Clinical trials: tuberculosis
Tuberculosis (TB)
Tuberculosis (TB) Aftermath
TB Aftermath will compare effectiveness, cost-effectiveness and feasibility of two ACF strategies for detecting recurrent TB and provide evidence needed to implement and scale the preferred ACF strategy.
- Trial name
- NCT04333485
- Testing
- Home-based Active Case Finding (HACF), Telephonic Active Case Finding (TACF)
- Where
- India
- Volunteers
- 3,094 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tuberculosis, Spinal, Tuberculosis, Osteoarticular
Gene Expression Profiles in Spinal Tuberculosis.
Tuberculosis (TB) is one of the top ten causes of death worldwide with approximately 10 million cases globally and 1.2 million deaths. Sub-Saharan Africa carries the highest burden of TB.
- Conditions
- Tuberculosis, Spinal, Tuberculosis, Osteoarticular, Tuberculosis, Mycobacterium Infections
- Trial name
- SpinalTBX (NCT05610098)
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- University of Cape Town
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Tuberculosis
PK Study of Anti-TB Drugs
This is a prospective descriptive and pharmacokinetic study will be conducted among newly diagnosed patients registered in the two SMRU TB clinics located on the Thai-Myanmar border.
- Trial name
- NCT02457208
- Testing
- Isoniazid (H), Rifampicin (R), Pyrazinamide (Z)
- Where
- Thailand
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Non-Tuberculous Mycobacterial Pneumonia
A Retrospective Study Investigating the Factors Related to Non-tuberculous Mycobacterial Pulmonary Disease in Hong Kong
In this retrospective study, we aim to investigate the demographic and clinical features of patients with nontuberculous mycobacteria (NTM) lung disease in our hospital and the trends and diversity of NTM species isolated in the…
- Trial name
- NCT04538898
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Lung Cancer, Lung Tuberculosis
68Ga-AlfatideII for the Differential Diagnosis of of Lung Cancer and Lung Tuberculosis by PET/CT
Comparison of 68Ga-AlfatideII and 18F-FDG in differential diagnosis effectiveness towards the solitary pulmonary nodules of lung cancer or tuberculosis.
- Trial name
- NCT02481726
- Testing
- 68Ga-labeled peptides of dimer RGD (Alfatide II) and 18F-FDG
- Volunteers
- 31 people
- Sponsor
- Xijing Hospital
Tuberculosis, COVID-19
Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19
Tuberculosis (TB) is now the commonest cause of death in many African countries. Globally, ~35% (almost 1 in 3) of TB cases are 'missed' (remain undiagnosed or undetected).
- Conditions
- Tuberculosis, COVID-19, HIV Infections
- Trial name
- NCT05220163
- Testing
- CAD, Xpert
- Where
- 3 sites in South Africa, Zambia and 1 more
- Volunteers
- 26,200 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Lymphadenitis, Tuberculous, Immune Defect
Immunology Dysregulation in Lymphadenitis Tuberculosis : An Observational Study Using Patient' Block Paraffins 2019 Until 2021
Mycobacterium tuberculosis (M. tuberculosis) infection is still a problem that cannot be overcome in Indonesia. In 2018 the number of tuberculosis (TB) sufferers in Indonesia reached more than 850/100,000 population, an increase…
- Trial name
- NCT05202548
- Testing
- Immuno-histochemical staining
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Katolik Widya Mandala Surabaya
Mycobacterium Tuberculosis Infection
Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants
The trial is designed as a phase III, double-blind, multicenter, randomized, single administration, active-controlled, parallel-group design with two groups of newborn infants receiving either VPM1002 or BCG SII (1:1 allocation)…
- Trial name
- VPM1002 (NCT04351685)
- Testing
- VPM1002, BCG SII
- Where
- 12 sites in Gabon, Kenya and 3 more
- Volunteers
- 6,940 people, healthy volunteers welcome
- Sponsor
- Serum Institute of India Pvt. Ltd.
