Clinical trials: on Invasive Mechanical Ventilation, active
Target Trial Emulation, Invasive Mechanical Ventilation
The Effect of NOn-invasive Respiratory Support on outcoMe and Its Risks in SARS-COV-2-related Hypoxemic Respiratory Failure
To determine whether early endotracheal intubation compared to late endotracheal intubation affects clinical outcome (duration of invasive mechanical ventilation, mortality).
- Trial name
- NORMO2 (NCT06757166)
- Testing
- endotracheal intubation
- Where
- Netherlands
- Volunteers
- 50,000 people
- Sponsor
- Erasmus Medical Center
Mucus Retention, Mechanical Ventilation Complication
Effects of Mechanical Insufflation-Exsufflation With Optimized Settings on Wet Mucus Volume During Invasive Ventilation
Retention of airway secretions is a frequent complication in critically ill patients requiring invasive mechanical ventilation (MV).This complication is often due to excessive secretion production and ineffective secretion…
- Trial name
- NCT06491017
- Testing
- MI-E Intervention protocol, Standard MI-E setting
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Resting Energy Expenditure, Indirect Calorimetry
Comparison of the Effects of SIMV-PC and SIMV-VC Ventilation Modes on Resting Energy Expenditure
The primary objective of this prospective observational study is to compare the effects of synchronized intermittent mandatory ventilation in pressure-controlled mode (SIMV-PC) and volume-controlled mode (SIMV-VC) on resting…
- Trial name
- NCT07790341
- Testing
- Volume-controlled ventilation, Pressure-controlled ventilation
- Volunteers
- 41 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Acute Respiratory Failure Requiring Intubation
A Study on the Assessment of Difficult Weaning in Patients With Acute Respiratory Failure Undergoing Mechanical Ventilation Based on Machine Learning EIT-pendelluft: A Multicenter Retrospective Study.
Invasive mechanical ventilation (IMV) is a common method used in the ICU to assist breathing and promote gas exchange. When a patient's condition improves, the weaning process (WP) should be initiated.
- Trial name
- NCT06756204
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Ruijin Hospital
Humidifier Lung, Mechanical Fragility
Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation
When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity.
- Conditions
- Humidifier Lung, Mechanical Fragility, Respiratory Complication
- Trial name
- FP950 (NCT06719258)
- Testing
- MR850, FP950
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Mechanical Ventilation
The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation
This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the…
- Trial name
- NCT07235956
- Testing
- Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.
- Volunteers
- 100 people
- Sponsor
- Zheng Qingjiang
Respiration Disorders
Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula
The primary goal of this study is to assess diaphragm function in patients with acute respiratory failure before and during the use of high-flow oxygen and/or non-invasive breathing support.
- Trial name
- DIAFUSION (NCT06892912)
- Testing
- Diaphragmatic ultrasound
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Foro Internacional en Cuidado Crítico
Invasive Mechanical Ventilation, Extubation Time
Measurement of Efferent Neural Drive From Respiratory Centers to Upper Airways Using Electromyography (EMG) of Genioglossus (GG) in Patients Dependent on Invasive Mechanical Ventilation
Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration.
- Trial name
- NCT07842484
- Testing
- electromyography (EMG) of genioglossus (GG)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Mechanical Ventilation
Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU
The NUTRIREA-4 trial will test the hypothesis that an individually tailored rehabilitation program combining nutritional therapy, physiotherapy, and physical activity and started early in the ICU then continued uninterruptedly…
- Trial name
- NUTRIREA-4 (NCT06581939)
- Testing
- Rehabilitation group, Control group
- Where
- 52 sites in France
- Volunteers
- 830 people
- Sponsor
- Nantes University Hospital
Chronic Heart Failure
Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study
The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures.
- Trial name
- HiFlow-Heart (NCT04471129)
- Testing
- HFO/O2C/NIV, NIV/O2C/HFO
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Pupillometry, Behavioral Pain Scale
Pupillometry vs. BPS (Behavioral Pain Scale) for Analgesia Management in Inpatient Intensive Care Unit Patients on Invasive Mechanical Ventilation
Patients admitted to the intensive care unit (ICU) and receiving invasive mechanical ventilation (IMV) frequently require sedation and analgesia to ensure their comfort, prevent pain associated with invasive procedures, and…
- Conditions
- Pupillometry, Behavioral Pain Scale, Analgesia Assessment, Intensive Care Unit (ICU)
- Trial name
- GOLDEN EYE (NCT07867678)
- Testing
- PPI Measurement (Pupillary Pain Index), BPS Measurement (Behavioral Pain Scale)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Non Invasive Ventilation (NIV)
Stress Ball Use in Non-Invasive Mechanical Ventilation Patients
Non-invasive mechanical ventilation is the first-line treatment for acute respiratory failure in patients with type II respiratory failure.
- Trial name
- NCT07752004
- Testing
- With stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
De Novo Hypoxemic Acute Respiratory Failure (hARF)
Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate.
- Trial name
- HighCPAP (NCT06213168)
- Testing
- HFNC, CPAP and HFNC
- Where
- 29 sites in France
- Volunteers
- 1,084 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation, Critical Illness
Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE)
This clinical study aims to compare the effects of conventional physical therapy alone versus conventional physical therapy combined with neuromuscular electrical stimulation (NMES) in patients admitted to the ICU and undergoing…
- Conditions
- Mechanical Ventilation, Critical Illness, Intensive Care Unit Patients, Muscle Weakness Condition
- Trial name
- MOVCARE (NCT07188350)
- Testing
- Conventional Physical Therapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital Moinhos de Vento
Weaning From Mechanical Ventilation, Tracheostomy Weaning
Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation
Rationale: Tracheostomized patients weaning from mechanical ventilation are at risk for dryness of airway mucosa and sputum accumulation during disconnection from mechanical ventilation.
- Conditions
- Weaning From Mechanical Ventilation, Tracheostomy Weaning, Respiratory Failure
- Trial name
- PIONEER (NCT06776939)
- Testing
- Oxygen therapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Henrik Endeman
Analgesia, ICU Patients Requiring Invasive Mechanical Ventilation
Clinical Study on the Efficacy and Safety of Hydromorphone for ICU Analgesia
This study is a prospective, single-center clinical study to evaluate the advantages, extensibility and safety of hydromorphone as an analgesic drug in ICU, and to compare it with remifentanil, a traditional sedative drug.
- Trial name
- NCT06848452
- Testing
- no-intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna