Clinical trials: open to volunteers, in Germany
Gastrointestinal Neoplasm Malignant
Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models
This study will evaluate the utility of ChatGPT in recommending treatment plans for patients with gastrointestinal cancers, using both retrospective and prospective data.
- Trial name
- NCT06002425
- Testing
- Clinician-Directed Treatment Plan, ChatGPT-Assisted Treatment Plan
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 400 people
- Sponsor
- Chinese Academy of Sciences
Heart Transplantation
Genomics in Heart Transplants
A cross-sectional analysis of 200 heart transplant recipients, combining in-depth phenotyping and risk factor assessment (cardiac MRI, coronary angiogram with OCT, cardiorespiratory exercise tests, exogenic factors like…
- Trial name
- NCT06012162
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
The aim of the prospective observational DISTEMI-Study in people with and without Diabetes mellitus (DI) after new onset of ST-Segment Elevation Myocardial Infarction (STEMI) aged 18-80 years at inclusion into the study is to…
- Conditions
- ST-segment Elevation Myocardial Infarction (STEMI), Diabetes Mellitus, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- DISTEMI (NCT05046483)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Munich ME/CFS Cohort Study
The Munich cohort study MUC-CFS aims at the characterization and long-term follow-up of myalgic encephalitis/chronic fatigue syndrome (ME/CFS) in young people aged up to 25 years, as well as at the identification of…
- Trial name
- MUC-CFS (NCT06005246)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Hyperthermia, Cancer
Prospective Hyperthermia Database in Cancer Patients (HT Register)
This monocentric study registry records all cancer patients at the Charité which are treated with hyperthermia to examine the therapeutic use of hyperthermia in cancer patients in the general application and to obtain an accurate…
- Trial name
- HTRegister (NCT05993910)
- Testing
- Hyperthermie Register
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Pirus Ghadjar
Arteriosclerosis, Acute Myocardial Infarction
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause.
- Conditions
- Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
- Trial name
- NCT05985447
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
MPS III B
Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE
This is a Phase 3B/4, multicenter, multinational, open label study to further evaluate intracerebroventricular (ICV) delivered AX 250 treatment in MPS IIIB subjects that complete Study 250-202 for up to an additional 3 years (144…
- Trial name
- NCT05492799
- Testing
- AX 250
- Where
- 6 sites in United States, Colombia and 3 more
- Volunteers
- 15 people
- Sponsor
- Allievex Corporation
Urinary Incontinence, Epispadias, Male
Autologous Muscle Stem Cell Therapy for Treatment of Congenital Urinary Incontinence in Epispadias Patients
The aim of this trial is to evaluate the safety and efficacy of an autologous muscle stem cell therapy in the treatment of congenital urinary incontinence in isolated epispadias.
- Trial name
- MUST (NCT04729582)
- Testing
- Primary human muscle stem cells (Satori-01)
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Simone Spuler, MD
Aortic Valve Disease, Cardiovascular Diseases
A Prospective Multicenter Pivotal Study to Evaluate Safety and Effectiveness of Venus-Neo Surgical Aortic Valve
The goal of this clinical trial is to evaluate the safety, effectiveness, and performance of Venus-Neo Surgical Aortic Valve in subjects who are clinically indicated for aortic valve replacement.
- Trial name
- METASAR (NCT05941455)
- Testing
- Venus-Neo Surgical Aortic Valve
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Jilin Venus Haoyue Medtech Limited
Severe Hemophilia A, Severe Hemophilia A With Inhibitor
Dynamics of the Anti-factor VIII Antibody Signature During Treatment With Emicizumab
The goal of this observational study is to learn about the changes of antibodies and inhibitors against the coagulation factor VIII in patients with severe hemophilia A receiving emicizumab therapy.