HIV Infections, Tuberculosis
Safety, Tolerability, and Blood Levels of Ritonavir-Boosted Atazanavir and Rifampin When Taken Together in HIV Uninfected Adults
Rifampin (RIF) is used for the treatment of tuberculosis (TB), an infectious disease that affects many people with HIV. RIF was shown to lower concentrations and decrease the effectiveness of some anti-HIV drugs, including the…
- Trial name
- NCT00096850
- Testing
- Atazanavir, Rifampin, Ritonavir
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, HIV Infections
Improving HIV/Tuberculosis Outcomes in Irkutsk
The investigators propose to examine the prospective influence of substance use patterns on HIV/tuberculosis adherence, pharmacokinetics and disease progression while developing novel methods for early detection and correction of…
- Conditions
- Tuberculosis, HIV Infections, Substance Use
- Trial name
- NCT03819374
- Where
- Russia
- Volunteers
- 53 people
- Sponsor
- University of Virginia
Tuberculosis, Pulmonary
Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC
Pulmonary Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries (LMIC), where resources for healthcare are often limited.
- Trial name
- CUSTB (NCT06409780)
- Testing
- Comparative analysis of CUS, CAD and CXR in pulmonary TB
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Bari
Tuberculosis
Evaluation of Safety, Immunogenicity, and Prevention of TB With AERAS-404 and BCG Revaccination in Healthy Adolescents
Randomized, Placebo Controlled, Partially Blinded Phase II Study to Evaluate Safety, Immunogenicity, and Prevention of Infection with Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy Adolescents
- Trial name
- NCT02075203
- Testing
- AERAS-404, Bacillus Calmette-Guérin (BCG)
- Where
- 2 sites in South Africa
- Volunteers
- 989 people, healthy volunteers welcome
- Sponsor
- Aeras
Tuberculosis, Pulmonary
Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide
Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been unsuccessful.
- Trial name
- HIGHSHORT-RP (NCT04694586)
- Testing
- rifampicin, pyrazinamide, HRZE
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- University Hospital, Linkoeping
Tuberculosis
Moxifloxacin As Part of a Multi-Drug Regimen For Tuberculosis
Current treatment of tuberculosis (TB) requires patients to take four drugs for 8 weeks and then two drugs for 4 months. New drug regimens that are shorter and effective against drug-resistant TB are needed.
- Trial name
- NCT00082173
- Testing
- Moxifloxacin
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- Johns Hopkins University
Tuberculosis
Diagnostic Innovations for Pediatric Tuberculosis in Bolivia
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture…
- Trial name
- NCT06113861
- Testing
- Quantiferon Gold, HIV serology, Respiratory secretion culture (sputum or gastric aspirate_
- Where
- Bolivia
- Volunteers
- 1,220 people
- Sponsor
- Tulane University
Tuberculosis
Assessing the Ability of the T-SPOT®.TB Test (IQ)
The primary objective of this clinical research study is to demonstrate performance of the normalized TB specific lymphocyte response (NTBSLR) in identifying patients with active TB disease.
- Trial name
- IQ (NCT03973970)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Oxford Immunotec
Pulmonary Tuberculosis
Effect of Vitamin D as Adjunctive Therapy in Patients With Pulmonary Evolution Tuberculosis
Tuberculosis (TB) is the second largest infectious disease that causes death in the last 4 centuries in all the world. Observational studies found an association between vitaminD and TB, suggesting a potential therapeutic role of…
- Trial name
- VitaminD (NCT02464683)
- Testing
- VitaminD
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Tuberculosis, Pulmonary
Evaluation of PET/MRI Using a Somatostatin Analog Tracer as a Novel Approach to Detecting Pathology in High Risk TB-exposed Contacts
PET/MRI (positron emission tomography/magnetic resonance imaging) with somatostatin analog tracers has the potential to provide an imaging technique targeting subclinical granulomatous disease in those with latent tuberculosis…
- Trial name
- NCT02967666
- Testing
- FDG ligand, DOTANOC ligand
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Tuberculosis (TB), Tuberculosis Treatment Effectiveness
Butterfly Pea Flower (Clitoria Ternatea) for Adjuvant TB Treatment
The goal of this clinical trial is to learn if butterfly pea flowers (Clitoria ternatea) decocta extract works to treat as adjuvant therapy for tuberculosis in adults.
- Trial name
- NCT06794502
- Testing
- Herbal medicine, Tuberculosis (TB) treatment
- Where
- 2 sites in Indonesia
- Volunteers
- 28 people
- Sponsor
- Universitas Muhammadiyah Semarang
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