Clinical trials: suspended, in Canada
Cholangiopancreatography, Endoscopic Retrograde, Biliary Tract Diseases
Fistulotomy as the Primary Cannulation Technique for All Patients Undergoing ERCP: A Randomized, Controlled Trial
Participants in this study will be undergoing a procedure called an endoscopic retrograde cholangiopancreatography (ERCP). This procedure is most commonly performed to help treat conditions affecting specific areas of the…
- Trial name
- NCT04559867
- Testing
- Needle knife fistulotomy, Sphincterotomy
- Where
- Canada
- Volunteers
- 538 people
- Sponsor
- Lawrence Charles Hookey
COPD
Home Non-Invasive Ventilation Targeting Expiratory Flow Limitation in Severe Hypercapnic COPD.
In this 2-phase pilot study, the BiPAP A40 EFL will be evaluated in patients with severe COPD requiring home non-invasive ventilatory support with respect to patient-related and physiologic outcomes.
- Trial name
- NCT05109754
- Testing
- BiPAP EFL
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Lung Cancer
Radio-Immuno-Modulation in Lung Cancer
This project will assess the feasibility of treating advanced cancer using the immune system, without any anti-cancer drug. In this pilot study, the investigators propose combining low-dose radiotherapy, in lung cancer patients…
- Trial name
- RIM (NCT02579005)
- Testing
- Patients with a living donor, Patients with a UCB donor
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Pouchitis, Ulcerative Colitis
Assessment of Patients With Acute Pouchitis Treated With Antibiotics
The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy…
- Trial name
- NCT05252273
- Testing
- Observational, No intervention
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 43 people
- Sponsor
- Alimentiv Inc.
Chronic Pain
Pharmacogenetic Testing and Chronic Pain
Understanding the impact of genetics could aid rational, precision drug choices. In the current study, investigators will focus on whether genetic analysis of drug processing using the Inagene platform could predict efficacy and…
- Trial name
- NCT05259865
- Testing
- Genetic test for drug response prediction
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Phrenic Nerve Paralysis
Incidence of Hemidiaphragmatic Palsy After Interscalene Block
Primary objective of this study is to find out the incidence of hemi-diaphragmatic palsy associated with interscalene block done under ultrasound guidance.
- Trial name
- NCT01784601
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depressive Disorder, Major, Bipolar Depression
Ketamine Versus Electroconvulsive Therapy in Depression
While there are effective treatments for depression available, some patients do not see results with these options. Often, these patients are referred to electroconvulsive therapy (ECT) which has drawbacks such as adverse side…
- Trial name
- NCT03674671
- Testing
- Intravenous Ketamine, Electroconvulsive Therapy
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Chronic Pain
Adverse Childhood Events Chronic Pain
There is data to suggest that early childhood physical, emotional and sexual trauma could contribute to the development of chronic pain later in life, but this has not been studied in the Canadian Forces.
- Trial name
- NCT05259878
- Testing
- Adverse Childhood Events
- Where
- 2 sites in Canada
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Head and Neck Cancer
MRG FU With Radiotherapy for Palliation of H&N Cancer
Head and neck cancer is the sixth most common form of malignancy world-wide. Surgery, chemotherapy and radiation are associated with a high burden of side effects; tumour recurrence within the neck continues to be a major cause…
- Trial name
- NCT03218475
- Testing
- MR Guided Focused Ultrasound
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes Mellitus, Type 2
Investigational Study of Delayed Release Metformin
In Phase 1 and 2 studies already conducted, Metformin DR, with its targeted delivery to the distal small intestine, has shown the potential to be a safe and effective way to improve glycemic control in patients with T2DM and CKD…
- Trial name
- DREAM-T2D (NCT04854512)
- Testing
- Metformin DR, Metformin IR
- Where
- 87 sites in United States, Brazil and 6 more
- Volunteers
- 675 people
- Sponsor
- Anji Pharma
Sleep Apnea, Hypersomnia
Patient Outcomes in Unattended and In- Lab Polysomnography
This randomized controlled study will directly evaluate whether unattended polysomnography (level 2 sleep study) in individuals referred for sleep apnea or hypersomnia, including those with comorbidities of insomnia and…
- Trial name
- NCT05230394
- Testing
- Attended Polysomnography in the Lab, Unattended Polysomnography in the Home
- Where
- Canada
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Cerebra Medical
Alzheimer Disease
Neuro RX Gamma - Pivotal Phase
The active Neuro RX Gamma device uses non-invasive near-infrared energy delivered to the brain with the intention to improve cognitive functioning and quality of life in patients with moderate to severe Alzheimer's Disease.
- Trial name
- NCT03484143
- Testing
- Active Neuro RX Gamma device
- Where
- 9 sites in United States, Canada
- Volunteers
- 228 people
- Sponsor
- Vielight Inc.
Alzheimer Disease
A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and efficacy of GV-971 in mild to moderate Alzheimer's disease.
- Trial name
- GREEN MEMORY (NCT04520412)
- Testing
- GV-971
- Where
- 171 sites in United States, Australia and 8 more
- Volunteers
- 2,046 people
- Sponsor
- Green Valley (Shanghai) Pharmaceuticals Co., Ltd.
Infection
Effectiveness of Fecal Flora Alteration for Eradication of Carbapenemase-producing Enterobacteriaceae Colonization
Carbapenemase-producing Enterobacteriaceae (CPE) are bacteria carried in the gastrointestinal tract that are resistant to carbapenems, antibiotics of last resort. CPE infections result in death in 25-50% of cases.
- Trial name
- EFFECT-CPE (NCT03802461)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- 13 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Susy Hota
Anxiety, Anxiety Disorders
Prazosin Use in Adults With Anxiety Disorders
Prazosin has shown effectiveness in treating Post-Traumatic Stress Disorder through improving sleep quality and global functioning.
- Trial name
- NCT03894345
- Testing
- Prazosin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Abortion in First Trimester
Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion
A therapeutic abortion is one of the most common procedures performed in Canada, with approximately 100,000 occurring annually. 95% of induced abortions are done surgically, with just over two thirds of these procedures taking…
- Trial name
- NCT03751423
- Testing
- PO Morphine, IV Fentanyl, IV Ketamine
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Dr. Marie Eve Sophie Bussiere-Cote
Delirium, Dementia
The Prevention Program for Alzheimer's Related Delirium (PREPARED) Trial
By the year 2038, over a million Canadians are expected to have Alzheimer's disease, a type of dementia. Dementia increases the risk of nursing home placement among the elderly more than fivefold.
- Trial name
- PREPARED (NCT03718156)
- Testing
- PREPARED Trial Intervention
- Where
- 6 sites in Canada
- Volunteers
- 800 people
- Sponsor
- McGill University
Exostoses, Multiple Hereditary
Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project
The investigator's goal for this project is to examine the causes of the wide variability of the expression of Hereditary Multiple Exostoses (HME).
- Trial name
- NCT00474331
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Myocardial Infarction
Early Versus Standard Access Cardiac Rehabilitation to Counter Ventricular Remodeling Post-MI (EVADE)
BACKGROUND: Cardiac rehabilitation (CR) is an outpatient chronic disease management program delivering secondary prevention, which is proven to reduce morbidity and mortality.
- Trial name
- EVADE (NCT03534817)
- Testing
- Early Access CR
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Mild Cognitive Impairment
Magnetic Brain Stimulation in the Treatment of Mild Cognitive Impairment
This is a pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rTMS) on cognitive improvement in individuals with mild cognitive impairment (MCI).
- Trial name
- NCT02420522
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Manitoba