Clinical trials: tuberculosis
HIV Infections, Tuberculosis
TBTC Study 23: Treatment of HIV-Related Tuberculosis Using a Rifabutin-Based Regimen
Primary objective: To determine the rate of confirmed treatment failure and relapse with an intermittent rifabutin-based regimen for the treatment of isoniazid and rifamycin-susceptible HIV-related tuberculosis (TB).
- Trial name
- NCT00023361
- Testing
- Rifabutin
- Where
- 23 sites in United States, Canada
- Volunteers
- 215 people
- Sponsor
- Centers for Disease Control and Prevention
Tuberculosis, Multidrug-Resistant
Registry on the Effectiveness and Safety of the 9-month MDR-END Treatment Regimen in Korean Patients with FQ-sensitive MDR-TB (MDR-END Registry)
This study is to evaluate the effectiveness and safety of a 9-month MDR-END regimen as a treatment for fluoroquinolone-sensitive multidrug resistant pulmonary tuberculosis in the real-world clinical setting.
- Trial name
- NCT06674291
- Testing
- No intervention (observational study)
- Volunteers
- 222 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Ageing, Tuberculosis
Performance of IGRAs for TB Infection Diagnosis in Elderly
Background: Diagnosis and screening for latent tuberculosis in old patients is of special interest in regards of the morbidity-mortality of this disease in that context.
- Trial name
- IGRage (NCT01895582)
- Testing
- Blood samples
- Where
- 3 sites in France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Tuberculosis
Effectiveness and Cost-Effectiveness of Depression Treatment for Individuals With TB in South Africa
This hybrid type I effectiveness-implementation trial will increase understanding of the effectiveness and cost-effectiveness of integrating a brief evidence-based treatment for major depressive disorder (MDD) within the…
- Trial name
- NCT05091580
- Testing
- Interpersonal Counseling, Enhanced treatment as usual
- Where
- South Africa
- Volunteers
- 500 people
- Sponsor
- New York State Psychiatric Institute
Tuberculosis
Safety Study of ChAdOx1 85A Vaccination With and Without MVA85A Boost in Healthy Adults
This is a Phase I trial to evaluate the safety and immunogenicity of a ChAdOx1 85A vaccination with and without MVA85A boost in healthy BCG vaccinated adults.
- Trial name
- NCT01829490
- Testing
- ChAdOx1 85A, MVA85A
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Specificity Trial of the Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity.
- Trial name
- NCT05203068
- Testing
- Recombinant tuberculosis allergen (RTA)
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Tuberculosis, Hepatotoxicity
NAT2 in Re-challenge of INH in Patients With Hepatitis
Apply the information of NAT2 genotyping into the re-challenge protocol of INH titration in patients with anti-TB medication induced hepatitis.
- Trial name
- NCT00728546
- Testing
- Isoniazid (Rifinah)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Tuberculosis
Diagnostic Usefulness of Interferon Gamma Release Assay for Active Tuberculosis in Immunocompromised Patients
For diagnosis of active tuberculosis, interferon-γ release assay based mycobacterium tuberculosis specific antigen may show higher sensitivity than tuberculin skin test in immunocompromised patients.
- Trial name
- NCT00962676
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Tuberculosis
Essentiality of INH in TB Therapy
Tuberculosis (TB) disease is caused by bacteria that have infected the lung. TB bacteria are very small living agents that are spread by coughing and can be killed by taking TB drugs.
- Trial name
- NCT01589497
- Testing
- Rifampicin, Isoniazid, Pyrazinamide
- Where
- 2 sites in South Africa
- Volunteers
- 69 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Mycobacterial Infection, Tuberculosis (TB)
Patients With Tuberculosis, Mycobacteriosis or Latent Tuberculosis
In the last 30 years, tuberculosis (TB) has re-emerged in industrialised countries as a public health, with a decrease in incidence among the resident population and an increase in the burden of immigrants.
- Trial name
- NCT06764576
- Where
- Italy
- Volunteers
- 13,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Rifampicin Resistant Tuberculosis, Drug-resistant Tuberculosis
Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial
The primary aim of this pragmatic trial is to determine the effectiveness of a Whole Genome Sequencing (WGS) Drug Sensitivity Testing (DST) strategy to guide individualised treatment of rifampicin resistant tuberculosis (RR-TB)…
- Conditions
- Rifampicin Resistant Tuberculosis, Drug-resistant Tuberculosis, Multidrug Resistant Tuberculosis, Pulmonary Tuberculoses
- Trial name
- SMARTT (NCT05017324)
- Testing
- WGS DST strategy
- Where
- South Africa
- Volunteers
- 248 people
- Sponsor
- Universiteit Antwerpen
Malignant Pleural Effusion, Tuberculous Pleural Effusion
Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions
This prospective observational analytical study aims to assess the diagnostic value of Cancer Ratio and Cancer Ratio Plus in differentiating malignant pleural effusion from tuberculous pleural effusion.
