Clinical trials: in Cambodia
Cervical Neoplasia, Cervical Cancer
Cervical Cancer Screening in HIV Positive and Negative Women in Cambodia
The prevalence of cervical neoplasia in Cambodia is not known. There are no screening programs in place. The investigators plan on introducing a screening program based on WHO criteria and utilizing visualization with acetic…
- Trial name
- NCT02253719
- Testing
- cryotherapy, further biopsy, LEEP, surgery as indicated
- Where
- Cambodia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sihanouk Hospital Center of HOPE
HIV, Tuberculosis
Improving Diagnosis of Tuberculosis in HIV Infected Children in Asia (Cambodia, Vietnam)and Africa (Burkina Faso, Cameroon)
Childhood tuberculosis (TB) accounts for 11% of the total 9 million annual TB cases and the difficulty of its diagnosis is increased in case of HIV infection in children.
- Conditions
- HIV, Tuberculosis, Pediatrics
- Trial name
- NCT01331811
- Testing
- Development of a diagnosis algorithm
- Where
- 8 sites in Burkina Faso, Cambodia and 2 more
- Volunteers
- 441 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Uncomplicated Plasmodium Falciparum Malaria
Antimalarial Drug Resistance With Assessment of Transmission Blocking Activity
This is a two-arm, open label Treatment Study comparing the efficacy, safety, tolerability and pharmacokinetics of a three-day course of Dihydroartemisinin-Piperaquine (DP) with or without single-dose primaquine in patients with…
- Trial name
- NCT01849640
- Testing
- DHA-piperaquine and Primaquine
- Where
- Cambodia
- Volunteers
- 150 people
- Sponsor
- David Saunders
Neonatal Infection
Newborn Infection Control and Care Initiative for Health Facilities to Accelerate Reduction of Newborn Mortality
Newborn mortality continues to be unacceptably high in Cambodia, despite reductions in maternal and under five year old mortality.
- Trial name
- NICCI (NCT02271737)
- Testing
- Training HC/VHSG, Health Education, and Supportive Supervision
- Where
- Cambodia
- Volunteers
- 1,938 people
- Sponsor
- National Institute of Public Health, Cambodia
Dengue, Disease Progression
Ability of Bedside Ultrasound to Predict Progression of Severity of Disease in Dengue Fever
The purpose of this study is determine the ability of bedide ultrasound performed in the Emergency Department and Outpatient Department can predict the severity of disease during a Dengue Fever outbreak in children, in Siem Reap…
- Trial name
- NCT02134652
- Testing
- diagnostic bedside ultrasound
- Where
- Cambodia
- Sponsor
- University of Massachusetts, Worcester
Falciparum Malaria
Tracking Resistance to Artemisinin (TRAC)
Because the artemisinins are the most potent antimalarial drugs, the reduction in parasite numbers is rapid. Therefore, early measures of reducing parasite counts are needed.
- Trial name
- TRAC (NCT01350856)
- Testing
- Artesunate 2, Artesunate 4
- Where
- 19 sites in Bangladesh, Burma and 8 more
- Volunteers
- 1,700 people
- Sponsor
- University of Oxford
Wound, Re-Epithelialization
Phenytoin in the Healing of Clean Surgical Wounds
The purpose of this study is to investigate the potential healing properties of phenytoin. The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial…
- Trial name
- NCT02413658
- Testing
- Phenytoin, Sugar solution
- Where
- Cambodia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Surgical Center, Cambodia
Neurocognitive Development
A Sub-study of PREDICT Neurodevelopment Protocol
To determine the neurodevelopment (ND) in normal children in Thailand and Cambodia and to use this group to compare the neurodevelopmental changes over time to the HIV-infected children with and without HAART (main study).
- Trial name
- NCT02406768
- Where
- 10 sites in Cambodia, Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Vivax Malaria
Assessment of Plasmodium Vivax Chloroquine Resistance in Cambodia:
The investigators propose to leverage the unique infrastructures and expertise of National Centre for Parasitology Entomology and Malaria Control and the Pasteur Institute in Cambodia and combine modern fieldwork, including a…
- Trial name
- CRePViCam (NCT02118090)
- Testing
- Chloroquine sulfate, DHA-PP
- Where
- Cambodia
- Volunteers
- 73 people
- Sponsor
- Institut Pasteur, Cambodia
Micronutrient Status
Fortified Rice for School Children in Cambodia
Rice fortification has been shown to be safe and effective in improving micronutrient status in many studies around the world. However, most studies have been done in Latin America, Africa and India.
