Clinical trials: tuberculosis
Impaired Quality of Life, Pulmonary Tuberculosis (TB)
Breathing Exercise and Tele-Nursing Support for Patients With Tuberculosis: A Single-Group Experimental Study
This study was conducted as a single-group, pretest-posttest quasi-experimental design. The sample consisted of 54 tuberculosis patients registered at a Tuberculosis Dispensary who met the inclusion criteria and agreed to…
- Trial name
- TELEBREATH (NCT07069205)
- Testing
- Tele-nursing supported respiratory exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Canan Güngör
Tuberculosis Infection
Dose Study of Tuberculin Purified Protein Derivative (JHP/Dose)
Dose comparison study of tuberculin purified protein derivative (PPD)Aplisol with the standard tuberculin purified derivative (PPD-S2).
- Trial name
- NCT01689831
- Testing
- To confirm the potency of Aplisol formulated with newly produced Tuberculin PPD compared to PPD-S2 standard., Reactivity of Aplisol compared to reference standard PPD-S2.
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- JHP Pharmaceuticals LLC
Tuberculosis
Cali Sin Tos Aim 2
The overall objective of this Aim is to design and iteratively adapt a home-based, mHealth- and oral testing facilitated strategy for implementing tuberculosis (TB) contact tracing in Cali, Colombia.
- Trial name
- NCT06338462
- Testing
- Chatbot, Oral testing
- Where
- Colombia
- Volunteers
- 269 people
- Sponsor
- Yale University
Tuberculosis
Specificity Trial of the Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity.
- Trial name
- NCT05203068
- Testing
- Recombinant tuberculosis allergen (RTA)
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Tuberculosis
Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers
The purpose of this study is to evaluate the bactericidal activity against Mycobacterium tuberculosis of pyrazinamide in combination with allopurinol.
- Trial name
- NCT02700347
- Testing
- Pyrazinamide, Allopurinol
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Tuberculosis, Pulmonary
Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB
The performance of a new triage test for active tuberculosis (TB), SeroSelectTB, will be qualified in multi-centre randomised controlled trials at health-posts in South Africa, Tanzania and Ethiopia.
- Trial name
- SeroSelectTB (NCT04752592)
- Testing
- SeroSelectTB rapid TB test
- Where
- 3 sites in Ethiopia, South Africa and 1 more
- Volunteers
- 9,097 people
- Sponsor
- Norwegian Institute of Public Health
Tuberculosis Infection, HIV Infections
Computer Aided Screening for Tuberculosis in Low Resource Environments
People living with HIV (PLHIV) who require admission to hospital in WHO Africa region have poor outcomes. TB is very common in this group, but can be difficult to diagnose.
- Trial name
- CASTLE (NCT04545164)
- Testing
- CAD4TB, FujiLAM
- Where
- Malawi
- Volunteers
- 498 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Tuberculosis
Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
The objective of the study was to compare the compliance and the side effects of a short course to treatment of latent tuberculosis infection during 3 months(isoniazid plus rifampin)group I, with the standard course for 6…
- Trial name
- NCT00397709
- Testing
- I ( isoniazid), II (isoniazid + rifampin )
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Virgen de la Luz
Rheumatoid Arthritis, Spondylarthritis
Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
The purpose of this study is to evaluate the value of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists.
- Conditions
- Rheumatoid Arthritis, Spondylarthritis, Tuberculosis
- Trial name
- TNFTB (NCT00491933)
- Testing
- Quantiferon-TB Gold assay, Tuberculin skin test
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Infection, Human Immunodeficiency Virus, HIV Infections
Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
This is a Phase I, single-center, open-label, fixed-sequence, 2-period crossover study in healthy adults to evaluate the effect of oral rifabutin (RBT) 300 milligram (mg) on the pharmacokinetics of oral cabotegravir (CAB) 30…
- Trial name
- NCT03149848
- Testing
- Cabotegravir, Rifabutin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Tuberculosis
TBTC Study 25PK: Intensive Pharmacokinetic Study of Three Doses of Rifapentine and 25-Desacetyl Rifapentine
Primary objective: To compare the pharmacokinetics of rifapentine and 25-desacetyl rifapentine at three different doses: 600 mg, 900 mg, and 1200 mg.
