Clinical trials: in Chile
Prostatic Neoplasms
Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)
The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and docetaxel in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received…
- Trial name
- NCT03834506
- Testing
- Pembrolizumab, Docetaxel, Prednisone
- Where
- 215 sites in United States, Argentina and 19 more
- Volunteers
- 1,030 people
- Sponsor
- Merck Sharp & Dohme LLC
Nonalcoholic Steatohepatitis
A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001)
This study will evaluate the effect of each dose of MK-3655 versus placebo on the percentage of individuals with NASH resolution without worsening of fibrosis after 52 weeks.
- Trial name
- NCT04583423
- Testing
- MK-3655
- Where
- 180 sites in United States, Argentina and 22 more
- Volunteers
- 183 people
- Sponsor
- Merck Sharp & Dohme LLC
Myelofibrosis (MF)
Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis
Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body. MF disturbs the body's normal production of blood cells, causing extensive scarring in the bone marrow.
- Trial name
- NCT04454658
- Testing
- ABBV-744, Navitoclax, Ruxolitinib
- Where
- 43 sites in United States, Argentina and 12 more
- Volunteers
- 21 people
- Sponsor
- AbbVie
Neoplasms, Breast
Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease
This study will assess the efficacy and safety of Niraparib in participants with either tumor mutation in the BRCA gene (tBRCAmut) HER2- breast cancer (Independent of hormone receptor [HR] status, including HR positive [+] and…
- Trial name
- ZEST (NCT04915755)
- Testing
- Niraparib
- Where
- 198 sites in United States, Argentina and 25 more
- Volunteers
- 40 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
A Study to Evaluate SAR441566 Efficacy and Safety in Adults With Rheumatoid Arthritis
This is a parallel group, Phase 2, randomized, double-blind, placebo controlled, 5-arm, international, multicenter, 12-week proof of concept, dose finding study.
- Trial name
- SPECIFI-RA (NCT06073093)
- Testing
- SAR441566
- Where
- 102 sites in United States, Argentina and 17 more
- Volunteers
- 264 people
- Sponsor
- Sanofi
Healthy Aging, Lifestyle-related Condition
Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity
The prevalence of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is mounting worldwide, reaching pandemic proportions.
- Conditions
- Healthy Aging, Lifestyle-related Condition, Metabolic Diseases
- Trial name
- RESTORENAD (NCT06425042)
- Testing
- Nicotinamide Riboside (NR)
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Finis Terrae University
Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease in Patients With Rheumatoid Arthritis
Physical Exercise Program for Adults With Diffuse Interstitial Lung Disease in a Pulmonary Rehabilitation Context
This study aims to evaluate the effectiveness of an exercise program that includes three exercise modalities (Aerobic, Limb Strength and Respiratory Muscle Strength) versus an exercise program that includes only one modality…
- Conditions
- Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease in Patients With Rheumatoid Arthritis, Pulmonary Fibrosis
- Trial name
- NCT07061873
- Testing
- Aerobic excersise, Muscle strength limbs, inspiratory muscle strength
- Where
- Chile
- Volunteers
- 29 people
- Sponsor
- Universidad de La Frontera
Cardiovascular Disease Risk Factor, Insulin Resistance
Acute Postprandial Effects of Functional Ice Cream With Cimarrón Bean Extrudate in Adults
The goal of this non-randomized clinical trial is to evaluate the acute postprandial metabolic effects of a functional ice cream enriched with Cimarrón bean (Phaseolus vulgaris L.
- Conditions
- Cardiovascular Disease Risk Factor, Insulin Resistance, Overweight (BMI > 25), Hyperglycaemia
- Trial name
- ICE-CBE-GLULIP (NCT07053267)
- Testing
- Funrional Ice Cream
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Talca
Periodontitis, Peri-implantitis
Elucidating the Role of STAT3 in Epithelial-microbiome Interaction During Periodontitis and Peri-implantitis
Periodontitis and peri-implantitis are highly prevalent immuno-inflammatory pathologies, characterized by a series of intracellular signals, which, as a consequence of the interaction of the gingival epithelium with the dysbiotic…
- Trial name
- STAT3EpPPi (NCT07055256)
- Where
- Chile
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Chile
Mental Health Issue, Development, Child
Development, Usability and Feasibility Pilot Study of a Videogame
Mental health disorders are one of the leading causes of illness globally. The importance of psychosocial skills acquired in early childhood, such as executive functions, inhibitory control, emotional regulation, and social…
- Conditions
- Mental Health Issue, Development, Child, Cognitive Ability, General
- Trial name
- Japi-1 (NCT07048119)
- Testing
- Japi 1.0
- Where
- Chile
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Relapsing Multiple Sclerosis
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 2)
Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary…
- Trial name
- GEMINI 2 (NCT04410991)
- Testing
- Tolebrutinib, Teriflunomide HMR1726
- Where
- 186 sites in United States, Argentina and 26 more
- Volunteers
- 899 people
- Sponsor
- Sanofi
Symptomatic Aortic Stenosis
Pivotal Study of the Vienna Transcatheter Self Expandable Aortic Valve SE System
This is a prospective, single arm, multicenter study in an cohort of up to 267 patients (up to 100 Roll-ins and 167 patients implanted per protocol) symptomatic patients with severe aortic stenosis who will be followed up for up…
- Trial name
- VIVA (NCT04861805)
- Testing
- Vienna Aortic Valve SE System
- Where
- 31 sites in Argentina, Brazil and 6 more
- Volunteers
- 267 people
- Sponsor
- P+F Products + Features GmbH
Suicidal Ideation, Depression
Exploring the Effectiveness of a Suicide Ideation Prevention Program: Reframe-IT+
Suicide is a leading cause of death among young people, with worldwide prevalence rates of suicidal ideation, suicidal ideation with a plan, and suicide attempts in youth aged 14-21 years.
