Clinical trials: completed, in Cambodia
Hospital Infections, Environment, Controlled
CLEAN Frontline: A Stepped Wedge Cluster Trial
Environmental hygiene is a key component of infection prevention in healthcare, and a driver of healthcare associated infections.
- Conditions
- Hospital Infections, Environment, Controlled, Infection Control
- Trial name
- NCT05540886
- Testing
- TEACH CLEAN
- Where
- Cambodia
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Vivax Malaria, Plasmodium Vivax
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
Health care facility based, randomized, controlled, open label, superiority trial with 3 arms
- Conditions
- Vivax Malaria, Plasmodium Vivax, Malaria, Vivax, Malaria Relapse
- Trial name
- EFFORT (NCT04411836)
- Testing
- Tafenoquine, Primaquine
- Where
- 6 sites in Cambodia, Ethiopia and 2 more
- Volunteers
- 960 people
- Sponsor
- Menzies School of Health Research
Pregnancy Related, Antenatal Care
Multiple Micronutrient Supplementation vs Iron and Folic Acid Among Pregnant Women in Cambodia
Iron and folic acid (IFA) supplements are currently provided to Cambodian women during pregnancy. However, recent research has showed benefit of a multiple micronutrient supplement (MMS) over just IFA alone on several outcomes of…
- Conditions
- Pregnancy Related, Antenatal Care, Iron Folic Acid Supplementation
- Trial name
- MMS-Cambodia (NCT05867836)
- Testing
- IFA vs. MMS during pregnancy
- Where
- Cambodia
- Volunteers
- 1,545 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Fever
Clinical Evaluation of the FilmArray® Global Fever (GF) Panel
This study will evaluate the clinical sensitivity and specificity of the FilmArray Global Fever (GF) Panel.
- Trial name
- NCT02968355
- Testing
- Observational study
- Where
- 11 sites in United States, Cambodia and 8 more
- Volunteers
- 2,084 people
- Sponsor
- BioFire Defense LLC
Anemia, Iron Deficiency, Anemia
Potential Harms of Untargeted Iron Supplementation in Cambodia Where Iron Deficiency is Not the Cause of Anemia
In 2016, the World Health Organization (WHO) set a global policy recommending daily oral iron supplementation (60 mg iron) for 12 weeks for all women living in countries where anemia prevalence is >40%, such as in Cambodia.
- Conditions
- Anemia, Iron Deficiency, Anemia, Intestinal Inflammation, Inflammation
- Trial name
- NCT04017598
- Testing
- Ferrous sulfate, Ferrous Bisglycinate
- Where
- Cambodia
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dengue Fever, Zika
Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia
Background: Zika, dengue, and chikungunya are spread by mosquitos. These diseases have a major impact on public health. This is especially true in in Southeast Asia.
- Conditions
- Dengue Fever, Zika, Vector-Borne Diseases, Chikungunya
- Trial name
- NCT04434846
- Where
- Cambodia
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiratory Distress Syndrome, Lower Respiratory Tract Infection
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is…
- Trial name
- NCT04311320
- Testing
- Low-Resource Oxygen Blender
- Where
- Cambodia
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
Plasmodium Falciparum Malaria (Uncomplicated)
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)
A partially blinded randomised controlled non-inferiority trial comparing the efficacy, tolerability and safety of Triple ACTs artemether-lumefantrine + amodiaquine (AL+AQ) and artesunate- mefloquine+piperaquine (AS-MQ+PPQ) with…
- Trial name
- DeTACT-ASIA (NCT03939104)
- Testing
- Artemether-lumefantrine+amodiaquine, Artesunate-mefloquine+piperaquine
- Where
- 3 sites in Bangladesh, Cambodia
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Malaria
Study to Assess Efficacy of Artemether-lumefantrine Prophylaxis Against Forest Malaria in Cambodia (PAL_Cambodia)
In the Greater Mekong Subregion (GMS) adults are at highest risk for malaria. The most relevant disease vectors bite during daytime and outdoors which makes forest work a high-risk activity for malaria.
- Trial name
- PAL_Cambodia (NCT04041973)
- Testing
- Artemether-lumefantrine, Multivitamin
- Where
- 2 sites in Cambodia
- Volunteers
- 1,480 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Noncommunicable Disease, Infections
Rural South and Southeast Asia Household Health Survey
A cross-sectional household survey with two-stage cluster-randomized sampling. This cross-sectional household survey design to recruit a random sample of households that is representative for each of the study sites.