- Conditions
- Severe Hemophilia A, Severe Hemophilia A With Inhibitor, Severe Hemophilia A Without Inhibitor
- Trial name
- NAVIGATE (NCT05802836)
- Testing
- no interventions
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Christoph Königs
Carcinoma, Non-Small-Cell Lung
National Network Genomic Medicine Lung Cancer, Germany
Registry of the national Network Genomic Medicine Lung Cancer (nNGM), linking data on molecular diagnostics, clinical characteristics, treatment patterns and outcomes of subjects with non-small cell lung cancer (NSCLC) from 23…
- Trial name
- nNGM (NCT05934032)
- Testing
- observational, non-interventional
- Where
- Germany
- Volunteers
- 30,000 people
- Sponsor
- Prof. Dr. Juergen Wolf
Cancer
Prospective Observational Study of a Precision Medicine Approach in Patients With Advanced Cancer
Prospective observational study of a precision medicine approach in patients with advanced cancer. In this registrational study, patients with advanced cancer undergoing extensive molecular sequencing within the precision…
- Trial name
- PRIME (NCT05926284)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Charite University, Berlin, Germany
Arthritis, Juvenile Rheumatoid
Juvenile Inflammatory Rheumatism (JIR) Cohorte
The investigators created a cohort of patients with juvenile inflammatory rheumatisms with the purpose to follow them prospectively, and investigate the tolerance and efficacy of immunosuppresive and biological agents.
- Trial name
- JIR-cohorte (NCT02377245)
- Where
- 45 sites in Belgium, France and 3 more
- Volunteers
- 15,000 people
- Sponsor
- Michaël Hofer
Coronary Heart Disease
Clinical Value and Cost-effectiveness of a Personalized Prevention Program (PPP) in Patients With High Risk Stable CHD
Prospective clinical study with two parts: PART A: a prospective biomarker-based risk screening study in coronary heart disease (CHD) subjects PART B: a nested randomized clinical trial (RCT) in an enriched subpopulation of…
- Trial name
- NCT04433052
- Testing
- personalised prevention program (PPP)
- Where
- 26 sites in Finland, Germany and 4 more
- Volunteers
- 12,000 people
- Sponsor
- Tampere University
PDAC, Pancreatoduodenectomy
Mesopancreas Study in Pancreatic Cancer
After the Introduction of the pathological circumferential resection margin (CRM status by LEEPP Protocol), residual cancer (R1 resection) was most often found in the dorsal and medial resection margins.
- Conditions
- PDAC, Pancreatoduodenectomy, Margin, Resection, Surgery
- Trial name
- MESOPANC-01 (NCT05895214)
- Testing
- oncological relevance of the mesopancreas
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Artery Disease
Evaluation of PCD-CT Based Image Parameters in the Assessment and Quantification of Coronary Artery Disease
The goal of this observational study is to learn about a new type of computed tomography (Photon-Counting Detector CT) in patients with coronary artery disease.
- Trial name
- EPIPHANY (NCT05877768)
- Testing
- Photon Counting Detector Coronary Computed Tomography Angiography
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Medical Center Mainz
Myocardial Infarction, Myocardial Injury
Lymphatic Organs and Myocardium After Myocardial Infarction
The adaptive immune response plays an important role in myocardial healing and remodeling after acute myocardial infarction in patients. Therefore, the involved lymphocytes represent a novel target for therapeutic interventions.
- Conditions
- Myocardial Infarction, Myocardial Injury, Myocardial Inflammation
- Trial name
- LOMI (NCT05519735)
- Testing
- Multimodality Imaging
- Where
- 2 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Wuerzburg University Hospital
Acute Ischemic Stroke
Improving Low ASPECTS Stroke Thrombectomy
Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study.
- Trial name
- I-LAST (NCT04862507)
- Testing
- Telephone call on day 90, Quantification of lesion water uptake by CT densitometry
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Colon Carcinoma, Lymph Node Metastases
Lymph Node Mapping Via Flourescent Dye in Colon Cancer
The aim of the study is to evaluate whether lymph nodes draining the region of the carcinoma are located only inside the lines of standard resection or in some percentages are located outside as well.
- Trial name
- NCT04959604
- Testing
- ICG-marking endoscopically
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
BCR-ABL1-Negative Myeloid Neoplasms
German MPN-Registry for BCR-ABL 1-Negative Myeloid Neoplasms (Study Group Ulm)
To register a large number of patients with the diagnosis of a BCR-ABL 1- negative myeloid neoplasm (according to WHO 2008 / 2016 classification) in participating centers To store samples from all patients (e.g.
- Trial name
- NCT03125707
- Testing
- Registry study
- Where
- 30 sites in Germany
- Volunteers
- 2,172 people
- Sponsor
- University of Ulm