- Conditions
- Suicidal Ideation, Depression, Anxiety, Hopelessness
- Trial name
- Reframe-It+ (NCT06759441)
- Testing
- Reframe-It+
- Where
- Chile
- Volunteers
- 75 people
- Sponsor
- Universidad de los Andes, Chile
Neoplasms
A Study of MK-0482 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-0482-001)
This is a 2 part study. Part 1 is a dose escalation to determine the safety and tolerability and to establish a preliminary recommended Phase 2 dose (RP2D) dose of MK-0482 administered as monotherapy and in combination with…
- Trial name
- NCT03918278
- Testing
- MK-0482, pembrolizumab, Paclitaxel
- Where
- 16 sites in United States, Australia and 6 more
- Volunteers
- 222 people
- Sponsor
- Merck Sharp & Dohme LLC
Non-carious Cervical Lesions
Effect of Wet and Overwet Dentin on the Clinical Performance of Two Universal Adhesive Systems
The aim of this study will be to evaluate the effect of wet and overwet dentin on the long-term clinical performance of two universal adhesive systems used as etch-and-rinse application mode in non-carious cervical lesions…
- Trial name
- NCT07034235
- Testing
- Dentin Wet, Dentin Overwet, Ambar Universal APS Plus; FGM
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Dialysis; Complications, Performance Enhancing Product Use
Effects of Short Term Creatine Supplementation in Hemodialysis Patients
Adult patients undergoing chronic dialysis therapy for at least three months were selected. A physical function assessment was conducted, including the Short Physical Performance Battery (SPPB) and a handgrip strength test.
- Trial name
- NCT07033611
- Testing
- Creatine
- Where
- Chile
- Volunteers
- 18 people
- Sponsor
- Carla Basualto Alarcón
Healthy Children
Physical Activity Intervention
Obesity is a problem that affects almost every region of the world. In Chile, data indicate that the prevalence of obesity in preschool children aged 4 to 6 years is 58%, which increases as they reach adolescence and adulthood.
- Trial name
- NCT07029685
- Testing
- Physical
- Where
- Chile
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Andrés Godoy Cumillaf
the Transection of Tissues, the Resection of Tissues
Post-Market Clinical Follow-Up Study Plan for Cartridges of Disposable Endoscopic Linear Cutting Staplers
Cartridges of Disposable Endoscopic Linear Cutting Staplers, Disposable Powered Endoscopic Linear Cutting Staplers and Disposable Endoscopic Linear Cutting Staplers manufactured by Ningbo Verykind Medical Device Co., Ltd.
- Conditions
- the Transection of Tissues, the Resection of Tissues, the Creation of Anastomoses
- Trial name
- NCT07028554
- Testing
- Cartridges of Disposable Endoscopic Linear Cutting Staplers, Disposable Powered
- Where
- Chile
- Volunteers
- 300 people
- Sponsor
- Suzhou Care-Real Medical Technology Co., Ltd.
Risk of Falls
Active Exergames Program in Older Adults at Risk of Falls
The goal of this randomized clinical trial is to analyze the effectiveness of a physical exercise program based on exergames combined with conventional physical therapy, compared to a conventional physical exercise program alone…
- Trial name
- NCT07024004
- Testing
- Exergame-Based Exercise + Conventional Physical Therapy, Conventional Physical Therapy
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Universidad Catolica Silva Henriquez
Advanced Solid Tumors
A Study of BMS-986360/CC-90001 Alone and in Combination With Chemotherapy or Nivolumab in Advanced Solid Tumors
The aim of this study is to assess the safety and tolerability of BMS-986360 as monotherapy and in combination with chemotherapy or nivolumab in participants with advanced solid tumors.
- Trial name
- NCT05625412
- Testing
- BMS-986360, Docetaxel, Nivolumab
- Where
- 35 sites in United States, Argentina and 7 more
- Volunteers
- 70 people
- Sponsor
- Bristol-Myers Squibb