Clinical trials: stroke
Aphasia, Cerebrovascular Accident
Treating Intention In Aphasia: Neuroplastic Substrates
The purpose of this study is to determine if an "intentional act" improves treatment response for patients with nonfluent aphasia. The treatment involves naming pictures and saying members of categories.
- Trial name
- NCT00567242
- Testing
- Word-finding with intention component, Word-finding with no intention component
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Aphasia, Primary Progressive Aphasia
Circuitry Assessment and Reinforcement Training Effects on Recovery
This study investigates if electroencephalography (EEG) neurofeedback training is more beneficial than sham feedback training for the improvement of communication, anxiety, and sleep quality in individuals with aphasia.
- Conditions
- Aphasia, Primary Progressive Aphasia, Stroke
- Trial name
- CARTER (NCT04290988)
- Testing
- EEG Neurofeedback
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Atherosclerosis, Myocardial Ischemia
Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Particpants With Acute Coronary Syndrome (TRA•CER) (Study P04736)
The study is designed to determine whether vorapaxar, when added to the existing standard of care (eg, aspirin, clopidogrel) for preventing heart attack and stroke in patients with acute coronary syndrome, will yield additional…
- Conditions
- Atherosclerosis, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00527943
- Testing
- Vorapaxar
- Volunteers
- 12,944 people
- Sponsor
- Merck Sharp & Dohme LLC
Stroke, Inflammation
Inflammatory Abnormalities in Muscle After Stroke: Effects of Exercise
The purpose of this study is to first define whether abnormalities of skeletal muscle are related to the presence of inflammation and to poor motor performance and whether this can be modified by exercise interventions.
- Trial name
- NCT00387712
- Testing
- Velocity based treadmill training, Duration based treadmill training
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- VA Office of Research and Development
Stroke
Strength, Flexibility, And Balance Therapy After Stroke
Approximately 780,000 people suffer a stroke annually in the United States; 200,000 are recurrent strokes. The 17,000 veterans who suffer a stroke yearly are at great risk for a second stroke and therefore should be targeted for…
- Trial name
- HEALTHY (NCT01109602)
- Testing
- Yoga focused on strength, flexibility, and balance
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Stroke, Rhabdomyolysis
Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2
This trial will be a phase 2 randomized safety study in which ischemic stroke patients will be randomly assigned within 24 hours of symptom onset to placebo or standard dose lovastatin versus short-term high-dose lovastatin 640…
- Conditions
- Stroke, Rhabdomyolysis, Jaundice
- Trial name
- NeuSTART2 (NCT01976936)
- Testing
- Low Dose Lovastatin, High Dose Lovastatin
- Where
- 7 sites in United States
- Volunteers
- 162 people
- Sponsor
- Columbia University
Stroke, Obstructive Sleep Apnea
Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
There are two purposes of this study. The first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life.
- Trial name
- BOSAST (NCT00952211)
- Testing
- CPAP, CPAP at sub-therapeutic pressure
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Diego
Acute Ischemic Stroke
A Study to Evaluate the Safety and Potential Efficacy of LT3001 Drug Product in Subjects With AIS
This is a multicenter, double-blind, single-dose, randomized, and placebo-controlled prospective Phase IIa clinical study, designed to evaluate LT3001 drug product versus placebo/control in subjects with AIS.
- Trial name
- NCT04091945
- Testing
- LT3001 Drug Product
- Where
- 10 sites in United States, Taiwan
- Volunteers
- 24 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Hemorrhagic Stroke, Hemiparesis
Dual Transcranial Direct Current Stimulation (dTDCS)-Enhanced Therapy After Hemorrhagic Strokes and VEGF
This study will evaluate the feasibility of dual tDCS to improve arm motor function in chronic stroke patients. In addition it will collect pilot data on the blood biomarkers associated with treatment effect.
