Clinical trials: suspended, in Canada
Monkeypox
Tecovirimat in Non-hospitalized Patients With Monkeypox
PLATINUM-CAN is a parallel collaborative trial linked with the sister trial PLATINUM led by Oxford University. PLATINUM-CAN is a multi-centre, randomized, placebo-controlled trial of Tecovirimat in non-hospitalized patients with…
- Trial name
- PLATINUM-CAN (NCT05534165)
- Testing
- Tecovirimat
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Marina Klein
Major Depressive Disorder, Suicide
Identifying the Neural Basis of Capability for Suicide
Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system.
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation, Psychiatric Illness
- Trial name
- NCT03327129
- Testing
- fMRI
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Fertility Issues, Embryo Implantation
Rescue Progesterone Supplementation During Frozen Embryo Transfer
Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet…
- Conditions
- Fertility Issues, Embryo Implantation, Frozen Embryo Transfer
- Trial name
- P4R (NCT05555121)
- Testing
- Progesterone Effervescent Vaginal Tablet
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Clinique Ovo
Prostate Cancer, Node; Prostate
Pelvic Nodes Ultra-Hypo vs Conventionally Fractionated IMRT With HDR Boost in Prostate Cancer.
Randomized Phase III study, comparing pelvic ultra-hypo fractionated radiotherapy (UHF: 5Gy/fraction) to a standard or moderate hypo-fractionation (1.8-2.15Gy/fraction), both associated to an HDR prostate +/- adjacent seminal…
- Conditions
- Prostate Cancer, Node; Prostate, Radiotherapy Side Effect
- Trial name
- PCS-XI (NCT05820633)
- Testing
- Report and compare changes in a non-inferiority analysis of the International Prostate Symptom Score (I-PSS), Report and compare changes in a non-inferiority analysis of the expanded prostate cancer index composite" (EPIC-26):, Report and compare changes in a non-inferiority analysis of the Sexual Health Inventory for Men (SHIM)
- Where
- 11 sites in Canada
- Volunteers
- 500 people
- Sponsor
- CHU de Quebec-Universite Laval
Depression Anxiety Disorder
Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety
Major depression and anxiety disorders are leading causes of disability worldwide. These mental disorders deeply impact social functioning and physical health in more than 300,000-600,000 Canadians over the age of 60.
- Trial name
- NCT03607708
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Enhancement Program (HEP)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Lady Davis Institute
Breast Cancer
Postoperative Identification of Tumor Cells At the Lumpectomy Site of Patients with Early Breast Cancer
For early breast cancer, local surgery followed by breast radiation is a standard local treatment. It has been found that the original primary tumor site, the lumpectomy site, is the commonest location of local relapse.
- Trial name
- NCT04339517
- Testing
- Aspiration of seroma fluid
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Urinary Incontinence
Trial to Assess the Safety and Clinical Performance of Contino® in Preventing Urinary Incontinence
This trial is to assess the safety and clinical performance of Contino device is preventing Urinary Incontinence in male subjects with Sphincteric Incompetence
- Trial name
- NCT04165408
- Testing
- Contino
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- CMX Research
Wheelchairs
Wheelchair Provision Time for Hospital Inpatients
In a Pilot Study, the median Wheelchair Lead Time (from when a wheelchair was ordered by an Occupational Therapist for an inpatient in the Central Zone of Nova Scotia Health to when the wheelchair arrived at the destination…
- Trial name
- NCT06566040
- Testing
- Wheelchair
- Where
- Canada
- Volunteers
- 119 people
- Sponsor
- Nova Scotia Health Authority
Breast Cancer, Surgery--Complications
Surgical and Patient Reported Outcomes of Robotic Nipple-Sparing Mastectomy
Nipple-sparing mastectomy (NSM) with immediate reconstruction is one of the standard of care surgical treatments of breast cancer (BC) and is used for risk reduction in patients with a high risk for BC.
