is to track changes over time in balance control parameters measured during stance and gait for different groups of multiple sclerosis (MS) patients.
- Trial name
- MS-Gait (NCT02142946)
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland