Clinical trials: in Cambodia
Falciparum Malaria
Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia
There are worrying signs that parasitological responses to the artemisinin drugs for uncomplicated falciparum malaria are slower than elsewhere in the world.If responses to artesunate are poor it is essential to have…
- Trial name
- NCT00493363
- Testing
- Artesunate, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Malaria, Vivax
Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse
The purpose of this two part study is to test the safety and efficacy of Tafenoquine (with Cholorquine) as a radical cure for Plasmodium vivax (P.vivax) malaria relative to the control Chloroquine.Part 1 aims to select an…
- Trial name
- NCT01376167
- Testing
- Chloroquine 600mg, Chloroquine 300mg, Tafenoquine 50mg
- Where
- 14 sites in Bangladesh, Brazil and 6 more
- Volunteers
- 851 people
- Sponsor
- GlaxoSmithKline
Reproductive Health, Sexual Health
Using a Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia
In Cambodia, HIV is prevalent in several high-risk groups including among female entertainment workers (FEWs) who work at entertainment venues such as karaoke bars and massage parlors and may engage in direct or indirect sex…
- Trial name
- NCT03117842
- Testing
- Automated text and voice messages
- Where
- Cambodia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Malaria
Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
Plasmodium falciparum parasite clearance rates (PCRs) after oral artesunate treatment of patients with uncomplicated malaria were recently found to be significantly slower in Pailin (Western Cambodia) compared to Wang Pha…
- Trial name
- NCT01240603
- Where
- Cambodia
- Volunteers
- 415 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anemia, Anemia, Iron-Deficiency
Lucky Iron Fish Home Fortification of Iron
The purpose of this research is to determine if cooking with an iron ingot called the Lucky Iron Fish (LIF) increases the hemoglobin status in women of childbearing age living in Preah Vihear, Cambodia.
- Conditions
- Anemia, Anemia, Iron-Deficiency, Hemoglobinopathies
- Trial name
- NCT02341586
- Testing
- Lucky Iron Fish - home fortification system, 18 mg elemental iron, Nutrition Education
- Where
- Cambodia
- Volunteers
- 340 people
- Sponsor
- University of British Columbia
Phantom Limb Pain, Complex Regional Pain Syndromes
A Clinical Trial of Mirror Treatment for Phantom Pain
A randomized controlled clinical to examine the effect of mirror therapy on phantom pain and residual limb pain in patients with traumatic transtibial amputations in Cambodia.
- Trial name
- NCT02912975
- Testing
- Mirror treatment, Tactile treatment
- Where
- Cambodia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Trauma Care Foundation, Norway
Hepatitis C, HIV
Monitoring Liver Disease Progression in Hepatitis C/HIV Co-infected Patients With No-to-moderate Fibrosis, in Phnom Penh, Cambodia
Data on the progression of liver fibrosis in patients co-infected with HIV taking effective suppressive antiretroviral therapy with no fibrosis or mild-to-moderate fibrosis at baseline are scarce.
- Trial name
- HCV-Monitoring (NCT02628691)
- Testing
- Liver fibrosis progression
- Where
- Cambodia
- Volunteers
- 70 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Severe Malaria, Malaria
Severe Malaria and Anti-malarial Drug Resistance in Cambodia
This study, conducted by the National Center for Malaria Control of Cambodia's Ministry of Health, the Guangzhou University of Traditional Chinese Medicine in the People's Republic of China, and the U.S.
- Conditions
- Severe Malaria, Malaria, Antimalarial Drug Resistance
- Trial name
- NCT00341003
- Where
- Cambodia
- Volunteers
- 2,090 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Cambodia Integrated HIV and Drug Prevention Implementation Program
HIV risk among female entertainment and sex workers (FESW) remains high and use of amphetamine-type stimulants (ATS) significantly increases this risk.
- Trial name
- CIPI (NCT01835574)
- Testing
- Conditional cash transfer and cognitive-behavioral aftercare
- Where
- Cambodia
- Volunteers
- 1,198 people
- Sponsor
- University of California, San Francisco
HIV Infections, HIV Seronegativity
Daily Tenofovir DF to Prevent HIV Infection Among Sex Workers in Cambodia
Tenofovir disoproxil fumarate (also known as tenofovir DF or Viread) is used with other anti-HIV drugs to treat HIV infection. Taking tenofovir DF every day may also prevent HIV infection.
- Trial name
- NCT00078182
- Testing
- Tenofovir DF
- Where
- Cambodia
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Visceral Leishmaniasis, Human African Trypanosomiasis
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
Tropical fevers have been a diagnostic challenge from the antiquity. Nowadays, despite the availability of good diagnostic capacities, undifferentiated febrile illnesses continue to be a thorny problem for travel physicians.
- Conditions
- Visceral Leishmaniasis, Human African Trypanosomiasis, Enteric Fever, Melioidosis
- Trial name
- NCT01766830
- Testing
- rk28 ICT, IT LEISH (rK39), Immunochromatographic HAT test
- Where
- 7 sites in Cambodia, Democratic Republic of the Congo and 2 more
- Volunteers
- 1,927 people
- Sponsor
- University Hospital, Geneva
Dengue Fever
International Research Consortium on Dengue Risk Assessment, Management, and Surveillance
Improvements in diagnosis of dengue fever and prediction of which patients will get more severe disease are urgently needed to improve the treatment of patients with dengue.
- Trial name
- IDAMS (NCT01550016)
- Testing
- Observation
- Where
- 9 sites in Bangladesh, Brazil and 6 more
- Volunteers
- 7,411 people
- Sponsor
- University of Heidelberg Medical Center
Child Malnutrition
Efficacy of a Multiple Micronutrient-Fortified Lipid-Based Nutrient Supplement for Children Under Two in Cambodia
The purpose of this trial is to evaluate the efficacy of the LNS on children aged 6-17 months in preventing growth faltering and improving micronutrient status.
- Trial name
- NCT02257762
- Testing
- LNS, Corn-soy blend ++ (CSB++), Sprinkles
- Where
- Cambodia
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement, Cambodia
Child Malnutrition
Acceptability of a Multiple Micronutrient-Fortified Lipid-Based Nutrient Supplement for Children Under Two in Cambodia
The purpose of this trial is to evaluate the acceptability of the LNS to women and their children aged 12-17 months in comparison to Corn Soy Blend++, and Sprinkles added to borbor (white rice porridge, which is the traditional…
- Trial name
- NCT02257437
- Testing
- LNS snack, Corn-soy blend ++ (CSB++), Sprinkles
- Where
- Cambodia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement, Cambodia
Malaria, Falciparum, G6PD Deficiency
Safety and Tolerability of Low Dose Primaquine
In Cambodia, falciparum is becoming more difficult to treat because drugs are becoming less effective. The investigators can help to try to prevent the spread of this resistant malaria by adding a drug that will make it more…
- Trial name
- NCT02434952
- Testing
- Dihydroartemisinin piperaquine (DHA PP), Primaquine
- Where
- Cambodia
- Volunteers
- 109 people
- Sponsor
- Malaria Consortium
HIV
National Evaluation of PI-based 2nd Line Efficacy in Cambodia
Medium and long term efficacy of PI-based 2nd line antiretroviral (ARV) therapy in Cambodia is poorly documented when the numbers of patients on treatment and their duration are increasing.
- Trial name
- NCT01801618
- Where
- 13 sites in Cambodia
- Volunteers
- 15,001,351 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Malaria
Malaria Prevention Cambodia
Trial of monthly DHA-piperaquine for malaria prevention in health volunteers.
- Trial name
- MPC (NCT01624337)
- Testing
- DHA-piperaquine
- Where
- Cambodia
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Thiamin Deficiency
Thiamin Fortified Fish Sauce as a Means of Combating Infantile Beriberi in Rural Cambodia
The purpose of this study is to determine whether consumption of thiamin fortified fish sauce over 6 months increases the thiamin status of women to a level consistent with a low risk of infantile beriberi.
- Trial name
- NCT02221063
- Testing
- Thiamin fortified fish sauce (low concentration), Thiamin fortified fish sauce (higher concentration)
- Where
- Cambodia
- Volunteers
- 366 people
- Sponsor
- University of British Columbia
Hepatitis C, HIV
Determination of HCV Prevalence in a HIV Patient Cohort in Phnom Penh, Cambodia
Hepatitis C (HCV) is an important global public health problem, disproportionately affecting HIV positive populations. Asia and Africa account for most of the co-infection burden, but access to HCV screening and treatment is…
- Trial name
- HCV-Epi (NCT02361541)
- Testing
- HCV screening
- Where
- Cambodia
- Volunteers
- 3,045 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Multi-drug Resistant Tuberculosis
A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis
The purpose of this study is to provide safety and efficacy data for TMC207 and to demonstrate that TMC207 added to a background regimen (BR) is superior to treatment with the BR plus placebo.
- Trial name
- NCT01600963
- Testing
- Arm A Double-blind Phase: TMC207, Treatment Failure During Double-blind Phase: TMC207, Treatment Failure During Follow-up Phase: TMC207
- Where
- 44 sites in Brazil, Cambodia and 15 more
- Sponsor
- Janssen Infectious Diseases BVBA