Clinical trials: active, in Ghana
Female Genital Schistosomiasis
A Phase III Trial to Evaluate the Safety and Efficacy of Anti-inflammatory Drugs in Addition to Praziquantel in Girls and Women With Female Genital Schistosomiasis
Female Genital Schistosomiasis (FGS) is a neglected complication of Schistosoma haematobium infection affecting an estimated 56 million women and girls globally, with a high burden in sub-Saharan Africa.
- Trial name
- WINGS-4-FGS (NCT07915518)
- Testing
- Praziquantel 80, Prednisolone, Diclofenac
- Where
- 4 sites in Côte d’Ivoire, Democratic Republic of the Congo and 2 more
- Volunteers
- 800 people
- Sponsor
- Brian Ngwira
Hypertension, Diabetes
Genetics of Type 2 Diabetes in West Africans
Background: Type 2 diabetes (T2D) and associated complications are major contributors to the global disease burden. T2D is already a major health threat in populations in developed countries and is rapidly taking hold in the…
- Trial name
- NCT00837122
- Where
- 5 sites in Ghana, Nigeria
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 163 people
- Sponsor
- University of California, San Francisco
Trauma, Appendectomy
Hospital Based Continuous Patient Monitoring System
In Ghana, and many other low and middle income countries in Africa, manual vital signs monitoring is the prevalent mode of vital signs monitoring because continuous bedside monitors are non-functional.
- Conditions
- Trauma, Appendectomy, Pediatric ALL, Vital Signs Monitoring
- Trial name
- NCT06739447
- Testing
- Consumer Wearable Device Vital Sign Measurement
- Where
- Ghana
- Volunteers
- 250 people
- Sponsor
- University of Alabama at Birmingham
Proteinuric Kidney Disease
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
- Trial name
- AMPLITUDE (NCT05312879)
- Testing
- VX-147
- Where
- 314 sites in United States, Belgium and 11 more
- Volunteers
- 522 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Lassa Fever
A Lassa Fever Vaccine Trial in Adults and Children Residing in West Africa
A Phase 2 Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults and Children Residing in West Africa
- Trial name
- NCT05868733
- Testing
- Day 1 Dose (2×106 pfu), Day 1 Dose (1×107 pfu), Day 1 Dose (2×10^5 pfu)
- Where
- 3 sites in Ghana, Liberia and 1 more
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Uncomplicated Plasmodium Falciparum Malaria
Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort C2)
This was Cohort C2 of the Platform study (NCT05750628) to evaluate the efficacy and safety of Cipargamin + KLU156 in participants with uncomplicated Plasmodium falciparum malaria.
- Trial name
- PLATINUM (NCT07811908)
- Testing
- KAE609, SoC (Coartem), KLU156
- Where
- 13 sites in Burkina Faso, Côte d’Ivoire and 5 more
- Volunteers
- 120 people
- Sponsor
- Novartis Pharmaceuticals
Sickle Cell Disease (SCD)
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients
The purpose of this study is to compare the efficacy and safety of 2 doses of crizanlizumab (5.0 mg/kg and 7.5 mg/kg) versus placebo in adolescent and adult sickle cell disease (SCD) patients with history of vaso-occlusive crisis…
- Trial name
- STAND (NCT03814746)
- Testing
- Crizanlizumab (SEG101)
- Where
- 58 sites in United States, Belgium and 19 more
- Volunteers
- 253 people
- Sponsor
- Novartis Pharmaceuticals
NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis
The purpose of this study is to assess the efficacy, safety, PK, and PD of satralizumab in participants with NMDAR and LGI1 encephalitis.
- Trial name
- Cielo (NCT05503264)
- Testing
- Satralizumab
- Where
- 56 sites in United States, Argentina and 13 more
- Volunteers
- 122 people
- Sponsor
- Hoffmann-La Roche
Unaccompanied Migration
Testing the Impact of Family-Based Intervention to Improve Developmental and Health Outcomes for Female Adolescents
This study seeks to address the urgent need for theoretically and empirically informed interventions that would address the increasing numbers of unaccompanied minors migrating from rural to urban centers in developing countries…
- Trial name
- NCT07278934
- Testing
- ANZANSI Family Program
- Where
- Ghana
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- New York University
Child Malnutrition
7-Day vs 1-Day Packaging for Small Quantity Lipid-Based Nutrient Supplements in Ghana (SQLNS:7D-1D Comparison)
This cluster-randomized crossover trial evaluates whether the packaging format of small-quantity lipid-based nutrient supplements (SQ-LNS) affects caregiver adherence and acceptability when SQ-LNS are delivered through routine…
- Trial name
- SQLNS:7Dv1D (NCT07129109)
- Testing
- small-quantity lipid-based nutrient supplements (SQ-LNS)
- Where
- Ghana
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Triple Negative Breast Cancer, Metastatic Triple-negative Breast Cancer
HEADWATERS: Gemcitabine vs Paclitaxel in Metastatic Triple-Negative Breast Cancer in Women of African Ancestry.
