Clinical trials: stroke
Stroke, Rehabilitation
Extracellular Vesicles as Stroke Biomarkers
The combination of rehabilitation protocols and regenerative therapies offers the outstanding opportunity to promote and enhance the endogenous regenerative and repair processes occurring in tissues damaged or lost due to injury…
- Trial name
- EXO4STROKE (NCT05370105)
- Testing
- blood withdrawal
- Where
- 2 sites in Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Healthy
Neuromodulation and Language Acquisition (Stage Ib)
The purpose of this study is to determine whether rivastigmine or pramipexol are effective in boosting semantic language acquisition in healthy subjects.
- Trial name
- NCT00102856
- Testing
- Pramipexole, Rivastigmine
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Stroke
The Effect of Optic Flow Speed Manipulation and the Level of Immersion on the Gait Pattern in People Post-stroke
The aim of this study is to investigate the effect of manipulating the optic flow speed in the virtual environment on the gait pattern during virtual reality (VR) - enhanced treadmill walking in people post-stroke.
- Trial name
- NCT04521829
- Testing
- Walking with different optic flow speeds with 2 different VR devices
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Stroke, Healthy Older Adults
Comparative Efficacy of Two Different Dual-task Balance Interventions
The objective of this study is to investigate the effects of two different dual-task balance interventions for stroke patients and older adults.
- Trial name
- NCT03234998
- Testing
- motor-cognitive dual-task training, cognitive dual-task training
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Acute Ischemic Stroke
Prognostic Markers of Post-Stroke Depression (PROMoSD)
Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.
- Trial name
- PROMoSD (NCT05580198)
- Testing
- Transcranial sonography.
- Where
- Germany
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Acute Ischaemic Stroke, Depression
Screening of New Markers of Gut Microbiota in Stroke and Depression: a Cross-sectional Study
Objectives of Study： Through the cross-sectional study of stroke and depression, key biomarkers are targeted by screening disease-associated intestinal bacteria, metabolites and immune factors through multi-omics techniques.
- Trial name
- NCT06379464
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stroke, Acute, Educational Problems
Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge
This study is a single-center, randomized, open-label, controlled, endpoint-blinded study to assess the effect of off-script diagnosis \& differential diagnosis (D\&D) training in improving the residents' knowledge of acute…
- Conditions
- Stroke, Acute, Educational Problems, Clinical Course
- Trial name
- CAST-AIS (NCT06941753)
- Testing
- Off-script diagnosis & differential diagnosis (D&D) training
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Stroke
Deficit Fields for Stroke Recovery
This study investigates the potential of customized robotic and visual feedback interaction to improve recovery of movements in stroke survivors.
- Trial name
- NCT02570256
- Testing
- Deficit-fields to reduce error, Deficit-fields to expand range of motion, Deficit-fields to improve function
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Cardiovascular Diseases, Arrythmia
iPSC Biobank of Biomarkers Diversity in Cardiovascular Disease
The Investigators will create a clinical database and a Biobank of stem cells derived from the blood of participants with cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Arrythmia, Cardiomyopathies, Heart Failure
- Trial name
- INFERENCE (NCT06371937)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke
SMARTCap Stroke Study: A Field Deployable Blood Test for Stroke
The hypothesis is that a stroke causes release of purines from brain into blood and that this is a very early biomarker of brain ischaemia.
- Trial name
- SMARTCAP (NCT02308605)
- Testing
- SMARTCap
- Where
- 2 sites in United Kingdom
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Stroke, Motor Disorders
Direction Modulation of Muscle Synergies After a Stroke
The aim of the study is to investigate the capacity of post-stroke individual (study group) to modulate their EMG muscle activation pattern (MAP) compared to healthy individuals (control group), and to correlate these capacities…
- Trial name
- NCT03063151
- Testing
- Surface Electromyography (EMG)
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Neuro-Degenerative Disease
Synaptic Density, Tau and Multiparametric PET-MR in Brain Trauma, Stroke and Mild Cognitive or Behavioral Impairment.
Alzheimer's disease, stroke and TBI are frequently observed brain disorders, causing significant morbidity. For none of these disorders, there are in vivo diagnostic biomarkers available that allow determination of disease…
- Trial name
- NCT03514524
- Testing
- PET-MR imaging
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Back Pain
Characteristics of Back Pain Callers
Back pain is experienced by approximately 80% of the population during their life. However, only a small minority (<1%) will have a medical condition (such as Cauda Equina Syndrome) which requires immediate medical intervention.
- Trial name
- NCT03474068
- Volunteers
- 7,120 people, healthy volunteers welcome
- Sponsor
- Teesside University
Stroke
XNKQ Acupuncture Compared to Control Interventions Measured With EEG and fMRI
The investigators will use EEG, structural MRI, and resting-state functional connectivity MRI to assess neuronal responses in 28 healthy subjects to different somatosensory stimulations.
- Trial name
- NCT02453906
- Testing
- XNKQ, Control 1, Control 2
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Claudia M. Witt
Stroke, Depression
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
This study aims to pilot test an 8-week, self-administered dyadic (couples-based) positive psychology intervention for couples coping with stroke using a randomized, waitlist control design.
- Conditions
- Stroke, Depression, Depressive Symptoms, Post-stroke Depression
- Trial name
- RESToreD (NCT03335358)
- Testing
- Dyadic (couples-based) positive psychology intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Utah
Stroke
Pushing Spatiotemporal Limits for 4D Flow MRI and Dynamic MRA in the Brain at Ultra-High Field
This study aims at investigating the blood hemodynamics with high spatiotemporal resolution in patients with brain aneurysms and AVMs as well as in healthy controls.
- Trial name
- NCT02576743
- Testing
- 7 Tesla MRI
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cerebrovascular Accident
Anti-MAG First Administration to Human
GSK249320 is a monoclonal antibody directed against myelin associated glycoprotein (MAG), a protein that inhibits axonal regeneration.
- Trial name
- NCT00622609
- Testing
- GSK249320A
- Where
- 2 sites in United States, Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stroke
Protective Effects of Remote Limb Ischemic Preconditioning on Acute Cerebral Infarction
Stroke is one of the three leading causes of human death, and a major cause of adult disability. Our pre-clinical studies confirmed that ischemic preconditioning can prevent cerebral infarction.
- Trial name
- NCT01672515
- Testing
- RIPC group, Control group
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Capital Medical University