Clinical trials: in Benin
Red Blood Cell Disorder
Pathophysiological Explorations of Red Blood Cells
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of…
- Trial name
- GR-Ex (NCT03541525)
- Testing
- Biological sampling
- Where
- 25 sites in Benin, France and 1 more
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pregnancy Related
Evaluation of Electronic Pregnancy Registers and Mobile Applications for Monitoring Pregnancy Outcomes ( EVAPREAP )
Monitoring pregnancy outcomes during pregnancy is very important in assessing the effectiveness of interventions. This study aims to create pregnancy registers and evaluate pregnancy mobile applications as a potential tool for…
- Trial name
- NCT06225739
- Testing
- Electronic pregnancy register, In-depth interviews and focus group discussions
- Where
- 4 sites in Benin, Burkina Faso and 2 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria, Anemia
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NNP (NCT03931473)
- Testing
- Bed nets
- Where
- Benin
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID19, Coronavirus
Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting
The study is a double-blind, randomised, placebo-controlled trial that will be conducted primarily in healthcare settings and other facilities directly involved in COVID-19 case management.
- Conditions
- COVID19, Coronavirus, Acute Respiratory Illnesses
- Trial name
- COPCOV (NCT04303507)
- Testing
- Chloroquine or Hydroxychloroquine
- Where
- 25 sites in Benin, Côte d’Ivoire and 8 more
- Volunteers
- 4,652 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Malariae Infection, SMC
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin
This study aims to evaluate the effects of SMC (Seasonal malaria chemoprevention) with Sulfadoxine-Pyrimethamine (SP) and Amodiaquine (AQ) on the evolution of anti-malarial immunity of children and their susceptibility to…
- Conditions
- Plasmodium Malariae Infection, SMC, Immune System Disease
- Trial name
- ISAMIMA (NCT05650502)
- Testing
- saisonal malaria chimoprevention
- Where
- Benin
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Université de Parakou
Iron Absorption
Iron Long-Term Labelling Study Benin
Conventional indirect indicators of iron status, using serum and red blood cell biomarkers, are confounded by inflammation from common infections in sub-Saharan Africa, a region with a high prevalence of iron deficiency, making…
- Trial name
- NCT02979080
- Testing
- Eisensulfat LOMAPHARM 50 mg
- Where
- 2 sites in Benin
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Prof. Michael B. Zimmermann
Malaria, Antepartum
Safety and Immunogenicity of the Placental Malaria Vaccine Candidate PAMVAC Variously Adjuvanted
Despite having developed robust acquired immunity against complications of malaria, women can return to a susceptible state during their first pregnancies and contribute significantly to the burden of severe malaria in highly…
- Trial name
- PAMVAC (NCT02647489)
- Testing
- PAMVAC, Alhydrogel, GLA-SE
- Where
- Benin
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Adherence to Medication Regime
Early Antiretroviral Therapy and Pre-exposure Prophylaxis for HIV Prevention Among Female Sex Workers in Cotonou, Benin
In the last few years, early treatment of HIV-infected individuals, or "treatment as prevention (TasP), and pre-exposure prophylaxis with antiretroviral drugs among HIV-negative people at very high-risk of acquiring the infection…
- Trial name
- TasP/PrEP (NCT02237027)
- Testing
- TasP using ART regimen as per Benin guidelines, PrEP using Truvada
- Where
- Benin
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Surgery, Surgery- Complications
African Surgical Outcomes Study (ASOS)
STUDY OBJECTIVE To confirm the incidence of in-hospital postoperative complications in adult surgical patients in Africa. STUDY DESIGN Seven day, African national multi-centre prospective observational cohort study of adult (≥18…
- Conditions
- Surgery, Surgery- Complications, Mortality
- Trial name
- ASOS (NCT03044899)
- Testing
- All surgeries in adult patients
- Where
- 25 sites in Algeria, Benin and 23 more
- Volunteers
- 11,422 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
Malaria, Antepartum, Maternal Malaria During Pregnancy - Baby Not Yet Delivered
Community-based Screening and Treatment of Malaria in Pregnancy: a Cluster-randomized Trial
Malaria is a common disease in Africa and a major health problem. Pregnant women are also at risk of malaria. Malaria in pregnancy is life threatening to both the mother and the baby she is carrying.
