Clinical trials: tuberculosis
Tuberculosis
Training Inmate Peer Educators in Detecting Tuberculosis in a Developing Country Prison: A Cluster Randomized Trial
Introduction: Finding and successfully treating all tuberculosis (TB) patients is the cornerstone of the Global Strategy to Stop TB. However, many patients in resource-limited countries remain undiagnosed.
- Trial name
- NCT02744521
- Testing
- Symptom-based screening intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maastricht University
HIV Infections, Tuberculosis
Prevalence of HIV and Tuberculosis in Masiphumelele Township, Cape Town, South Africa
The purpose of this study is to estimate the amount of HIV and tuberculosis (TB) infection in individuals 15 years and older in the Masiphumelele township of Cape Town, South Africa.
- Trial name
- NCT00096681
- Volunteers
- 762 people, healthy volunteers welcome
- Sponsor
- CIPRA SA
Tuberculosis, Tuberculosis, Pulmonary
A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults
Partially-Blinded, Placebo-Controlled, Randomized, Single Ascending Dose (SAD) with a Food Effect Cohort to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults.
- Trial name
- NCT03758612
- Testing
- TBI-223 oral suspension, TBI-223 enteric capsule, TBI-223 SR Tablet Prototype 1
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Tuberculosis
Reactogenicity, Safety and Immunogenicity of a TB/FLU-04L Tuberculosis Vaccine
The study is a single centre, phase I, double-blind, randomized, placebo-controlled trial that explored the safety and immunogenicity of 2 doses (Day 1 and Day 21) TB/FLU-04L tuberculosis vaccine versus matched placebo in…
- Trial name
- NCT02501421
- Testing
- tuberculosis vaccine
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Intestinal Tuberculosis, Pulmonary Tuberculosis
Intestinal Tuberculosis Diagnostics and the Differentiation From Crohn's Disease
One aims to devise a method for the screening and differentiation of intestinal tuberculosis and Crohn's Disease. Additionally, one aims to detect and survey multidrug resistant TB.
- Conditions
- Intestinal Tuberculosis, Pulmonary Tuberculosis, Crohn's Disease
- Trial name
- NCT01503099
- Where
- 2 sites in India, Norway
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Lovisenberg Diakonale Hospital
Tuberculosis
Prevalence of Latent Tuberculosis (TB) Infection Diagnosed by Interferon-gamma Release Assay and Tuberculin Skin Tests in Patients With Old Healed TB
We easily regard nodules and fibrosis in upper lobes of lung as TB sequelae. The aim of this study is to confirm the prevalence of latent TB infection diagnosed by interferon-gamma release assay and tuberculin skin tests in…
- Trial name
- NCT01099098
- Where
- South Korea
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Tuberculosis (TB)
Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial
The global incidence rate and mortality of tuberculosis (TB) pose a challenge to achieving the goals set out in the tuberculosis eradication strategy and the SDGs by 2030.
- Trial name
- NCT06963606
- Testing
- Artificial intelligence-assisted chest X-ray in TB screening, Routine doctors analyze the process of chest X-rays
- Where
- China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Xuelin Yang
Tuberculosis (TB)
Safety and Immunogenicity of a Mycobacterium Tuberculosis Vaccine MTBVAC in Healthy Indian Adults and Adolescents (BBV169/2024)
Phase II trial to establish the safety, reactogenicity, and immunogenicity of the MTBVAC with a licensed BCG vaccine as a comparator in both TB naïve (QFT PLUS negative) and TB exposed (QFT PLUS positive) healthy adults and…
- Trial name
- MTBVACph2 (NCT06997367)
- Testing
- MTBVAC, BCG Sii
- Where
- 2 sites in India
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
HIV/AIDS, Tuberculosis
Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load
The standard treatment for TB consists of rifampicin (RIF) as part of the regimen. However, due to drug-drug interactions (DDI), the bioavailability of PIs is greatly reduced when co-administered with RIF necessitating use of…
- Trial name
- DERIVE (NCT04121195)
- Testing
- Dose escalation
- Where
- Uganda
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Tuberculosis Infection
Equivalence Study of Specificity of PPD
Determine if investigational products and reference standard produce similar responses.