- Trial name
- FORISCA (NCT01706419)
- Testing
- Fortified rice cold extruded kernel, fortified rice warm extruded kernel, fortiified rice hot extruded kernel
- Where
- Cambodia
- Volunteers
- 9,500 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Ascaris Lumbricoides, Ascaris Suum
Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Objectives: The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH). The primary objective is: (1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against…
- Conditions
- Ascaris Lumbricoides, Ascaris Suum, Trichuris Trichiura, Trichuris Vulpis
- Trial name
- ConWorm (NCT01379326)
- Testing
- Mebendazole
- Where
- 9 sites in Argentina, Australia and 6 more
- Volunteers
- 250 people
- Sponsor
- University Ghent
Maternal and Newborn Health
Effects of a Fortified Dietary Supplement for Pregnant Women on Maternal and Newborn Outcomes in Kampong Chhnang Province, Cambodia
The study will evaluate the effects of a nutrition supplement for pregnant women on birth weight and other outcomes. The hypothesis is pregnant women who consume a daily fortified food supplement will produce babies with a higher…
- Trial name
- NCT01413776
- Testing
- Corn Soya Blend+
- Where
- Cambodia
- Volunteers
- 547 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HIV Infections
When to Start Anti-HIV Drugs in Children Infected With HIV (The PREDICT Study)
The purpose of this study is to determine when HIV infected children should begin taking anti-HIV medications in order to improve both patient quality of life and survival.
- Trial name
- NCT00234091
- Testing
- Abacavir, Efavirenz, Lamivudine
- Where
- 9 sites in Cambodia, Thailand
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Beriberi
Pharmacokinetics of Thiamine in Breastfeeding Mothers and Infants
Thiamine deficiency causes beriberi and is common in parts of rural Cambodia, where it appears to be a leading cause of infant death.
- Trial name
- NCT01864057
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States, Cambodia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HIV Infection, Tuberculosis
Early vs Late Introduction of Antiretroviral Therapy in HIV-infected Patients With Tuberculosis (ANRS 1295 CAMELIA)
In Cambodia the prevalence of both tuberculosis (TB) and Human Immunodeficiency Virus (HIV) infection is high. Data suggest that aggressive management of HIV infection, which includes Anti-Retroviral Therapy (HAART) during…
- Trial name
- NCT00226434
- Testing
- Early antiretroviral treatment, Late antiretroviral treatment
- Where
- 5 sites in Cambodia
- Volunteers
- 661 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infection, Pregnancy
Tenofovir/Emtricitabine for PMTCT in Africa and Asia (ANRS 12109 TEmAA)
To study the pharmacokinetic properties, safety and viral resistance pattern of the combination of tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their newborns, with a view to prevention of…
- Trial name
- TEmAA (NCT00334256)
- Testing
- Tenofovir (TDF), Emtricitabine (FTC)
- Where
- 3 sites in Cambodia, Côte d’Ivoire and 1 more
- Volunteers
- 72 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Dysentery, Diarrhoea
Solar Disinfection (SODIS) of Drinking Water for Use in Developing Countries or in Emergency Situations
SODISWATER was a health impact assessment study investigating the effect of sunlight to inactivate microbial pathogens in drinking water.
- Trial name
- SODISWATER (NCT01306383)
- Testing
- SODIS Bottle
- Where
- 3 sites in Cambodia, Kenya and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Infections With Soil-Transmitted Helminths (STH)
A Multinational Trial of the Efficacy of Albendazole Against Soil-transmitted Nematode Infections in Children
The three major Soil-Transmitted Helminths (STH), Ascaris lumbricoides, Necator americanus/Ancylostoma duodenal and Trichuris trichiura are among the most prevalent parasites worldwide.
- Trial name
- WORMCON (NCT01087099)
- Testing
- Albendazole
- Where
- 7 sites in Brazil, Cambodia and 5 more
- Volunteers
- 1,750 people
- Sponsor
- University Ghent
Falciparum Malaria
Artemisinin Resistance in Cambodia II
The purpose of this study is to determine the impact of varying doses of artesunate on treatment outcome and whether higher doses of artesunate can overcome the problem of compromised artemisinin sensitivity in the region.
- Trial name
- ARC II (NCT00722150)
- Testing
- Artesunate
- Where
- Cambodia
- Volunteers
- 143 people
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Breast Neoplasms, Uterine Cervical Neoplasms
Early Detection of Cancers in Low Resource Countries
The purpose of this study is to implement a community-based combined program for early detection of breast, cervical, ovarian and endometrial cancer in low-resource countries delivered through a free standing or a mobile Well…
- Conditions
- Breast Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms
- Trial name
- NCT01178736
- Testing
- Breast Cancer Screening and Diagnosis, Cervical Cancer Screening and Diagnosis, Ovarian Cancer Screening and Diagnosis
- Where
- 3 sites in Brazil, Cambodia and 1 more
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- Woman's Cancer Foundation