- Conditions
- Malaria, Antepartum, Maternal Malaria During Pregnancy - Baby Not Yet Delivered, Small for Gestational Age (Disorder)
- Trial name
- COSMIC (NCT01941264)
- Testing
- community based screening and treatment
- Where
- 3 sites in Benin, Burkina Faso and 1 more
- Volunteers
- 4,265 people, healthy volunteers welcome
- Sponsor
- Royal Tropical Institute
HIV Infection
Cellulose Sulfate and HIV Transmission Among Women
The purpose of the study is to determine the effect of cellulose sulfate on the transmission of HIV to women via vaginal intercourse.
- Trial name
- NCT00153777
- Testing
- Cellulose Sulfate gel (6%)
- Where
- 5 sites in Benin, India and 2 more
- Volunteers
- 1,428 people, healthy volunteers welcome
- Sponsor
- CONRAD
Intermittent Preventive Treatment In Pregnancy (IPTp)
Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa
The primary objective is to establish superiority of AZCQ over SP in protective efficacy for IPTp as measured by the proportion of subjects with sub-optimal pregnancy outcome.
- Trial name
- NCT01103063
- Testing
- Azithromycin plus chloroquine, sulfadoxine-pyrimethamine
- Where
- 9 sites in Benin, Kenya and 3 more
- Volunteers
- 2,891 people, healthy volunteers welcome
- Sponsor
- Pfizer
Zinc Deficiency
Water-based Zinc Efficacy Trial in Beninese Shool Children
The general objective of this study is to determine the effect of the daily consumption of zinc-fortified water provided by the LSF-filter on zinc status and diarrhea rates in school age children from rural areas characterized by…
- Trial name
- NCT01790321
- Testing
- LSF-filtering device
- Where
- Benin
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Prof. Michael B. Zimmermann
Pregnancy, Malaria
Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy
The study aims at comparing the safety, tolerability and efficacy of Mefloquine (MQ) to Sulfadoxine-Pyrimethamine (SP) as Interment Preventive Treatment in pregnancy (IPTp) for the prevention of malaria effects on the mother and…
- Conditions
- Pregnancy, Malaria, HIV Infections
- Trial name
- MiPPAD (NCT00811421)
- Testing
- Sulphadoxine-pyrimethamine, Mefloquine (full dose), Mefloquine (split dose)
- Where
- 5 sites in Benin, Gabon and 3 more
- Volunteers
- 5,820 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Zinc Deficiency, Diarrhea
Water-based Zinc Intervention Trial in Zinc Deficient Children
The overall aim of this trial is to determine whether the use of the household-based water treatment device Life Straw Family (LSF) can be an effective strategy to improve zinc status and health status of vulnerable populations…
- Trial name
- NCT01472211
- Testing
- zinc enriching filter (LifeStrawFamily), disinfection tablets
- Where
- Benin
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency, Anemia
Iron Absorption From Complementary Food Fortificants (CFFs) and Acceptability of CFFs by Beninese Children
Iron deficiency (ID) is still a main public health problem in sub-Saharan Africa. Iron deficient children have an increased risk for anemia which is associated with adverse infant development that might be partly irreversible.
- Trial name
- NCT01321099
- Testing
- NaFeEDTA, Phytase, Vitamin C
- Where
- Benin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency, Biofortification
Iron Absorption From Regular, Biofortified and Post-harvest Fortified Pearl Millet
Iron deficiency (ID) with or without anemia is still a main public health problem in sub-Saharan Africa and Southern Asia, especially in vulnerable population groups such as children below 5 years of age and women of reproductive…
- Trial name
- NCT01634932
- Testing
- Regular iron, Iron biofortified millet, Post-harvest iron-fortifed millet
- Where
- Benin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology