Clinical trials: in Cambodia
Dengue Fever
Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children
Background: Some mosquitos carry viruses that can cause disease. Some examples are dengue and Zika. The mosquitos spread disease by biting people and infecting them with the virus.
- Trial name
- NCT03534245
- Where
- Cambodia
- Volunteers
- 775 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Vivax Malaria
Southeast Asia Dose Optimization of Tafenoquine
Tafenoquine was recently approved by regulatory authorities in the USA and Australia. Tafenoquine is an alternative radical curative treatment to primaquine acting against the dormant liver stage of Plasmodium vivax (the…
- Trial name
- SEADOT (NCT04704999)
- Testing
- Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg
- Where
- 6 sites in Cambodia, Indonesia and 3 more
- Volunteers
- 820 people
- Sponsor
- University of Oxford
Febrile Illness
Incidences, Causes, and Outcomes of Febrile Illness in Rural South and Southeast Asia
The study will collect information to understand the causes and outcomes of febrile illness in rural areas in countries across South and Southeast Asia (including Cambodia, Laos, Myanmar and Bangladesh).
- Trial name
- SEACTN-WP-A (NCT04478578)
- Where
- 7 sites in Bangladesh, Burma and 3 more
- Volunteers
- 82,760 people
- Sponsor
- University of Oxford
Tuberculosis in Children
Impact of an Innovative Childhood TB Diagnostic Approach Decentralized to District Hospital and Primary Health Care Levels on Childhood Tuberculosis Case Detection and Management in High Tuberculosis Incidence Countries (TB-Speed Decentralisation)
The TB-Speed Decentralisation study aims to increase childhood Tuberculosis (TB) case detection at district hospital (DH) and Primary health Care (PHC) levels using adapted and child-friendly specimen collection methods, i.e.
- Trial name
- NCT04038632
- Testing
- Decentralization of Childhood TB Diagnosis
- Where
- 59 sites in Cambodia, Cameroon and 4 more
- Volunteers
- 3,106 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Underweight, Overweight and Obesity
SHIFT-TB: Nutrition Intervention and Evaluation
The goal of this trial is to evaluate a community-based nutrition intervention for adults in Cambodia who are underweight or overweight/obese.
- Trial name
- NCT07836322
- Testing
- Community-Based Nutrition Intervention
- Where
- Cambodia
- Volunteers
- 700 people
- Sponsor
- National University of Singapore
Melioidosis
Environment, Pathogens, and Host Interactions in Melioidosis
This is a longitudinal, multicentre observational study conducted across three established microbiology units integrated within hospital and community health systems in Thailand, Lao PDR, and Cambodia.
- Trial name
- DeEPH (NCT07345910)
- Where
- 3 sites in Cambodia, Laos and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Diabetes
BGM and HbA1c POC Device Evaluation
This study aims to assess analytical performance of four BGMs and four HbA1c POC devices in comparison to suitable comparator or reference methods, with the view to evaluate performance in the hands of trained users, as well as…
- Trial name
- NCT06170515
- Testing
- CareSens N-Eco (i-Sens), • CareSens N-Premier (i-Sens), CodeFree (SD Biosensor), GlucoNavii GDH (SD Biosensor), Affinion (Abbott), HbA1c 501 (HemoCue), A1Care (iSens), DCA Vantage (Siemens)
- Where
- 3 sites in Cambodia, Colombia and 1 more
- Volunteers
- 910 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Vector-Borne Diseases, Emerging Pathogens
Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Background: Vector-borne diseases are caused by the bite of an infected mosquito, fly, flea, tick, or other blood-feeder. These diseases cause almost 1 million deaths per year.
- Trial name
- NCT04034264
- Where
- 6 sites in Cambodia
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, AIDS
Community-Based Model for Delivery of Antiretroviral Therapy in Cambodia
The community-based ART delivery (CAD) model will build on the existing framework to engage community action, operationalized in the current Global Fund-supported project.
- Trial name
- NCT04766710
- Testing
- Community-based ART delivery (CAD), ART multi-month dispensing (MMD)
- Where
- 3 sites in Cambodia
- Volunteers
- 4,049 people
- Sponsor
- National University of Singapore
Hospital-acquired Infections
Infection Prevention and Control Intervention to Reduce Hospital-acquired Infections
Hospital-acquired infections (HAIs) are significant public health issues, especially in low- and middle-income countries (LMICs).