- Trial name
- NCT03857243
- Testing
- dual transcranial direct current stimulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Post-stroke Depression
TMS for Post Stroke Depression
The purpose of this study is to find alternative treatments for patient's suffering from depression after having a stroke.This study aims to show that accelerated rTMS is a safe, effective,and convenient treatment for patient's…
- Trial name
- NCT04093843
- Testing
- TMS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Amelia Adcock
Stroke, Acute Ischemic, Hypertension
TEAMS-BP (The Enhancement of Social Networks to Augment Management of Stroke-Blood Pressure)
This study aims to compare the efficacy of a social network intervention versus individual hypertension counseling to improve blood pressure control after stroke.
- Trial name
- TEAMS-BP (NCT05258890)
- Testing
- Social Network Group Counseling, Individual Counseling
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Brigham and Women's Hospital
Primary Disease
Dabigatran Versus Warfarin After Mitral and/or Aortic Bioprosthesis Replacement and Atrial Fibrillation Postoperatively
DAWA is a phase 2, prospective, open-label, randomized, pilot study. The main variable to be observed in this study is intracardiac thrombus.
- Trial name
- DAWA (NCT01868243)
- Testing
- Dabigatran, Warfarin
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital Ana Nery
Stroke, Gait, Hemiplegic
Gait Training Combined With Behavioral Strategies for People With Stroke
A variety of rehabilitation techniques focused on improving disability after stroke have shown significant changes on walking speed, and endurance. Also, the administration of combined techniques showed better results.
- Conditions
- Stroke, Gait, Hemiplegic, Behavior and Behavior Mechanisms
- Trial name
- NCT04546217
- Testing
- Treadmill training + transfer package (TT+TP), Treadmill training (TT)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Carotid Artery Disease, Carotid Artery Stenosis
The Gore SCAFFOLD Clinical Study
Evaluate the safety and efficacy of the GORE® Carotid Stent for the treatment of carotid artery stenosis in patients at increased risk for adverse events from carotid endarterectomy
- Trial name
- NCT01901874
- Testing
- Carotid Artery Stenting
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- W.L.Gore & Associates
Coma, Traumatic Brain Injury
Continuous Quantified EEG in NeuroIntensive Care
To evaluate the ability of NICU (NeuroIntensive Care Unit) staff to interpret, before and after a training period, symmetry, sedation level, seizures activities and artefact on continuous cEEG/qEEG (continuous…
- Conditions
- Coma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CrazyEEG (NCT02901262)
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Cerebral Infarction
Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler
RATIONALE: Elevation in pulsatility indices (PIs), measured by transcranial Doppler (TCD), has been postulated to reflect downstream increased vascular resistance caused by small-vessel disease (SVD).
- Trial name
- ECLIPse (NCT00741286)
- Testing
- Aspirin, cilostazol
- Where
- 8 sites in South Korea
- Volunteers
- 203 people
- Sponsor
- Inje University
Subarachnoid Hemorrhage, Subdural Hematoma
Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury
The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.
- Conditions
- Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- BFF (NCT03496545)
- Testing
- Bromocriptine 5 MG, Acetaminophen 650 MG
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of California, San Francisco
Pseudobulbar Affect (PBA), Stroke
Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)
The objectives of the study are to evaluate the safety, tolerability, and effectiveness of NUEDEXTA capsules containing 20 mg DM (Dextromethorphan)/10 mg Q (Quinidine) for treatment of Pseudobulbar Affect (PBA) in patients with…
- Conditions
- Pseudobulbar Affect (PBA), Stroke, Dementia, Traumatic Brain Injury (TBI)
- Trial name
- PRISM II (NCT01799941)
- Testing
- Nuedexta (DM 20 mg/Q 10 mg)
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Avanir Pharmaceuticals
Stroke
Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke.
- Trial name
- NCT05906602
- Testing
- Real Ischemic Conditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Hypertension, Ischemic Heart Disease
Add-on Effects of Valsartan on Morbi- Mortality (KYOTO HEART Study)
The KYOTO HEART Study is to assess the add-on effect of valsartan, an Angiotensin-Receptor Blocker, on top of the conventional treatment in high risk patients in Japan with hypertension in terms of the morbidity and mortality.
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure, Stroke
- Trial name
- NCT00149227
- Testing
- Valsartan, Non-ARB
- Where
- Japan
- Volunteers
- 3,031 people
- Sponsor
- Kyoto Prefectural University of Medicine