Clinical trials: pH Changes
Pregnancy Related, Dental Caries
The Effects of Pregnancy on Oral Health
The aim of this study was to evaluate the effects of pregnancy on salivary pH, flow rate, caries experience and periodontal status.
- Conditions
- Pregnancy Related, Dental Caries, Periodontal Diseases, Saliva Altered
- Trial name
- NCT06343337
- Testing
- Evaluation of DMFT index, CPI scores, salivary pH and flow rate in pregnant and non-pregnant woman
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of acidic and sweetened food and beverage is known to reduce the salivary pH and some of them reduce it to…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-C (NCT03526770)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Gastro-esophageal Reflux Disease (GERD)
Compound Sodium Alginate Oral Suspension Sachet 4-hour Esophageal pH Study in GERD Patients
Multi-centre, randomised, open-label, placebo-controlled, two-period crossover study of 4 hour pH monitoring following a refluxogenic meal and drink.
- Trial name
- NCT02619747
- Testing
- Compound Sodium Alginate Oral Suspension sachet
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Hypertension (World Health Organization Group 3)
Nailfold Capillaroscopy in PH
Pulmonary hypertension (PH) is an uncommon condition and can often be difficult to diagnose. It means elevated blood pressure in the lungs which can rapidly lead to failure of the right side of the heart and is ultimately fatal.
- Conditions
- Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH), Pulmonary Hypertension (World Health Organization Group 3), Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT07768644
- Testing
- Standard of Care therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Glasgow
Incontinence-associated Dermatitis
Reducing Skin Surface pH During Skin Occlusion: Changes to Skin Microbiome and Skin Parameters
The main aim of this exploratory research study is to investigate how exposure to a material with low pH affects the skin microbiome and skin parameters.
- Trial name
- NCT06363786
- Testing
- Test patches
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Essity Hygiene and Health AB
Oral Health
The Effect of Oral Sprays on Salivary pH
The aim of the study is to assess the effect of oral foams on salivary pH changes after Coca-cola consumption in young adults.
- Trial name
- NCT06148662
- Testing
- No intervention (negative control), Water (positive control), Dental foam "Biorepair PERIBIOMA"
- Where
- Russia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Gastroesophageal Reflux Disease
Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients
This study is being conducted to assess the effectiveness of the Compound Sodium Alginate Double Action Chewable Tablets compared to placebo on acidic reflux events into the esophagus in patients diagnosed with Gastroesophageal…
- Trial name
- NCT01872897
- Testing
- Sodium Alginate Double Action Chewable Tablets
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Healthy Subjects
The Effects of Urinary pH Changes on an Investigational Compound in Healthy Subjects
This study is designed to explore the effect of increased and decreased urinary pH on the single pharmacokinetic (PK) dose of LY2140023 and its active metabolite LY404039.
- Trial name
- NCT01440478
- Testing
- Ammonium Chloride + LY2140023, Sodium Bicarbonate + LY2140023, LY2140023
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Denovo Biopharma LLC
Streptococcus Mutans Count, Salivary pH
Clinical Performance, Streptococcus Mutans Count, and Salivary pH for Cention-N, Zirconomer, and Resin-modified Glass Ionomer in Class I Restoration of Primary Molars
This study will evaluate the clinical performance, Streptococcus mutans count, and salivary pH for Cention-N, Zirconomer, and resin-modified glass ionomer in Class I restoration of primary molars.
- Conditions
- Streptococcus Mutans Count, Salivary pH, Cention-N, Zirconomer
- Trial name
- NCT07776912
- Testing
- Cention-N, Zirconomer, Resin-Modified Glass Ionomer
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Galal Ali Mohamed Ebaid
Gastroscopy
Evaluation of Gastric Volume and pH Changes in Gastroscopy Patients
Pulmonary aspiration is a rare but serious complication that can result in 57% mortality and 14% permanent damage. Fasting rules (solid foods 6-8 hours, clear liquids 2 hours) determined by anesthesia associations are applied to…
- Trial name
- NCT06842602
- Testing
- gum, candy, strict fasting rules
- Where
- Turkey (Türkiye)
- Volunteers
- 405 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Dental Plaque, Saliva Altered
A Comparison Between Orthodontic and Non-orthodontic Patients on Oral Indexes and Salivary pH and Quality
This study aims to assess the caries susceptibility in pediatric patients aged 6-14 years old using Saliva-Check Buffer salivary tests. A total of 40 patients will be enrolled, divided into two groups: 1.
