Clinical trials: tuberculosis
HIV/AIDS, Tuberculosis
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
The purpose of this trial is to determine if door-to-door is more effective than community gathering in providing voluntary HIV counseling and testing (VCT) in communities in rural Lesotho.
- Conditions
- HIV/AIDS, Tuberculosis, Diabetes Mellitus, Arterial Hypertension
- Trial name
- DoDoPi (NCT01459120)
- Testing
- Door-to-door, Pitso
- Where
- 2 sites in Lesotho
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- SolidarMed
Cystic Fibrosis, Pediatrics
A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida
To determine the prevalence of nontuberculous mycobacterial infection (NTM) in pediatric patients with cystic fibrosis in the State fo Florida.
- Trial name
- NCT02198079
- Testing
- Sputum
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Miami
Tuberculosis
Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects
This is a Phase 1, single-center, randomized, balanced, single-dose, two-treatment, two-period, two-sequence, crossover, open-label study to evaluate the effect of food on the pharmacokinetics of PA-824.
- Trial name
- CL-003 (NCT01828827)
- Testing
- PA-824 1000 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Global Alliance for TB Drug Development
Healthy
The Safety of Tuberculosis Treatments by Oral Inhalation
The inhaled route of delivery has always been associated with the considerable challenge of getting the drug to its target. The lungs are a highly complex organ designed to filter inspired air, with many different cell types…
- Trial name
- NCT01785927
- Testing
- ABCD
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Mycobacterium Tuberculosis, Protection Against, Tuberculosis
ChAdOx1 85A Aerosol Versus Intramuscular Vaccination in Healthy Adults (TB039)
This is a dose escalating and a paired-placebo design study to describe the safety and immunogenicity profile of candidate TB vaccine ChAdOx1 85A given by aerosol inhaled vaccination versus intramuscular (IM) vaccination in adult…
- Trial name
- TB039 (NCT04121494)
- Testing
- ChadOx1 85A - aerosol, ChadOx1 85A - IM
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- François Spertini
Tuberculosis
Using SMS Reminders, Phone Calls and Money Incentives to Enhance Linkage to Care of Presumptive TB Patients in Uganda
The major challenge in meeting the WHO's End TB Strategy- reducing tuberculosis (TB) deaths by 90% and incidence by 80% is the cascading patient loss-to-follow-up (LTFU) along the continuum of TB care.
- Trial name
- MILEAGE4TB (NCT05964842)
- Testing
- SMS, Phone call, Mobile money incentive
- Where
- 5 sites in Uganda
- Volunteers
- 2,355 people
- Sponsor
- Makerere University
Tuberculosis
A Trial of the C-Tb Skin Test, When Given Intradermally to Adult Patients Recently Diagnosed With Active Tuberculosis (TB)
Tuberculosis (TB) continues to be the most important bacterial infection worldwide and therefore new improved diagnostic tests are needed to help doctors in diagnosing TB. The new skin test is named C-Tb.
- Trial name
- TESEC-04 (NCT01241188)
- Testing
- C-Tb, 2 TU Tuberculin PPD RT 23 SSI
- Where
- South Africa
- Volunteers
- 253 people
- Sponsor
- Statens Serum Institut
Pulmonary Tuberculosis
Randomized Trial for Pharmacogenomics-based Tuberculosis Therapy (RT-PGTT)
The purpose of this study is to elucidate whether the individualized medicine based on NAT2 gene polymorphism could improve the safety, efficacy and economical benefits of multi-drug therapy for the pulmonary tuberculosis with…
- Trial name
- NCT00298870
- Testing
- Isoniazid, isoniazed
- Where
- 4 sites in Japan
- Volunteers
- 172 people
- Sponsor
- Osaka University
Pulmonary Tuberculosis
Tuberculosis Volatile Organic Compounds
The Pulmonary Colonization Test is a non-invasive breath test for markers of lower respiratory tract infection, which may predict the probability of mycobacterial organisms in the lower respiratory tract.
- Trial name
- TBVOC (NCT01379066)
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Pulmonary Tuberculosis
A Clinical Trial to Study the Effect of the Addition of Vitamin D to Conventional Treatment in New Pulmonary Tuberculosis Patients
There is some evidence that supplemental Vitamin D may contribute to quicker recovery from TB when given in addition to normal TB therapy. This needs to be proven with a controlled clinical trial.
