Clinical trials: multiple sclerosis
Amyotrophic Lateral Sclerosis (ALS)
A Phase II Multi-centre, Extension Study to Investigate the Long Term Safety of ONO-2506PO in Patients Diagnosed With Amyotrophic Lateral Sclerosis (ALS)
The objective of this study is to investigate the long term safety of ALS patients taking ONO-2506PO.
- Trial name
- NCT00694941
- Testing
- ONO-2506PO
- Where
- 25 sites in Belgium, France and 5 more
- Volunteers
- 15 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Multiple Sclerosis
A Study to Evaluate the Pharmacokinetic Profiles of Single 14 mg Teriflunomide Tablet in Healthy Chinese Volunteers
Primary Objective: To assess the pharmacokinetic (PK) parameters of teriflunomide after a single oral dose of 14 mg administration in Chinese healthy subjects Secondary Objective: To assess the safety and tolerability after a…
- Trial name
- NCT02046629
- Testing
- Teriflunomide HMR1726, cholestyramine
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sanofi
Multiple Sclerosis
Resilience-Based Program for Support Partners of Persons With Multiple Sclerosis
This is a pilot feasibility study to examine the impact of providing a non-therapeutic resilience-based coaching telehealth program to the Support Partners (SP) of persons with MS (PwMS).
- Trial name
- NCT03555253
- Testing
- Resilience-Based Program for Support Partners of PwMS
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Healios Inc.
Multiple Sclerosis, Relapsing-Remitting
RItuximab Long-Term DOSE Trial in Multiple Sclerosis - RIDOSE-MS
A randomized trial of long-term dosage of rituximab in multiple sclerosis
- Trial name
- RIDOSE-MS (NCT03979456)
- Testing
- Rituximab
- Where
- 17 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis
Assessing the Induction of Long-term Immune Regulation Following Treatment With Lemtrada® (Alemtuzumab).
In this study the investigators wish to test the hypothesis that treatment with Lemtrada is associated with alterations in immune homeostasis in favor of multiple regulatory leukocyte populations which persist long after…
- Trial name
- NCT03647722
- Testing
- Assessment of leukocyte function.
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Southern California
Multiple Sclerosis
Be Cool: An Innovative and Holistic Psychoeducational Program for Multiple Sclerosis Individuals
This observational study aims to investigate the impact of an online psychoeducational program, combined with cooling therapy, nutrition, psychological intervention, and exercise, on the resilience, treatment adherence, symptom…
- Trial name
- BeCool (NCT06248281)
- Testing
- combination of different rehabilitation strategies
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Dietary Approaches to Treat Multiple Sclerosis-Related Fatigue Study
The purpose of this study is to compare the effect of the Swank Diet (low saturated fat) and the Wahls Elimination Diet (modified paleo) on fatigue levels in individuals with relapsing-remitting multiple sclerosis who have…
- Trial name
- Waves (NCT02914964)
- Testing
- Swank Diet, Wahls Elimination Diet
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Terry L. Wahls
Multiple Sclerosis
Role of Microglia in the Pathogenesis of Progressive Multiple Sclerosis
Our aim is to evaluate whether translocator binding protein (TSPO)-imaging correlates to Expanded Disability Status Scale (EDSS) and other disease progression-related clinical and paraclinical parameters in a homogenous cohort of…
- Trial name
- PROMS (NCT03134716)
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Multiple Sclerosis
A Positive Psychology Intervention for Patients With Multiple Sclerosis
Positive psychology (PP) uses targeted activities to increase the frequency and intensity of positive emotional experiences such as positive affect.
- Trial name
- NCT03637699
- Testing
- Positive Psychology
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI
This is the first comparison of efficacy of Betaseron and Copaxone for treatment of relapsing forms of MS.
- Trial name
- BECOME (NCT00176592)
- Testing
- Betaseron, Copaxone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Multiple Sclerosis
Study of Betaferon Adherence in Patients With Multiple Sclerosis Treated With Interferon Beta-1b
The primary objective of the study is to evaluate the adherence to the treatment with interferon beta-1b, in patients diagnosed with isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), or secondary progressive…
- Trial name
- ADHERENCE (NCT03408093)
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Volunteers
- 120 people
- Sponsor
- Bayer
Secondary Progressive Multiple Sclerosis (SPMS)
The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis
The goal of this clinical trial is to know if rituximab can improve cognitive and hand functions in secondary progressive multiple sclerosis (SPMS) patients with high disability (EDSS 6.5 or more).
- Trial name
- NCT06599307
- Testing
- Rituximab
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Multiple Sclerosis, Relapsing-Remitting
Measurement of Relaxin Peptide in Multiple Sclerosis (MS)
This study will evaluate relaxin (RLX) levels in patients with multiple sclerosis.
- Trial name
- NCT01909492
- Testing
- Blood Draw, Lumbar Puncture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Providence Health & Services
Multiple Sclerosis, Neuropathic Pain
A Study of Sativex in the Treatment of Central Neuropathic Pain Due to Multiple Sclerosis
To investigate the ability of Sativex to relieve central neuropathic pain in multiple sclerosis subjects.
- Trial name
- NCT01604265
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Jazz Pharmaceuticals
Multiple Sclerosis
EFFECTS OF AEROBIC AND RESISTANCE TRAINING ON IMMUNE FUNCTION IN MULTIPLE SCLEROSIS
Background: Multiple Sclerosis (MS) is a chronic immune-mediated, inflammatory, and neurodegenerative central nervous system disorder characterized by axonal damage.
- Trial name
- ABIF-MS (NCT07640100)
- Testing
- Aerobic and Progressive Resistance Exercise Program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Seda Saka
Multiple Sclerosis, Spasticity
One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity
Clinical protocol OS440-3003 is a multicenter, open-label, non-randomized, uncontrolled, dose escalation study to evaluate the safety and tolerability of Arbaclofen Extended Release Tablets over 1 year in Multiple Sclerosis (MS)…
- Trial name
- NCT01844232
- Testing
- arbaclofen
- Where
- 35 sites in United States, Russia and 1 more
- Volunteers
- 150 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Multiple Sclerosis
Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity
The study aimed to explore the link between urinary incontinence (UI) severity in patients with multiple sclerosis (PwMS), electromyography (EMG) findings, and other relevant factors.
- Trial name
- NCT07236684
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Artvin Coruh University
Clinically Isolated Syndrome, Multiple Sclerosis
Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion
This is a multicentric and prospective study for the validation of a diagnostic method in multiple sclerosis. Our hypothesis is that there is a characteristic profile of tears that can be recognized in order to help in the…
- Trial name
- POLAR (NCT02043964)
- Testing
- tears and cerebrospinal fluid sampling
- Where
- 15 sites in France
- Volunteers
- 165 people
- Sponsor
- Lille Catholic University
Multiple Sclerosis
The Role of Exercise in Modifying Outcomes for People With Multiple Sclerosis
Despite the benefits of exercise and physical activity people with Multiple Sclerosis (MS) are relatively inactive. Physical activity is important for persons with disabilities to maintain physical function.
- Trial name
- MStep (NCT01611987)
- Testing
- MStep, General guideline approach
- Where
- 5 sites in Canada
- Volunteers
- 240 people
- Sponsor
- McGill University
Multiple Sclerosis, Progressive Multiple Sclerosis
Effect of Variance on Error Correction During Coupling
This study is a case-control study, involving persons with progressive multiple sclerosis and healthy controls. The study contains 1 descriptive and 3 experimental sessions.
- Trial name
- NCT04856384
- Testing
- synchronisation abilities
- Where
- 2 sites in Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hasselt University
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