The goal of this clinical trial is to learn if Gemcitabine, a chemotherapy drug that is usually used to treat breast cancer after other treatments have failed, is better at treating triple negative breast cancer in women of…
- Trial name
- NCT07528768
- Testing
- Gemcitabine (1000 mg/m^2), Paclitaxel 80 mg/m2 weekly
- Where
- 3 sites in Barbados, Ghana and 1 more
- Volunteers
- 750 people
- Sponsor
- The University of The West Indies
Sickle Cell Disease, Thalassemia
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin.
- Trial name
- FLORAL (NCT06609226)
- Testing
- Etavopivat A, Etavopivat B, Etavopivat C
- Where
- 107 sites in United States, Canada and 15 more
- Volunteers
- 480 people
- Sponsor
- Novo Nordisk A/S
Sickle Cell Disease
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and adolescents living with sickle…
- Trial name
- Hibiscus 2 (NCT06612268)
- Testing
- Etavopivat
- Where
- 175 sites in United States, Australia and 19 more
- Volunteers
- 510 people
- Sponsor
- Novo Nordisk A/S
Heart Failure
30 Days and 90 Days Heart Failure Re-Admission at Komfo Anokye Teaching Hospital
In Ghana, about 88.3 per cent of cardiac admissions are due to Heart failure, making it the leading cause of admission due to heart conditions.
- Trial name
- HeFRA (NCT07100561)
- Testing
- Extensive post discharge counselling and phone-based follow up
- Where
- Ghana
- Volunteers
- 220 people
- Sponsor
- Komfo Anokye Teaching Hospital
Type 2 Diabetes, Hypertension
iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic Diseases
To provide real world data on patient characteristics, disease management, healthcare utilization, and outcomes in patients with type 2 diabetes, Hypertension, Heart failure and/or Chronic kidney diseases
- Conditions
- Type 2 Diabetes, Hypertension, Chronic Kidney Disease, Heart Failure
- Trial name
- iCaReMe (NCT03549754)
- Where
- 76 sites in Brazil, Chile and 18 more
- Volunteers
- 35,000 people
- Sponsor
- AstraZeneca
Sepsis
Development of Context-Adapted Quality Indicators for Early Sepsis Care in Sub-Saharan Africa - A Modified Delphi Consensus Procedure
The research project is an anonymous, prospective, non-interventional consensus study in the form of a modified Delphi method, consisting of three online surveys and structured feedback meetings without recording.
- Trial name
- NCT07711535
- Where
- Ghana
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Psychosis
Preliminary Efficacy of an mHealth Intervention in West Africa
The investigators are conducting a pilot feasibility and preliminary efficacy trial of a digital intervention for serious mental illness in West Africa.
- Trial name
- NCT07276321
- Testing
- G-FOCUS
- Where
- Ghana
- Volunteers
- 50 people
- Sponsor
- University of Washington
Snakebite, Snake Envenomation
Mapping Snakebite Risk in Ghana and Rwanda
Snakebite causes approximately 138,000 deaths each year and non-fatal bites lead to considerable health burden, particularly in low-income tropical countries. Data on snakebite burden are lacking.
- Trial name
- NCT06808789
- Where
- Ghana
- Volunteers
- 32,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Breast Cancer Screening
Evaluating Interventions for Breast Cancer Screening in Ghana
This study aims to implement two interventions to determine the most effective one that can improve Ghanaian women's decision to get their breasts examined by a healthcare professional.
- Trial name
- NCT07745517
- Testing
- Community Health Nurse-Led Breast Cancer Screening Education, Text Messaging Breast Cancer Screening Educational Intervention, Control Arm - standard of care
- Where
- Ghana
- Volunteers
- 828 people
- Sponsor
- University of Huddersfield