Clinical trials: in Croatia
Periodontitis, Gingivitis
Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis
Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples.
- Conditions
- Periodontitis, Gingivitis, Infertility
- Trial name
- NCT03542630
- Testing
- salivary MMP8 test, periodontal examination, blood tests
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Salt; Excess, Pregnancy Related
Dietary Salt During Pregnancy and Maternal Vascular Function
The main goal of this study is to investigate the association of dietary salt intake during pregnancy with systemic micro- and macrovascular reactivity and uteroplacental vascular function of the mother, and to examine the…
- Trial name
- NCT05048225
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Chemotherapy-Induced Nausea and Vomiting
An Efficacy and Safety Study of Oral and Intravenous Palonosetron for the Prevention of Nausea and Vomiting
PALO-10-01 is a clinical study assessing efficacy and safety of a single oral dose of palonosetron compared to a single intravenous dose of palonosetron (Aloxi, an antiemetic drug), both given with oral dexamethasone.
- Trial name
- NCT01363479
- Testing
- Oral palonosetron, I.V. palonosetron, Dexamethasone
- Where
- 79 sites in United States, Argentina and 10 more
- Volunteers
- 743 people
- Sponsor
- Helsinn Healthcare SA
NK Cell Mediated Immunity, NK Cell Cytokine Production
Cellular Immunity and Renal Cell Cancer
Renal cell cancer (RCC) is one of the most important urogenital tumors because of it's high mortality and increasing incidence. RCC, which accounts about 3% of all malignant tumors in the adults, is the most lethal urogenital…
- Conditions
- NK Cell Mediated Immunity, NK Cell Cytokine Production, Kidney Cancer
- Trial name
- NCT04377113
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Ulcerative Colitis
Long-Term Study Of CP-690,550 In Subjects With Ulcerative Colitis
This study is an open label, long-term extension study for subjects with moderate to severe ulcerative colitis designed to evaluate long term therapy of CP-690,550.
- Trial name
- OCTAVE (NCT01470612)
- Testing
- CP-690,550
- Where
- 252 sites in United States, Australia and 29 more
- Volunteers
- 944 people
- Sponsor
- Pfizer
Idiopathic Pulmonary Fibrosis
A Clinical Study to Test How Effective and Safe GLPG1205 is for Participants With Idiopathic Pulmonary Fibrosis (IPF)
This is a randomized, double-blind, parallel-group, placebo-controlled, multicenter, exploratory Phase 2 study including participants with Idiopathic Pulmonary Fibrosis (IPF), investigating GLPG1205 in addition to the local…
- Trial name
- PINTA (NCT03725852)
- Testing
- GLPG1205
- Where
- 36 sites in Bulgaria, Croatia and 7 more
- Volunteers
- 68 people
- Sponsor
- Lakefront Biotherapeutics NV
Spondyloarthritis
SKIPPAIN - Speed of Onset of SecuKinumab-Induced Relief From Pain in Patients With AxIal SpoNdyloarthritis
The purpose of the study was to evaluate the efficacy and safety of secukinumab 150 mg compared to placebo in the early management (Baseline to Week 8) of spinal pain, disease activity, fatigue, and predictability of disease…
- Trial name
- SKIPPAIN (NCT03136861)
- Testing
- AIN457
- Where
- 66 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 383 people
- Sponsor
- Novartis Pharmaceuticals
Varicocele, Postoperative Pain
The Effect of Subcutaneous and Intraperitoneal Anesthesia on Post Laparoscopic Pain
Aim of this study is to examine the effects of subcutaneously applied local anesthetics at trocar site in combination with intraoperative intraperitoneal analgesia on duration and character of pain in pediatric patients…
- Trial name
- NCT05034406
- Testing
- 2% Lidocaine, 0.5% levobupivacaine
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- KBC Split
Ulcerative Colitis
Safety and Efficacy Trial of RPC1063 for Moderate to Severe Ulcerative Colitis
The purpose of this study is to determine whether RPC1063 is effective in the treatment of Ulcerative Colitis (UC).