- Trial name
- 03 (NCT01798095)
- Testing
- Aplisol@ PPD material, Reference Standard
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- JHP Pharmaceuticals LLC
COVID-19
INTEGrating Ag-RDTs for COVID-19 in MNCH,HIV and TB Services in Cameroon and Kenya
Integration of antigen-detecting rapid diagnostic tests (Ag-RDT) for COVID-19 into services that provide care for vulnerable populations such as pregnant women, children, people with HIV infection, and patients with tuberculosis…
- Trial name
- INTEGRATE (NCT05382130)
- Testing
- Test all
- Where
- 2 sites in Cameroon, Kenya
- Volunteers
- 152,082 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Tuberculosis
Dried Blood Spot Test to Assess TB in Pregnancy
Despite being a key contributor to maternal mortality in high-burden regions, TB in pregnancy is a hugely neglected area of global public health.
- Trial name
- DROPTB2 (NCT04871230)
- Testing
- 3G DBS, Sputum Test, 3G Veinous Blood
- Where
- 12 sites in Madagascar
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Madagascar
Hiv, Hepatitis B
Delivering a Multi-disease Screening Tool to Migrant Populations
Migrants' overall health status may be improved by increasing the detection of certain infectious diseases and other conditions for which effective care is available.
- Conditions
- Hiv, Hepatitis B, Hepatitis C, Tuberculosis
- Trial name
- ISMiHealth (NCT05868005)
- Testing
- Clinical decision support system for screening of migrants using the ISMiHealth software tool.
- Where
- 2 sites in Spain
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
TB - Tuberculosis HIV
Lipoarabinomannan (LAM) in Urine for Diagnosis of Pulmonary Tuberculosis in HIV Patients
A diagnostic validity study in which urinary LAM was done in seropositive HIV patients with symptoms suggestive of TB who were included and investigated with battery of tests to reach the final diagnosis.
- Trial name
- NCT04813666
- Testing
- Urinary LAM ELISA:
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gene Expression, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA
Febrile illness is a common condition, particularly among young patients and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Gene Expression, Gene Expression Profiling, Infection, Viral Diseases
- Trial name
- NCT06838780
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Tuberculosis, Diphtheria
Evaluation of an Infant Immunization Encouragement Program in Nigeria
Previous studies have shown that a small incentive can have a large impact on health behaviors like vaccinating children. New Incentives, an international non-governmental organization (NGO), aims to boost demand for immunization…
- Conditions
- Tuberculosis, Diphtheria, Tetanus, Pertussis
- Trial name
- NCT03870061
- Testing
- All Babies Are Equal Initiative (conditional cash transfer program)
- Where
- 3 sites in Nigeria
- Volunteers
- 5,187 people, healthy volunteers welcome
- Sponsor
- GiveWell
Intestinal Tuberculosis
A 15-year Cohort Study on Risk Factors of Mortality in Patients With Intestinal Tuberculosis
This study adopts a combined design of retrospective cohort study followed by prospective observational study, which is conducted at Beijing Chest Hospital.
- Trial name
- NCT07575061
- Testing
- Observational
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Chest Hospital, Capital Medical University
HIV/AIDS, Tuberculosis
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
The purpose of this trial is to determine if door-to-door is more effective than community gathering in providing voluntary HIV counseling and testing (VCT) in communities in rural Lesotho.
- Conditions
- HIV/AIDS, Tuberculosis, Diabetes Mellitus, Arterial Hypertension
- Trial name
- DoDoPi (NCT01459120)
- Testing
- Door-to-door, Pitso
- Where
- 2 sites in Lesotho
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- SolidarMed
Mycobacterium Tuberculosis
Pharmacokinetic Issues of Moxifloxacin Plus Rifapentine
The purpose of this study is to determine the pharmacokinetics (how a drug is absorbed, distributed, and eliminated by the body) of moxifloxacin alone versus moxifloxacin given with rifapentine.
- Trial name
- NCT00460759
- Testing
- Moxifloxacin, Rifapentine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis, Tuberculosis, Pulmonary
Prevalence of Latent Tuberculosis Infection in Health-care Workers and Students
This study is a cross-sectional study that examines the prevalence of Latent Tuberculosis Infection [LTBI], defined as individuals infected with Mycobacterium tuberculosis with no clinical evidence of disease, and the possible…
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Tuberculosis Infection, Latent Tuberculosis
- Trial name
- CROSSWORD (NCT05756582)
- Testing
- Prevalence of Latent Tuberculosis Infection
- Where
- Italy
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Eleonora Nucera