- Conditions
- Breast Cancer, Surgery--Complications, Genetic Predisposition to Disease, Surgery
- Trial name
- RNSM (NCT04151368)
- Testing
- Robotic Nipple-Sparing Mastectomy (RNSM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Bone Resorption, Bone Loss
Bone Response to Exercise and Energy Restriction in Young Adults
Cycling is commonly questioned whether it provides adequate mechanical strain on bone as many elite cyclists have been found to have a low bone mass.
- Trial name
- NCT04345250
- Testing
- Energy restriction
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Brock University
Post Traumatic Stress Disorder
Early Prevention of PTSD in Patients Within One Week of Acute Physical Trauma
The objective of this study is to assess the feasibility and effectiveness of AEPET plus Resilience Based Therapy (RBT) versus RBT alone for the prevention of PTSD and depression in trauma patients.
- Trial name
- NCT02915497
- Testing
- Abbreviated Early Prolonged Exposure Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Rheumatoid Arthritis, Degenerative Arthritis
Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)
A post market, prospective, non-randomized, multi-center, open-label,clinical study using survivorship as the reference performance goal to study the safety and efficacy of the Cadence Total Ankle System (TAS) when used for…
- Conditions
- Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
- Trial name
- Cadence (NCT03142958)
- Testing
- Integra Cadence Total Ankle System
- Where
- 11 sites in United States, Canada
- Volunteers
- 132 people
- Sponsor
- Smith & Nephew, Inc.
Stroke, Acute
Endovascular Acute Stroke Intervention Trial - the EASI Trial
Stroke constitutes the primary cause of acquired disability in adults and the second cause of dementia following Alzheimer disease.
- Trial name
- EASI (NCT02157532)
- Testing
- mechanical thrombectomy, Best standard treatment
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Aphakia
Artisan Aphakia Lens for the Correction of Aphakia in Children
The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.
- Trial name
- NCT01547442
- Testing
- Artisan Aphakia Intraocular Lens
- Where
- 19 sites in United States, Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ophtec USA
Tongue Cancer
Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue Cancer
This is a pilot study in the form of a prospective Phase II, single centre, single arm hypoxia study of oral tongue cancer with FAZA-PET imaging and pimonidazole targeted IHC of surgical specimens.
- Trial name
- FAITH (NCT03181035)
- Testing
- (18)F-Fluoroazomycin arabinoside, Pimonidazole
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Aphakia
Artisan Aphakia Lens for the Correction of Aphakia (Secondary) in Adults
This study will determine the safety and effectiveness of the Artisan Aphakia Lens when used as a secondary implant to correct aphakia in adults.
- Trial name
- NCT01547429
- Testing
- Artisan Aphakia Intraocular Lens
- Where
- 18 sites in United States, Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ophtec USA
Fragile X Syndrome, Behavior
An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X Syndrome
Diverse symptomatology makes Fragile X Syndrome (FXS) difficult to treat, and currently there are no approved prevention or treatment methods for FXS.
- Conditions
- Fragile X Syndrome, Behavior, Cognitive Dysfunction
- Trial name
- NCT05832255
- Testing
- Psilocybin, 1.5 mg
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Nova Mentis Life Science Corp
Prostate Cancer
68Ga-PSMA PET/CT in Prostate Cancer
This is a single-center, multi-arm, open-label, phase III trial in up to 500 patients with biopsy-proven prostate cancer. Participants will receive regular standard of clinical care.
- Trial name
- NCT04684628
- Testing
- 68Ga-PSMA PET/CT
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Saskatchewan
Glioblastoma Multiforme
Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma
ICT-107 consists of dendritic cells, prepared from autologous mononuclear cells that are pulsed with six synthetic peptides that were derived from tumor associated antigens (TAA) present on glioblastoma tumor cells.
- Trial name
- NCT02546102
- Testing
- ICT-107
- Where
- 65 sites in United States, Austria and 1 more
- Volunteers
- 234 people
- Sponsor
- Precision Life Sciences Group