Clinical trials: in Croatia
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation From a Haploidentical Family Donor Compared to Post-transplant Cyclophosphamide in Patients With Blood Cancer
The primary objective of this study is to compare safety and efficacy of a haploidentical T-cell depleted HSCT and adjunctive treatment with ATIR101 versus a haploidentical T cell replete HSCT with post-transplant administration…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome
- Trial name
- HATCY (NCT02999854)
- Testing
- ATIR101, Cyclophosphamide, T-cell depleted HSCT from a related, haploidentical donor
- Where
- 42 sites in United States, Belgium and 11 more
- Volunteers
- 63 people
- Sponsor
- Kiadis Pharma
Colorectal Cancer
The Anti-inflammatory Effect of Anesthetics in Abdominal Surgery
Clinical studies have shown that IV administration of anesthetics, lidocaine and ketamine with their anti-inflammatory properties, modulates the acute immune response associated with surgical tissue injury, and in this manner…
- Trial name
- NCT03821545
- Testing
- Lidocaine, Ketamine, Lidocaine and Ketamine
- Where
- Croatia
- Volunteers
- 82 people
- Sponsor
- University Hospital Dubrava
Cystoid Macular Edema Following Cataract Surgery
PCME Prevention in Patients With NPDR
Pseudophakic cystoid macular edema (PCME), or Irvine-Gass syndrome, is retinal thickening of the macula, which usually develops within 3 months after surgery, with a peak incidence between 4 and 6 weeks.
- Trial name
- NCT04940338
- Testing
- Bromfenac Ophthalmic 0.09% Ophthalmic Solution, Dexamethasone Ophthalmic, Phacoemulsification surgery (PHACO)
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Covid-19, Respiratory Distress Syndrome
Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients
Single center, open label randomized clinical trial. Study location: tertiary hospital center (University Hospital Split, Croatia).
- Conditions
- Covid-19, Respiratory Distress Syndrome, Vitamin D Deficiency
- Trial name
- NCT05384574
- Testing
- cholecalciferol
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University Hospital of Split
Schizophrenia
TMS in Treatment of Schizophrenia Negative Symptoms
Primary objective: to examine the efficacy and safety of high frequency repetitive transcranial magnetic stimulation (HF rTMS) with H7-coil applied once daily during the twenty days, augmentative to the standard antipsychotic…
- Trial name
- NCT04268797
- Testing
- HR rTMS
- Where
- Croatia
- Volunteers
- 104 people
- Sponsor
- Sveti Ivan Psychiatric Hospital
Post-ERCP Acute Pancreatitis
ERCP-induced and Non-ERCP Induced Acute Pancreatitis: Two Distinct Clinical and Immunological Entities?
Post endoscopic pancreatitis (PEP) has different initial immunologic response to primary injury compared to acute pancreatitis of other etiology (non-PEP AP).
- Trial name
- NCT02602574
- Testing
- heparinized peripheral venous blood and urine sample.
- Where
- Croatia
- Volunteers
- 66 people
- Sponsor
- University Hospital Rijeka
Pulmonary Arterial Hypertension
Effects of Oral Sildenafil on Mortality in Adults With PAH
This is a blinded study in adult patients with PAH evaluating the relative effects of sildenafil on mortality when administered at the three doses (80 mg, 20 mg or 5 mg, all three times per day [TID]).
- Trial name
- AFFILIATE (NCT02060487)
- Testing
- sildenafil citrate
- Where
- 82 sites in United States, Australia and 21 more
- Volunteers
- 385 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Orthodontic Relapse
Efficacy and Cost-effectiveness of Orthodontic Retention Protocols
Objective is to assess changes of dentition and periodontium, and hygiene in retention after the end of the active phase of orthodontic treatment, and relationship with gender, type of retention appliance, pre-therapeutic…
- Trial name
- orthoretenti (NCT05121220)
- Testing
- fixed retainer, removable retainer
- Where
- Croatia
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Poliklinika Orthonova
Paroxysmal Atrial Fibrillation
PEFCATII Expanded Safety and Feasibility Study of the FARAPULSE Endocardial Multi Ablation System to Treat Paroxysmal Atrial Fibrillation
PEFCAT II: Expanded Safety and Feasibility Study of the FARAPULSE Endocardial Multi Ablation System to Treat Paroxysmal Atrial Fibrillation
- Trial name
- PEFCATII (NCT04170608)
- Testing
- FARAPULSE Endocardial Multi Ablation System
- Where
- 2 sites in Croatia, Czechia
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Arrhythmias
Study Evaluating GAP-486 in Non-sustained Ventricular Tachycardia
To determine whether the administration of test article will decrease the occurrence of ventricular arrhythmias in patients who have acute coronary syndrome (unstable angina, ST segment elevated myocardial infarction or…
- Trial name
- NCT00124891
- Testing
- Double-blind investigational anti-arrhythmic, GAP-486
- Where
- 75 sites in United States, Brazil and 14 more
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Myelofibrosis, Acute Myelogenous Leukemia
Safety and Early Efficacy Study of TBX-2400 in Patients With AML or Myelofibrosis
This is a study of allogeneic stem cell transplantation with TBX-2400 in adult subjects with Acute Myelogenous Leukemia (AML) or Myelofibrosis (MF).
