Clinical trials: in Croatia
COVID-19
A Study Evaluating Tocilizumab in Pediatric Patients Hospitalized With COVID-19
This is a single-arm, open-label study to assess the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of tocilizumab (TCZ) for the treatment of pediatric patients from birth to less than 18 years old…
- Trial name
- NCT05164133
- Testing
- Tocilizumab
- Where
- 25 sites in United States, Brazil and 9 more
- Volunteers
- 2 people
- Sponsor
- Hoffmann-La Roche
Muscular Atrophy, Spinal
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants
Multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of Risdiplam in adult and pediatric participants with Type 2 and Type 3 SMA.
- Trial name
- SUNFISH (NCT02908685)
- Testing
- Risdiplam
- Where
- 45 sites in United States, Belgium and 14 more
- Volunteers
- 231 people
- Sponsor
- Hoffmann-La Roche
Metastatic Colorectal Cancer
Management of Metastatic Colorectal Cancer: A Clinical and Patient Perspective
A Real World Evidence Prospective Cohort Study in the Management of Metastatic Colorectal Cancer: A Clinical and Patient Perspective
- Trial name
- PROMETCO (NCT03935763)
- Testing
- observational disease study
- Where
- 18 sites in Argentina, Austria and 16 more
- Volunteers
- 738 people
- Sponsor
- Servier Affaires Médicales
Alcohol Use Disorder
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms
Randomized, multi-center, double-blind, parallel-group, placebo-controlled study. Eligible subjects will be randomized to receive either 0.33 mg AD04 or placebo orally twice-daily for 24 weeks in conjunction with brief…
- Trial name
- ONWARD (NCT04101227)
- Testing
- AD04 (ondansetron), Companion Diagnostic for Genetic Testing, Brief Psychological Counseling
- Where
- 25 sites in Bulgaria, Croatia and 5 more
- Volunteers
- 302 people
- Sponsor
- Adial Pharmaceuticals
Inflammatory Bowel Diseases, Crohns Disease
A Study on Administration Choices of Vedolizumab and Outcomes for Adults With Inflammatory Bowel Disease (IBD) (VARIETY - CROATIA AND SLOVENIA)
Inflammatory bowel disease consists of either ulcerative colitis (UC) or Crohn's disease (CD). The main aim of this study is to describe real-world treatment patterns in adults with moderate to severe ulcerative colitis or…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Colitis, Ulcerative
- Trial name
- NCT04885920
- Where
- 8 sites in Croatia, Slovenia
- Volunteers
- 120 people
- Sponsor
- Takeda
Incisional Ventral Hernia, Recurrent Ventral Hernia
Modified "Open Intraperitoneal Mesh" Technique of Incisional Ventral Hernia Repair
Ventral hernias, primary and recurrent, are major surgical challenge. We aim to investigate efficacy of modified technique of ventral hernias repair: an "open intraperitoneal mesh" technique.
- Trial name
- NCT01953302
- Testing
- modified "open mesh technique"
- Where
- Croatia
- Volunteers
- 124 people
- Sponsor
- Varazdin General Hospital
HIV, Hepatitis B
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study is a prospective observational cohort study of 23,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina.
- Conditions
- HIV, Hepatitis B, Hepatitis C, AIDS
- Trial name
- EuroSIDA (NCT02699736)
- Where
- 110 sites in Argentina, Austria and 34 more
- Volunteers
- 23,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adenoid Vegetation
Adenoid Vegetations in Adult Patients
In this observational cross-sectional study " the clinical characteristics of adenoid vegetations in adulthood will be investigated.
- Trial name
- NCT06041074
- Where
- Croatia
- Volunteers
- 161 people
- Sponsor
- Varazdin General Hospital
Multiple Sclerosis
Orofacial Pain in Multiple Sclerosis
Although the orofacial pain is not typical symptom of multiple sclerosis, more than 50% of the patients experience some kind of pain.
- Trial name
- NCT06021561
- Testing
- Diagnosis of pain
- Where
- Croatia
- Sponsor
- Varazdin General Hospital
Trigeminal Neuralgia
Analgesic Effect of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia
This is a study about the dynamics and effects of ultrasound guided maxillary nerve block in trigeminal neuralgia
- Trial name
- NCT06129071
- Testing
- US guided block of maxillary nerve
- Where
- Croatia
- Sponsor
- Varazdin General Hospital
Urinary Tract Cancer
A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
This Phase IIIb, multicenter study will assess the safety of atezolizumab as second- to fourth-line treatment for participants with locally advanced or metastatic urothelial or non-urothelial cancer of the urinary tract in…
- Trial name
- NCT02928406
- Testing
- Atezolizumab
- Where
- 175 sites in Argentina, Australia and 30 more
- Volunteers
- 1,004 people
- Sponsor
- Hoffmann-La Roche
Molar, Impacted Teeth
Analgesic Effects of Extraoral Ultrasound Block of Mandibular Nerve for the Extraction of Lower Third Molars
This is a study about the dynamics and effects of different types of blocks (intraoral conduction anesthesia of the alveolar nerve and extraoral US block of the mandibular nerve) for extraction of lower third molars.