- Trial name
- IPC-HAI (NCT05547373)
- Testing
- Infection prevention and control (IPC)
- Where
- Cambodia
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Maternal and Child Health
An Innovative Mobile Technology Intervention for Maternal and Child Health Care in Cambodia
The Innovative Mobile Technology for Maternal and Child Health Care (i-MoMCARE) project is a digital health intervention aiming to increase the coverage of and access to maternal and child health (MCH) services for pregnant women…
- Trial name
- i-MoMCARE (NCT05639595)
- Testing
- Web interface for health center staff and mobile application on smart phones for village health volunteers
- Where
- Cambodia
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Neurocognition, Child
Early Life Thiamine Study
Thiamine (vitamin B1) is an important nutrient needed for energy metabolism, brain development, and overall health. However, low thiamine intake is a concern in countries where white rice is the main staple since it contains…
- Trial name
- NCT07795996
- Testing
- Multiple micronutrient supplementation
- Where
- Cambodia
- Volunteers
- 1,972 people
- Sponsor
- Mount Saint Vincent University
Human Papillomavirus Vaccination, Cervical Cancer Prevention
Integrating HPV Education Into School Health Programs in Cambodia and Kenya
The Clinton Health Access Initiative conducted a mixed-methods, school-based interventional study in Cambodia and Kenya to evaluate whether integrating age-appropriate human papillomavirus (HPV) education into existing school…
- Trial name
- NCT07784283
- Testing
- Integrated HPV Education
- Where
- 5 sites in Cambodia, Kenya
- Volunteers
- 9,054 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Smoking Cessation, HIV
Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS
The goal of this research study is to test how well an automated text messaging smoking treatment program helps smokers with HIV quit smoking.
- Trial name
- ProjectENDIT (NCT05746442)
- Testing
- Smartphone-delivered Automated Messaging, Nicotine patch, Brief Advice to Quit and Smoking Cessation Self Help Materials
- Where
- 3 sites in Cambodia
- Volunteers
- 800 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hypoxemia, Neonatal Disease
Evaluation of a Multi-country Medical Oxygen Program
REAL-MOXY is a set of 5 mixed methods studies designed to understand how oxygen and pulse oximetry are used (or not used) at a facility level, to identify opportunities and barriers for strengthening oxygen systems for…
- Conditions
- Hypoxemia, Neonatal Disease, Pneumonia, Sepsis
- Trial name
- REAL-MOXY (NCT06087315)
- Testing
- Multi-faceted oxygen systems strengthening interventions (different for each country)
- Where
- 3 sites in Cambodia, Nigeria and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Murdoch Childrens Research Institute
Core Competency, Patient Safety
Procedure Manual-Based Simulation Training to Improve Operating Room Nurses' Core Competencies
This study aims to evaluate the effectiveness of a procedure manual-based simulation training program in improving the core competencies of operating room nurses in a Cambodian national hospital.
- Conditions
- Core Competency, Patient Safety, Interprofessional Collaboration, Surgical Outcome
- Trial name
- NCT07527429
- Testing
- Procedure Manual-Based Simulation Training
- Where
- Cambodia
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Vivax Malaria
Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure
The study will be an open-labelled randomized clinical trial to determine therapeutic efficacy. Note that this will not be an Investigational New Drug application, as only World Health Organization (WHO)-approved drugs will be…
- Trial name
- NCT04706130
- Testing
- Primaquine, Artesunate
- Where
- Cambodia
- Volunteers
- 160 people
- Sponsor
- University of Maryland, Baltimore
Immunity, Humoral
Characterization of Human Immune Signatures to Zoonotic Virus Exposure in Cambodia
This is a biospecimen procurement protocol to characterize the immune response to zoonotic virus exposure in healthy adult humans aged 18 to 65 years with high-risk exposure to animals or their excreta (e.g., guano farming and…
- Trial name
- Camzoo (NCT06680843)
- Testing
- Whole blood collection
- Where
- 5 sites in Cambodia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exposure to Environmental Pollution, Exposure to Household Air Pollution
Applied Implementation Research for Clean Cooking in Cambodia
The goal of this study is to learn how to help families in Cambodia switch to using electric induction stoves instead of traditional stoves that burn wood or charcoal.
- Trial name
- AIR-C3 (NCT06942715)
- Testing
- Electric Induction Cookstoves
- Where
- Cambodia
- Volunteers
- 6,150 people, healthy volunteers welcome
- Sponsor
- Emory University