- Trial name
- NCT04709458
- Testing
- TBX-2400
- Where
- 2 sites in Croatia, Italy
- Volunteers
- 10 people
- Sponsor
- Taiga Biotechnologies, Inc.
Rheumatoid Arthritis
An Extension Study in Participants With Moderate to Severe Rheumatoid Arthritis
The purpose of this study is to investigate the long-term safety and any side effects of baricitinib in participants who have completed a previous baricitinib rheumatoid arthritis study.
- Trial name
- RA-BEYOND (NCT01885078)
- Testing
- Baricitinib
- Where
- 408 sites in United States, Argentina and 36 more
- Volunteers
- 2,877 people
- Sponsor
- Eli Lilly and Company
Multiple Sclerosis
BRAVO Study: Laquinimod Double-blind Placebo-controlled Study in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS) With a Rater Blinded Reference Arm of Interferon β-1a (Avonex®)
The study aims to compare the effect of daily oral treatment of laquinimod capsules 0.6 milligrams (mg) with the effect of placebo capsules (capsules that contain no active medication) as well as with the effect of an existing…
- Trial name
- BRAVO (NCT00605215)
- Testing
- Laquinimod, Avonex®
- Where
- 170 sites in United States, Bulgaria and 17 more
- Volunteers
- 1,331 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Anesthesia, Anesthesia Complication
Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
Light to moderate sedation is recommended during surgery with spinal anesthesia . This study is exploring which sedation drug is better, midazolam or dexmedetomidine for transurethral resection of bladder and prostate in patients…
- Conditions
- Anesthesia, Anesthesia Complication, Osa Syndrome, Transurethral Resection of Prostate
- Trial name
- NCT04817033
- Testing
- Spinal anesthesia with intraoperative dexmedetomidine sedation, Spinal anesthesia with intraoperative midazolam sedation, Dexmedetomidine
- Where
- Croatia
- Volunteers
- 115 people
- Sponsor
- University Hospital of Split
Painful Diabetic Peripheral Neuropathy
Efficacy of Pregabalin and Duloxetine in Patients With PDPN: the Effect of Pain on Cognitive Function, Sleep and Quality of Life
The objective and the purpose of the trial is to: assess the efficacy of Pregabalin Krka and Dulsevia® in patients with PDPN, investigate the effect of Pregabalin Krka and Dulsevia® on pain and on quality of life (QOL)…
- Trial name
- BLOSSOM (NCT04246619)
- Testing
- Pregabalin, Duloxetine
- Where
- 13 sites in Croatia, North Macedonia and 3 more
- Volunteers
- 254 people
- Sponsor
- KRKA
Appendicitis Acute
Diagnostic Importance of the Circulating Human Leucine-rich α-2-glycoprotein in Acute Appendicitis in Pediatric Patients
Acute appendicitis is a common and potentially serious medical condition which can be difficult to diagnose, especially in pediatric patients.
- Trial name
- NCT05093660
- Testing
- Blood specimen collection, Saliva specimen collection
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- KBC Split
Adverse Reaction to Vaccine, COVID19 Vaccine
COVID-19 Vaccines Safety Tracking (CoVaST)
This project aims to monitor the side effects of COVID-19 vaccines worldwide actively. The primary objectives of the project include a) to estimate the prevalence of each local and systemic side effect of each COVID-19 vaccine…
- Trial name
- NCT04834869
- Testing
- BNT162b2, mRNA-1273, AZD1222
- Where
- 14 sites in United States, Canada and 12 more
- Volunteers
- 30,000 people
- Sponsor
- Masaryk University
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Breast Cancer
A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Who Have Received Prior Anti-HER2 And Chemotherapy-based Treatment
This two-cohort, open-label, multicenter study will assess the safety, efficacy and tolerability of trastuzumab emtansine in participants with HER2-positive locally advanced breast cancer (LABC) or metastatic breast cancer (mBC)…
- Trial name
- NCT01702571
- Testing
- Trastuzumab Emtansine
- Where
- 300 sites in Argentina, Australia and 41 more
- Volunteers
- 2,185 people
- Sponsor
- Hoffmann-La Roche
Pharmacogenetics, Drug-Related Side Effects and Adverse Reactions
Pharmacogenomics in Prediction of Cardiovascular Drugs Adverse Reaction
The research is planned as a prospective nested case-control study. The plan is to recruit about 1,200 consecutive subjects whose pharmacotherapy involves the drug(s) of interest within 4.5 years.
- Conditions
- Pharmacogenetics, Drug-Related Side Effects and Adverse Reactions, Cardiovascular Drugs
- Trial name
- NCT05307718
- Testing
- Oral Anticoagulant, Direct-Acting
- Where
- Croatia
- Volunteers
- 1,200 people
- Sponsor
- Clinical Hospital Centre Zagreb
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