- Conditions
- Noncommunicable Disease, Infections, Risk Factors, Health Status
- Trial name
- SEACTN-HHS (NCT05389540)
- Where
- 4 sites in Bangladesh, Burma and 2 more
- Volunteers
- 4,747 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Strongyloides Stercoralis Infection
Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis
The study is an extension to the study StrongMoxi NCT04056325 and entails modifications based on the outcome of NCT04056325 part A. The study is a phase 3, double-blinded and randomized clinical trial conducted in Cambodia.
- Trial name
- StrongMoxi_KH (NCT04848688)
- Testing
- Moxidectin 2 mg, Ivermectin 3 mg
- Where
- Cambodia
- Volunteers
- 332 people
- Sponsor
- Jennifer Keiser
Hiv
ANRS 12415 - Quali PrEP Cambodia
Hypothesis: Hypothesis 1 : Regarding the recentness of preexposure prophylaxis (PrEP) implementation with an uptake of 20% and according to the first consultative meeting, awareness and acceptability of PrEP seems to be low in…
- Trial name
- ANRS 12415 (NCT05091489)
- Testing
- Qualitative assessment about PrEP acceptability
- Where
- Cambodia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Soil-transmitted Helminth Infections
Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP2 (NCT04177654)
- Testing
- Benzimidazoles
- Where
- 8 sites in Bangladesh, Cambodia and 6 more
- Volunteers
- 9,457 people
- Sponsor
- University Ghent
Diabetes Mellitus
GlucoVIP - Diabetes Treatment by Glucobay® With a Special Therapeutic View to Chosen Patient Groups
Evaluation of safety and effectiveness of Glucobay® under daily-life treatment conditions in a large sample of patients.
- Trial name
- NCT00909051
- Testing
- Acarbose (Glucobay, BAYG5421)
- Where
- 16 sites in Algeria, Bosnia and Herzegovina and 14 more
- Volunteers
- 15,729 people
- Sponsor
- Bayer
Household Food Security
Food Security and Nutrition in Rural Cambodia
The project is a three arm randomized control trial in rural Cambodia designed to evaluate the impact of homestead food production (home gardens) with and without fish ponds versus control on household food security, dietary…
- Trial name
- NCT01593423
- Testing
- plant-based Homestead Food Production, Homestead Food Production plus small pond aquaculture, a comparison group
- Where
- Cambodia
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sepsis
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and…
- Trial name
- SPOT-SEPSIS (NCT04285021)
- Where
- 6 sites in Bangladesh, Cambodia and 3 more
- Volunteers
- 3,433 people
- Sponsor
- Medecins Sans Frontieres, Spain
Rabies
Immunity Persistence After Abridged Intradermal Rabies PEP
After exposure, rabies can be prevented in almost 100% of cases by the administration of sufficient and timely post-exposure prophylaxis (PEP).
- Trial name
- RESIST-3 (NCT04829630)
- Testing
- rabies vaccine
- Where
- 2 sites in Cambodia, Madagascar
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Mental Health, Distress, Emotional
Friendship Group Intervention Development in Cambodia
A Friendship Group (FG's) (n= 4) will be delivered over an 8-week period (December 2021 - January 2022) to individuals who met the clinical distress threshold as per Kessler-10 score.
- Conditions
- Mental Health, Distress, Emotional, Worry
- Trial name
- NCT05725707
- Testing
- Friendship Group
- Where
- Cambodia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Rabies Post-exposure Prophylaxis
Immunogenicity Assessment of Subjects Receiving Rabies Post-exposure Prophylaxis in Cambodia
A rabies virus neutralizing antibody (RVNA) concentration ≥ 0.5 IU/ml at 14 days after immunization is considered a proxy for protection in vaccine efficacy studies.
- Trial name
- NCT05684185
- Testing
- Intramuscular (IM) rabies post-exposure prophylaxis, Intradermal (ID) rabies post-exposure prophylaxis
- Where
- Cambodia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Tuberculosis
Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia
Tuberculosis (TB) is a highly stigmatized disease, and approximately one-third of the Cambodian population living with TB are undetected.
- Trial name
- NCT04094350
- Testing
- ACF with a seed-and-recruit model, ACF targeting household and neighborhood contacts, ACF targeting the older population using mobile screening units
- Where
- 3 sites in Cambodia
- Volunteers
- 2,004 people
- Sponsor
- National University of Singapore