Clinical trials: psoriasis
Psoriasis, Plaque Psoriasis
A Study to Evaluate and Compare the Efficacy and Pharmacokinetics of MK-0873 for the Treatment of Plaque Psoriasis (MK-0873-022)
This is a within-participant comparison study to investigate the efficacy of a 28-day regimen of MK-0873 2% cream twice a day (b.i.d.) compared to MK-0873 vehicle (matching placebo) b.i.d.
- Trial name
- NCT01235728
- Testing
- MK-0873 2% Cream, Calcitriol Cream
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Merck Sharp & Dohme LLC
Plaque Psoriasis
Exploratory Study to Evaluate the Application of NLAC Cream in Adults With Plaque Psoriasis
Psoriasis is a chronic and immune mediated skin disorder that presents with plaques of thickened, scaly skin. Up to 71% patients suffer from psoriasis, leading to high impact on their daily life.
- Trial name
- NCT05078567
- Testing
- 5% Natural Lactic Acid-enriched Cream
- Volunteers
- 10 people
- Sponsor
- Microbio Co Ltd
Plaque Psoriasis
A Study to Evaluate Ustekinumab in Patients With Plaque Psoriasis in Asia-Pacific Countries
The purpose of this study is to determine how patients use ustekinumab (label-recommended or other/missed dose interval) in Asia-Pacific countries.
- Trial name
- MARCOPOLO (NCT01677598)
- Testing
- No intervention
- Where
- 9 sites in Indonesia, Malaysia and 3 more
- Volunteers
- 169 people
- Sponsor
- Janssen Research & Development, LLC
Psoriasis, Anti Mullerian Hormone
Ovarian Reserve in Patients With Psoriasis
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Autoimmune diseases including psoriasis are linked to premature ovarian reserve.
- Conditions
- Psoriasis, Anti Mullerian Hormone, Ovarian Reserve
- Trial name
- NCT03492632
- Testing
- Hormone panel
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Arrhytmia in Psoriasis
P Wave and QT Dispersion in Psoriasis
Background: Several reports have demonstrated an association between psoriasis and cardiovascular diseases. P wave dispersion (PWD) is the most important electrocardiographic (ECG) markers used to evaluate the risk of atrial…
- Trial name
- NCT02045485
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Psoriasis
Evaluation of Humira Retention Rate in Psoriasis Patients in Daily Practice and Assessment of Work Productivity and Quality of Life
This observational study will document to what extent in daily clinical practice Humira (adalimumab) therapy is continued, interrupted or permanently discontinued during a follow-up period of 2 years.
- Trial name
- NCT01169987
- Volunteers
- 191 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Psoriasis
Apremilast in Combination With Clobetasol Spray for the Treatment of Plaque Psoriasis
Researchers want to find out if giving the drug Apremilast in combination with Clobetasol spray can help people clear their moderate to severe plaque psoriasis quicker than if Apremilast is used by itself.
- Trial name
- NCT03453190
- Testing
- Apremilast and Clobetasol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington Dermatology Center
Chronic Plaque Psoriasis
ChangE From Any Systemic psoriasiS therapY to Raptiva
To assess the safety of transitioning subjects to Raptiva therapy from standard oral systemic or phototherapy by overlapping with Raptiva whilst tapering the initial systemic therapy or phototherapy dose.
- Trial name
- EASY (NCT00697593)
- Testing
- Efalizumab - anti CD11a recombinant human monoclonal antibody (mAb)
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Rheumatoid Arthritis, Psoriatic Arthritis
Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy
Systemic autoimmune and chronic inflammatory diseases are a group of chronic illnesses whose treatment is usually very prolonged, often lifelong, and is essential to keep the disease under control, thus reducing the risk of…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis
- Trial name
- TEMPLATE (NCT06544343)
- Testing
- Remote Monitoring, On site monitoring
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- University Of Perugia
Psoriasis
Study of Topical Calcitriol or Oral Calcitriol in Patients With Psoriasis
OBJECTIVES: I. Evaluate the long term safety and efficacy of orally administered calcitriol in patients with at least 5% of their body covered with psoriasis. II.
- Trial name
- NCT00004468
- Testing
- calcitriol
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Rheumatoid Arthritis, Psoriatic Arthritis
Yoga-mindfulness for Pain Management in Inflammatory Arthritis
This study evaluates the potential effects on pain, pain-related symptoms and quality of life of a yoga-mindfulness program, compared to patient education and physiotherapy, for patients with inflammatory arthritis and persistent…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Pain
- Trial name
- NCT04065958
- Testing
- Yoga-mindfulness, Patient education and physiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Psoriasis
CYA Versus MMF for Treatment of Moderate-Severe Psoriasis.
Psoriasis is an immuno-mediated skin disorder, which affects about 2-3% of the population worldwide. For moderate-severe forms of psoriasis systemic immunosuppression is the treatment of choice.
- Trial name
- NCT00295425
- Testing
- Cyclosporine A versus mycophenolate mofetil for psoriasis
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Muenster
Psoriasis Vulgaris
Anti-Inflammatory Effects of 0.045% Tazarotene/0.01% Halobetasol Lotion in Psoriasis
The objective of this research is to demonstrate superior anti-inflammatory effects, as demonstrated by a reduction in TNF-a and IL-17A, with tazarotene/halobetasol lotion in patients with mild to moderate plaque type psoriasis…
- Trial name
- NCT06042647
- Testing
- 0.01% Halobetasol, 0.045% Tazarotene, 0.05% Clobetasol Propionate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dermatology Consulting Services, PLLC
Psoriatic Arthritis
Safety and Effectiveness and Effect on Quality of Life and Work Productivity of Humira in Patients With Psoriatic Arthritis in Clinical Routine
Safety and effectiveness, quality of life and work productivity of Humira in patients with psoriatic arthritis in clinical routine.
- Trial name
- ELAN (NCT01078610)
- Testing
- adalimumab (Humira)
- Sponsor
- Abbott
Psoriasis
Narrow-Band UVB-Therapy in Psoriasis
Study on two different irradiation schemes in UVB phototherapy for psoriasis. Previous studies demonstrated a similar clinical effect in erythematogenic and suberythematogenic irradiation, with less complications in…
- Trial name
- NCT00748020
- Testing
- UVB phototherapy
- Where
- Netherlands
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Psoriatic Arthritis, Withdrawal
Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis
The rationale for this study is to investigate whether in psoriatic arthritis (PsA) patients in stable remission a reduction or complete discontinuation of immunosuppressive therapy can be achieved in a treat-to-target approach…
- Conditions
- Psoriatic Arthritis, Withdrawal, Reduction
- Trial name
- NCT04610476
- Testing
- Prednisolone, Sulfasalazine, Leflunomide
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Plaque Psoriasis, Metabolic Dysfunction-Associated Steatotic Liver Disease
A Study to Estimate Secukinumab Retention Rate in Psoriasis Patients With MASLD
This study aims to examine the retention rate of secukinumab in adult patients with plaque psoriasis (with or without psoriatic arthritis [PsA]) and metabolic dysfunction-associated steatotic liver disease (MASLD) in routine…
- Trial name
- SEC-HOPE (NCT07683065)
- Where
- 7 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Psoriasis
A Real-World Study on the Impact of Weight Loss on Treatment Efficacy in Overweight/Obese Patients With Plaque Psoriasis
The goal of this investigator-initiated, real-world, observational study is to investigate the impact of weight loss on treatment efficacy in overweight or obese Chinese patients with moderate-to-severe plaque psoriasis.
- Trial name
- NCT07382388
- Testing
- Weight loss and psoriasis treatment, psoriasis treatment
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Psoriasis
Hypertension, Antihypertensive Medication Use, and Risk of Psoriasis
The influences of hypertension and antihypertensive medication on psoriasis have been long discussed. Given the limited and inconsistent evidence available, there is a need to further explore and clarify the relationship between…
- Trial name
- NCT06075394
- Where
- China
- Volunteers
- 9,294 people
- Sponsor
- Xijing Hospital
Psoriasis
This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis
To assess the influence of risankizumab on kinetics of cytochrome P450 (CYP) probe drugs as a means of predicting drug-drug interactions.
- Trial name
- NCT02772601
- Testing
- Caffeine, Warfarin, Omeprazole
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- AbbVie
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