- Trial name
- NCT02435992
- Testing
- RPC1063
- Where
- 372 sites in United States, Argentina and 28 more
- Volunteers
- 1,012 people
- Sponsor
- Celgene
Spirometry, Qadriceps Muscle
The Effect of Orally Administered L- Arginine on Quadriceps Strenght in Healthy Smokers
The study will investigate changes in certain locomotor parameters as early predictors of disease in smokers who are prone to develop chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04643600
- Testing
- L-Arginine, 500 Mg Oral Capsule
- Where
- Croatia
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Goranka Radmilović
Diabetes Mellitus, Type 2, Coronary Artery Disease
Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
The purpose of this study is to determine whether bromodomain extraterminal domain (BET) inhibition treatment with RVX000222 in high-risk type 2 diabetes mellitus patients with coronary artery disease increases the time to major…
- Trial name
- BETonMACE (NCT02586155)
- Testing
- Apabetalone, Atorvastatin, Rosuvastatin
- Where
- 214 sites in Argentina, Australia and 13 more
- Volunteers
- 2,425 people
- Sponsor
- Resverlogix Corp
Graft-versus-host Disease, Acute-graft-versus-host Disease
An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD)
This is a study comparing the defibrotide prophylaxis arm vs standard of care arm for the prevention of aGvHD.
- Trial name
- NCT03339297
- Testing
- Defibrotide, Standard of Care
- Where
- 62 sites in United States, Austria and 12 more
- Volunteers
- 152 people
- Sponsor
- Jazz Pharmaceuticals
Parkinson Disease, Genetic Disease
The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK)
Parkinson's disease (PD) is the second most common neurodegenerative disease, which affects 2-3% of the general population above 65 years.
- Conditions
- Parkinson Disease, Genetic Disease, Microbiota, Neuro-Degenerative Disease
- Trial name
- GiOPARK (NCT05008094)
- Testing
- Whole-exome sequencing, Microbiota sequencing, Magnetic resonance imaging
- Where
- Croatia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Obesity, Weight Loss
Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients
Obesity manifest with inflammation, hyperglycaemia and dyslipidaemia. These conditions disturb redox system by generating excessive reactive oxygen species (ROS) and causing oxidative stress (OS) leading to DNA damage.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05007171
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 22 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Large-for-gestational-age Neonates, Glycemic Variability
Diabetes Type One in Pregnancy and Continuos Glucose Monitoring
Type I diabetes mellitus (T1DM) affects about 0.1-0.2% of all pregnancies. T1DM in pregnancy increases the risk of maternal and neonatal complications.
- Conditions
- Large-for-gestational-age Neonates, Glycemic Variability, Hypoglycemia, Pregnancy Outcomes
- Trial name
- DIP1/CRO (NCT04997460)
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Clinical Hospital Centre Zagreb
General Surgery
Inflammation and Postoperative Tramadol Analgesia
Patients will be admitted in the intensive care unit after major abdominal surgery. All patients will receive 100 mg of tramadol intravenously every 6 hours.
- Trial name
- NCT04330157
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Osijek University Hospital
Small Cell Lung Cancer
A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)
This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based chemotherapy.
- Trial name
- MERU (NCT03033511)
- Testing
- Rovalpituzumab tesirine, Dexamethasone
- Where
- 308 sites in United States, Australia and 39 more
- Volunteers
- 748 people
- Sponsor
- AbbVie
Ischemic Stroke
Prognostic Accuracy of ST2 Dynamics in Ischemic Stroke Outcome
Early outcome prediction after ischemic stroke (IS) is of great importance. Prognosis is usually based on clinical variables and neuroradiological findings while serum biomarkers may contribute to prognostic accuracy.
- Trial name
- ST2ROKE (NCT04607031)
- Testing
- measurement of serum ST2 concentrations in serum of patients with acute, ischemic stroke
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- General Hospital Sveti Duh
Hypertension
Olmesartan/HCTZ 40/12.5 mg Combination Therapy Versus Olmesartan Medoxomil 40 mg Monotherapy in Essential Hypertension
The primary objective of this study was to assess the anti-hypertensive effect of OM/HCTZ 40/12.5 mg combination therapy compared to OM 40 mg monotherapy in lowering sitting diastolic BP in hypertensive patients after 8 weeks of…
- Trial name
- NCT00441350
- Testing
- OM 40, OM/HCTZ 40/12.5
- Where
- 65 sites in Croatia, Czechia and 6 more
- Volunteers
- 1,004 people
- Sponsor
- Menarini Group
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