- Trial name
- NCT00023387
- Testing
- Rifapentine, 25-desacetyl Rifapentine, Isoniazid
- Where
- 23 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, Tuberculosis
Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection
To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with…
- Trial name
- NCT00000638
- Testing
- Isoniazid, Pyrazinamide, Pyridoxine hydrochloride
- Where
- 76 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis Infection
Safety and Tolerability of Chlorquine in Addition to Anti-tuberculosis Therapy
In vitro and in vivo data show promising results of adjunctive use of Chloroquine to standard tuberculosis therapy as Chloroquine enhances animicrobial effectiveness against intracellular MTB.
- Trial name
- NCT05443178
- Testing
- Nivaquine ® (Chloroquine)
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Tuberculosis, Tuberculosis (TB)
Shaping a Community-based Pathway to Improve TB Surveillance Among African and Hindustan Immigrants Experiencing Vulnerabilities
This two-phase, mixed-methods approach project aims to develop a community-based, participatory, and co-created TB/TB infection (TBI) screening care pathway for African and Hindustan immigrants, who often face socioeconomic…
- Conditions
- Tuberculosis, Tuberculosis (TB), Tuberculosis Active, Tuberculosis Infection, Latent
- Trial name
- AFROHINDU-MIGT (NCT07687121)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Tuberculosis, Tuberculosis, Pulmonary
Treating Tuberculosis Wasting With a High-protein Supplement
Undernutrition at the time of diagnosis of active tuberculosis is a risk factor for increased mortality, and lack of weight gain during anti-tuberculous treatment has been linked to an increased relapse risk.
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Undernutrition, Malnutrition
- Trial name
- NUTRIATO (NCT03302949)
- Testing
- Lacprodan® DI-8090
- Where
- Guinea-Bissau
- Volunteers
- 232 people
- Sponsor
- University of Aarhus
Recurrent Tuberculosis
Improving Retreatment Success (IMPRESS)
This is an open label randomized controlled clinical trial comparing two regimens for treatment of smear-positive pulmonary TB, among patients previously treated for TB.
- Trial name
- IMPRESS (NCT02114684)
- Testing
- moxifloxacin
- Where
- South Africa
- Volunteers
- 197 people
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
Tuberculosis, HIV
Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama
Tuberculosis (TB) is one opportunistic infection often seen in HIV individuals. In 2013, there were an estimated 31,800 HIV-TB co-infection cases and 6,100 HIV-related deaths due to TB in the Americas.
- Conditions
- Tuberculosis, HIV, Histoplasmosis
- Trial name
- NCT02911740
- Testing
- Urine LAM Ag test
- Sponsor
- University of Florida
Tuberculosis Diagnosis
Evaluation of New TB Diagnostic Tests (NATs) in Pakistan
This study evaluates two portable molecular tests for tuberculosis (TB), Pluslife MTBC and Ustar PortNAT, during community-based active case-finding activities in Pakistan.
- Trial name
- TB (NCT06984887)
- Testing
- Paired tongue-swab and sputum-based molecular testing for tuberculosis
- Where
- 2 sites in Pakistan
- Volunteers
- 6,100 people, healthy volunteers welcome
- Sponsor
- Mercy Corps Pakistan
Tuberculosis, Non-Tuberculous Mycobacterial Pneumonia
Multiplex PCR -Microarray-based Assay in the Detection of Mycobacterium
The study will use the VereMTB tool for rapid diagnosis of TB or non-tuberculous mycobacterium (NTM) pulmonary infections in hospitalised patients, with positive results in acid-fast bacilli smears, which are emerging in many…
- Trial name
- NCT03794284
- Testing
- VereMTB
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- Chinese University of Hong Kong
Multi-drug Resistant Tuberculosis
Clinical Study on Adoptive Treatment of MDR-TB With Allogeneic γδT Cells
Brief summary: Allogeneic γδT cells from healthy donor will be administrated intravenously to patients with the MDR-TB，and then the safety and efficacy of γδT cells will be evaluated.
- Trial name
- MDR-TB (NCT03575299)
- Testing
- The adoptive treatment of allogeneic γδT cells, Control, Conventional treatment
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Zhinan Yin, Ph.D.
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