- Trial name
- CRPLUS-MPE-TPE (NCT07766876)
- Testing
- Cancer Ratio and Cancer Ratio Plus
- Volunteers
- 120 people
- Sponsor
- Sohag University
Tuberculosis
Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients
The purpose of the study is to study the efficacy and safety of Mycobacterium in treating patients with lung tuberculosis . Mycobacterium is a strain of bacterium which is used as a vaccine and an adjuvant drug against leprosy.
- Trial name
- NCT00265226
- Testing
- Intra-dermal administration of Mycobacterium w
- Where
- 8 sites in India
- Volunteers
- 1,020 people
- Sponsor
- Ministry of Science and Technology, India
Tuberculosis Prevention, HIV
Kulindana: Community-friendly Delivery and Monitoring of TPT to Improve Uptake and Reduce TB Transmission
The goal of this clinical trial is to learn if differentiated service delivery (DSD) of TB preventive therapy (TPT) improves uptake and completion of TPT in two populations: household contacts (HHC) of index TB patients and…
- Trial name
- NCT07628140
- Testing
- Differentiated service delivery (DSD) of TB preventive therapy (TPT)
- Where
- Kenya
- Volunteers
- 1,500 people
- Sponsor
- University of Washington
Tuberculosis
Safety and Immune Responses After Vaccination With Two Investigational RNA-based Vaccines Against Tuberculosis in Healthy Volunteers
This randomized, placebo-controlled, double-blind, safety and dose-finding Phase Ia trial will evaluate four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to select a safe and tolerable dose in a…
- Trial name
- NCT05537038
- Testing
- BNT164a1, BNT164b1
- Where
- 3 sites in Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Tuberculosis, HIV Infections
TB (Tuberculosis) Preventive Therapy for HIV Patients With Access to HAART (Highly Active Antiretroviral Therapy)
The purpose of this study is to determine if implementing a policy of widespread INH (Isoniazid) prophylaxis therapy in HIV-infected patients with access to antiretroviral therapy reduces the incidence of active TB disease in the…
- Trial name
- NCT00107887
- Testing
- INH preventive therapy, TST (tuberculin skin test)
- Where
- Brazil
- Volunteers
- 17,415 people
- Sponsor
- Johns Hopkins University
Mycobacterium Tuberculosis
TB Nutrition, Immunology and Epidemiology
The purpose of this study is to see whether people who take vitamins along with the standard medicine for tuberculosis (TB) recover better and quicker than people who take only the standard medicine for TB.
- Trial name
- NCT00170404
- Testing
- Folic Acid, Micronutrients: Vitamins B1, B2, B6, Niacin, B12, C, E., Selenium
- Where
- Tanzania
- Volunteers
- 887 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vitamin D Deficiency, Tuberculosis
Role of Vitamin D in Innate Immunity to Tuberculosis
The investigators proposed a pilot study preparatory to developing a randomized trial of vitamin D for the prevention of TB infection. The specific aims are presented below: 1.
- Trial name
- NCT01244204
- Testing
- Vitamin D
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Pulmonary Tuberculosis
Epidemiological Study of Hospitalized Children for Pulmonary Tuberculosis at Strasbourg University Hospitals
Pulmonary tuberculosis is the most common form of tuberculosis in children; According to the WHO, tuberculosis pulmonary tuberculosis in children represents approximately 80% of all cases of tuberculosis in children.
- Trial name
- TPE (NCT06110533)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Tuberculosis, Pulmonary
Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis
The current standard management strategy for drug-sensitive pulmonary tuberculosis (TB) is to treat with multiple drugs for 6 months, although patients often fail to adhere to the long treatment, leading to poor clinical outcomes…
- Trial name
- TRUNCATE-TB (NCT03474198)
- Testing
- Rifampicin, Isoniazid, Pyrazinamide
- Where
- 18 sites in India, Indonesia and 4 more
- Volunteers
- 675 people
- Sponsor
- University College, London
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