- Trial name
- NCT06922799
- Testing
- Saliva-Check Buffer test and periodontal charting
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Orthodontic Treatment, Saliva
Salivary Flow, pH, and Buffering Capacity in Fixed and Clear Aligner Orthodontic Treatment
Study Design: A randomized controlled trial with two parallel arms and an allocation ratio of 1:1. Setting: The study will be conducted in the orthodontic department of Riyadh Elm University hospitals in Riyadh City, Saudi…
- Trial name
- NCT07397871
- Testing
- Fixed orthodontic appliances, Clear Aligner Treatment
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Riyadh Elm University
Ph-negative Adult Acute Lymphoblastic Leukemia
Multicenter Clinical Trial for Adult Ph-negative ALL. Non-intensive But Non-iterruptive Treatment
1. evaluation of blast clearance in b/m after 7 days of prednisolone prephase and the efficacy of its substitution by dexamethasone if blast count is 25% and more 2.
- Trial name
- NCT01193933
- Testing
- autologous HSCT
- Where
- Russia
- Volunteers
- 321 people
- Sponsor
- National Research Center for Hematology, Russia
Leukemia, Lymphoblastic, Acute
"Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients
This study aims at considering clinical heterogeneity of patients based on a "geriatric assessment" without taking into account the real age of the subject.
- Trial name
- LAL1104 (NCT00475280)
- Testing
- Geriatric assessment adapted therapy, Stem cells autotransplantation
- Where
- 32 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Acute Lymphoblastic Leukemia, Adult B Lymphoblastic Lymphoma
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
This partially randomized phase III trial studies the side effects of different combinations of risk-adapted chemotherapy regimens and how well they work in treating younger patients with newly diagnosed standard-risk acute…
- Conditions
- Acute Lymphoblastic Leukemia, Adult B Lymphoblastic Lymphoma, Ann Arbor Stage I B Lymphoblastic Lymphoma, Ann Arbor Stage II B Lymphoblastic Lymphoma
- Trial name
- NCT01190930
- Testing
- Cyclophosphamide, Cytarabine, Dexamethasone
- Where
- 243 sites in United States, Australia and 5 more
- Volunteers
- 9,350 people
- Sponsor
- Children's Oncology Group
Smoking Behaviors
Effect of Oral pH Changes on Smoking Desire
Nicotine is a psychoactive substance and its effect is demonstrated by neuronal nicotinic-acetylcholine receptors excreted in the brain and periphery.
- Trial name
- NCT04032236
- Testing
- caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Leukaemia,Lymphoblastic
Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL
This prospective study was conducted to evaluate the efficacy and safety profiles of Modified MRCUKALLⅫ/ECOGE2993 Regimen in young adults with newly diagnosed, low-risk, Philadelphia chromosome negative acute lymphoblastic…
- Trial name
- NCT02660762
- Testing
- Vincristine, Daunorubicin, Pegaspargase
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Wound Healing Time, Total Hip Arthroplasty (THA)
Wound Healing, Dressing Type, and Dressing Change Frequency in THA
Surgical wound complications following primary total hip arthroplasty remain a significant clinical challenge despite advances in wound care technologies.
- Trial name
- CAP-HIP (NCT07655388)
- Testing
- VACUTEX™ wound dressing, Octenisept® wound care dressing
- Where
- Serbia
- Volunteers
- 90 people
- Sponsor
- Clinical Center of Vojvodina
Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension
Trial of Variable Dialysate Bicarbonate
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.
- Conditions
- Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension, Electrolyte Changes, pH Changes
- Trial name
- NCT05814146
- Testing
- Dialysate bicarbonate concentration, Dialysate bicarbonate concentration - telemetry monitoring
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Brigham and Women's Hospital
Saliva Altered, Plaque
Xylitol Chewable Tablets Versus Xylitol Chewing Gum in Geriatric Bedridden Patients
This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both…
- Trial name
- NCT03877705
- Testing
- Listerine ready tabs
- Where
- Egypt
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University