- Trial name
- NCT00366470
- Testing
- A. 100,000 IU Cholecalciferol per dose of 3.3ml, B. Migliol Oil without Cholecalciferol
- Where
- 2 sites in India
- Volunteers
- 250 people
- Sponsor
- Peter Daley
Tuberculosis
Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya
Isoniazid preventive therapy (IPT) is a well studied clinical intervention for primary and secondary prevention of active tuberculosis (TB) after infection with Mycobacterium tuberculosis.
- Trial name
- IPT (NCT00850915)
- Testing
- community IPT
- Where
- 18 sites in Kenya
- Volunteers
- 1,259 people, healthy volunteers welcome
- Sponsor
- KNCV Tuberculosis Foundation
Bursa; Tuberculous, Hip Bursitis
Trochanteric Bursal Repair After a Total Hip Replacement - Are There Benefits During the First 90 Days
During total hip arthroplasty surgery, the trochanteric bursa is routinely excised. This anatomical structure, which functions as a soft tissue barrier, is generally recommended for removal as it facilitates the surgical…
- Conditions
- Bursa; Tuberculous, Hip Bursitis, Deep Gluteal Syndrome, Hip Disease
- Trial name
- NCT06553508
- Testing
- Trochanteric bursa repaired, Trochanteric bursa unrepaired
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Ankara City Hospital Bilkent
Tuberculosis, Spinal
The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis
The purpose of this study is to determine the better preoperative anti-tuberculosis treatment period of patients with spinal tuberculosis.
- Trial name
- NCT02477852
- Testing
- Isoniazid, Rifampicin, Ethambutol
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Chest Hospital
Pulmonary and Extra- Pulmonary Tuberculosis (TB)
Study About Drug Resistance of Mycobacterium Tuberculosis
Tuberculosis is a major cause of ill health and one of the leading causes of death worldwide. Early, rapid and accurate diagnosis of all TB patients and prompt treatment with any form of drug-susceptible or drug resistant TB is…
- Trial name
- NCT07169149
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Tuberculosis
Precision Rifampin Trial for Personalized Dosing
Individual pharmacokinetic variability is an important driver of tuberculosis (TB) treatment failure particularly among undernourished populations, and that suboptimal serum drug concentrations are associated with delayed…
- Trial name
- P-RIF (NCT06318416)
- Testing
- urine spectrophotometry for rifampin absorbance
- Where
- Tanzania
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Latent Tuberculosis Infection
Nurse-Led Community Health Worker Adherence Model in 3HP Delivery Among Homeless Adults at Risk for TB Infection and HIV
Tuberculosis (TB) is the prototypical disease of poverty as it disproportionately affects marginalized and impoverished communities.
- Trial name
- 3HP-LTBI (NCT03702049)
- Testing
- Nurse-led Community Health Worker TBI (RN/CHW TBI) program
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, Irvine
Tuberculosis
TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial
Background: Non-Steroid Anti-Inflammatory Drugs (NSAIDs) reduce pain and inflammation by inhibiting cyclooxygenase, an enzyme in the pathway for formation of prostaglandins and thromboxane.
- Trial name
- NCT02060006
- Testing
- Meloxicam 7.5mg daily for 8 weeks
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- University of Stellenbosch
Neurological Disorders, Cerebral Malaria
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management.
- Conditions
- Neurological Disorders, Cerebral Malaria, Bacterial Meningitis, Central Nervous System Tuberculosis
- Trial name
- Nidiag-Neuro (NCT01589289)
- Testing
- Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics)
- Where
- Democratic Republic of the Congo
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Tuberculosis
Pretomanid in Adults With Hepatic Impairment
This is a Phase 1, single dose (200 mg), open-label study comparing the pharmacokinetics and safety of Pretomanid in subjects with mild, moderate, and severe hepatic impairment to matched, non-hepatically impaired subjects.
- Trial name
- NCT02422524
- Testing
- PA-824
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Children LTBI
A Multicentre, Cohort Study of Screening and Preventive Intervention for Latent Tuberculosis Infection in Children
The management of latent Mycobacterium tuberculosis infection is a new priority action for the WHO End Tuberculosis (TB) Strategy.
- Trial name
- NCT04156568
- Testing
- INH、RFT
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Children's Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.