- Trial name
- NCT06009302
- Testing
- US guided block of mandibular nerve, Intraoral block of lower alveolar nerve
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- Varazdin General Hospital
Colorectal Cancer, Behavior Change
Using Behavioural and Cultural Insights to Increase Colorectal Cancer Home-testing in Croatia
Colorectal cancer (CRC) is one of the leading causes of death in Croatia. An average of 3600 cases are diagnosed and an average of 2100 people die from the disease every year.
- Trial name
- NCT06341322
- Testing
- Standard letter, Behaviorally informed letter, Home testing colorectal cancer kit
- Where
- Croatia
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Veerle Snijders
Heart Failure
Sacubitril/Valsartan in Left Ventricular Assist Device Recipients
The primary objective of this prospective randomised study is to assess the safety and tolerability of sacubitril/valsartan compared with standard of care used for treating BP in patients that have been implanted with the Heart…
- Trial name
- ENVAD-HF (NCT04103554)
- Testing
- Sacubitril-Valsartan, Standard of care
- Where
- 6 sites in Croatia, Czechia and 2 more
- Volunteers
- 60 people
- Sponsor
- University of Zagreb
IgA Nephropathy, IgAN
Safety and Efficacy of AT-1501 in Patients With IgA Nephropathy (IgAN)
This is a phase 2a, multicenter, open-label study designed to evaluate the safety and efficacy of AT-1501 in patients with biopsy proven IgAN and at least 0.75 g/24 hours of protein in their urine at the time of screening.
- Trial name
- NCT05125068
- Testing
- AT-1501
- Where
- 26 sites in Australia, Croatia and 8 more
- Volunteers
- 24 people
- Sponsor
- Eledon Pharmaceuticals
Contact Dermatitis
Assessment of Niacinamide Cosmetic Product Efficacy in Model of Irritant Contact Dermatitis
Testing the effectiveness and safety of cosmetics with niacinamide in irritant contact dermatitis: A Randomised, Controlled Trial will be conducted at USSM.
- Trial name
- NCT06331390
- Testing
- niacinamide cosmetic product
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Gingival Recession
Effectiveness of Hyaluronic Acid on Multiple Adjacent Gingival Recessions Using a Coronally Advanced Flap
The goal of this clinical randomized trial is to examine the effectiveness of hyaluronic acid in treatment of multiple adjacent gingival recessions in 2 groups.
- Trial name
- NCT06330662
- Testing
- Testing the effectiveness of hyaluronic acid in experimental group using a coronally advanced flap compared to a control group using a coronally advanced flap only
- Where
- Croatia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Andelina Sekelja
Triple-Negative Breast Cancer
A Study of Atezolizumab and Paclitaxel Versus Placebo and Paclitaxel in Participants With Previously Untreated Locally Advanced or Metastatic Triple Negative Breast Cancer (TNBC)
This Phase 3, multicenter, randomized, double-blind, placebo controlled study is designed to evaluate the efficacy and safety of atezolizumab (MPDL3280A, an anti-programmed death-ligand 1 [PD-L1] antibody) administered in…
- Trial name
- IMpassion131 (NCT03125902)
- Testing
- Atezolizumab (MPDL3280A), an engineered anti-PDL1 antibody, Paclitaxel
- Where
- 161 sites in United States, Argentina and 22 more
- Volunteers
- 653 people
- Sponsor
- Hoffmann-La Roche
Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
Registry on Hypomethylating Agents in Myeloid Neoplasms
This registry is set up to collect real-world experience in the management of patients with myeloid neoplasms, in particularly in patients with MDS, CMML or AML, treated with hypomethylating agents in Austria and potentially…
- Conditions
- Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes, Acute Myeloid Leukemia
- Trial name
- NCT01595295
- Testing
- non interventional
- Where
- 20 sites in Austria, Croatia
- Volunteers
- 1,500 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Minimally Invasive Surgery
RCT on 3 Types of Hysterectomy
A randomized controlled trial comparing the vaginal, vNOTES ( vaginal natural orifice transluminal surgery) or laparoscopic approach for hysterectomy in women with benign gynaecological disease
- Trial name
- VANOLAH (NCT05971875)
- Testing
- vNOTES vs Vaginal Hysterectomy, vNOTES vs Laparoscopic Hysterectomy
- Where
- 2 sites in Croatia, Sweden
- Volunteers
- 1,000 people
- Sponsor
- Dr Jan Baekelandt, MD
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