Clinical trials: in Guinea-Bissau
Tuberculosis, Tuberculosis, Pulmonary
Treating Tuberculosis Wasting With a High-protein Supplement
Undernutrition at the time of diagnosis of active tuberculosis is a risk factor for increased mortality, and lack of weight gain during anti-tuberculous treatment has been linked to an increased relapse risk.
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Undernutrition, Malnutrition
- Trial name
- NUTRIATO (NCT03302949)
- Testing
- Lacprodan® DI-8090
- Where
- Guinea-Bissau
- Volunteers
- 232 people
- Sponsor
- University of Aarhus
Underweight, Wasting
Preventing Infant Malnutrition With Early Supplementation
Background: Worldwide, more than 50 million children under 5 years of age are wasted (weight-for-length/height Z-score (WLZ) <-2) and over 150 million children under 5 are stunted (length/height-for-age Z-score (LAZ) <-2); such…
- Conditions
- Underweight, Wasting, Stunting, Breastfeeding
- Trial name
- PRIMES (NCT04704076)
- Testing
- ESVS, Exclusive breastfeeding
- Where
- 2 sites in Guinea-Bissau, Uganda
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Covid19, Morbidity
BCG to Reduce Absenteeism Among Health Care Workers During the COVID-19 Pandemic
The COVID-19 pandemic challenges available hospital capacity. Strategies to protect health care workers (HCW) are desperately needed.
- Conditions
- Covid19, Morbidity, Absenteeism
- Trial name
- EDCTP (NCT04641858)
- Testing
- BCG-Denmark, Saline
- Where
- 2 sites in Guinea-Bissau, Mozambique
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Malaria, Effectiveness
Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria
Objective: to measure the effectiveness and safety of (artemether-lumefantrine) AL and (dihydroartemisinin-piperaquine) DP in patients (> 6 months) suffering from uncomplicated P. falciparum malaria.
- Trial name
- NCT04897919
- Testing
- Dihydroartemisinin-piperaquine 160 mg/20 mg Oral Tablet, Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet
- Where
- Guinea-Bissau
- Volunteers
- 474 people
- Sponsor
- Bandim Health Project
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Overweight and Obesity, Weight Loss
Pilot Study on Weight Loss in Guinea Bissau
The purpose of this study is to test two versions a weight loss program potentially suitable for implementation in Africa. A successful method would have widespread application in low-income countries, with the potential to…
- Trial name
- NCT03316742
- Testing
- Intervention 1, Intervention 2
- Where
- Guinea-Bissau
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
COVID-19, Respiratory Illness
Locally Produced Cloth Face Mask and COVID-19 Like Illness Prevention
The number of cases of COVID-19 is still increasing and transmission of SARS-CoV-2 seems to occur mainly through person-to-person transmission through respiratory droplets, indirect contact with infected people and surfaces.
- Trial name
- NCT04471766
- Testing
- Certified cloth face mask plus preventive information, Preventive information
- Where
- Guinea-Bissau
- Volunteers
- 40,000 people
- Sponsor
- Bandim Health Project
Diarrhea
Etiology of Diarrhea in Guinea-Bissau and in Finland
Diarrhoea is the leading cause of death in the world with 2.2 million deaths every year. The majority of deaths are among children in developing countries, but the travellers encounter the disease as well.
- Trial name
- NCT01269554
- Where
- 3 sites in Finland, Guinea-Bissau
- Volunteers
- 920 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Malaria
Improving Anti-malarial Treatment Options in Guinea-Bissau - Part A
Plasmodium falciparum causes malaria and approximately 665 000 deaths each year. chloroquine and sulphadoxine-pyrimethamine resistant P. falciparum are widespread.
- Trial name
- NCT01704508
- Testing
- Artemether-lumefantrine, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 346 people
- Sponsor
- Bandim Health Project
Malaria
Artemether-Lumefantrine Effectiveness in Guinea-Bissau 2
The routine treatment of children with antimalarials will be monitored. Children with a positive malaria film and/or a positive rapid diagnostic test (RDT) will have a capillary blood sample taken to verify the diagnosis and to…
- Trial name
- NCT01133314
- Where
- Guinea-Bissau
- Volunteers
- 600 people
- Sponsor
- Bandim Health Project
Malaria
Artemether-Lumefantrine Effectiveness in Guinea-Bissau
The routine treatment of children with antimalarials will be monitored. Children with a positive malaria film and/or a positive rapid diagnostic test (RDT) will be included in a follow-up study.
- Trial name
- NCT01157689
- Where
- Guinea-Bissau
- Volunteers
- 500 people
- Sponsor
- Bandim Health Project
Stunting, Wasting
Weight Patterns in the Month After Birth
This is a prospective cohort study that will be conducted in four low income countries to describe newborn weight patterns in the first month after birth and their association with clinical and demographic factors including…
- Conditions
- Stunting, Wasting, Undernutrition, Feeding Patterns
- Trial name
- NCT04025827
- Testing
- Dietary intake
- Where
- 5 sites in United States, Guinea-Bissau and 3 more
- Volunteers
- 741 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Non Specific Effects of Vaccine, Bacillus-Calmette-Guerin
Low Birth Weight Follow-up
The Randomized Control Trail included 4,172 low-birth weight children between February 2008 and September 2013 in Bissau. The children who were included in the RCT and who are living in the Bandim Health Project study area will…
- Conditions
- Non Specific Effects of Vaccine, Bacillus-Calmette-Guerin, Low Birth Weight, Maternal Immunisation
- Trial name
- NCT03020147
- Where
- Guinea-Bissau
- Volunteers
- 1,258 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Innate Immunity, Bacille Calmette-Guérin
Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau
The propose is to test innate immune training in a pilot study of 40 adults >50 years of age people in Guinea-Bissau. The hypothesis is that BCG vaccination will be associated with increased innate immune training measured as…
- Trial name
- NCT02953327
- Testing
- Bacille Calmette-Guerin, BCG solvent
- Where
- Guinea-Bissau
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Mortality, Morbidity
Sex-Differential Health Interventions In Low-Birth-Weight Infants
Our group has consistently found that the major interventions to reduce morbidity and mortality in low-income countries have sex-differential effects.
- Conditions
- Mortality, Morbidity, Growth, Neonatal Mortality
- Trial name
- NCT00625482
- Testing
- OPV, OPV plus BCG
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Heterologous Immunity, Infant Morbidity
Comparing Morbidity and Mortality Effects of Two Different Strains of BCG
Background: Investigators at Bandim Health Project (BHP, www.bandim.org) in Guinea-Bissau have shown in several randomized trials that the Bacille-Calmette-Guérin (BCG) vaccine against tuberculosis (TB) is associated with reduced…
- Conditions
- Heterologous Immunity, Infant Morbidity, Infant Mortality, Trained Immunity
- Trial name
- NCT03400878
- Testing
- BCG-Japan, BCG-Russia
- Where
- 2 sites in Guinea-Bissau
- Volunteers
- 17,505 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Morbidity, Bacille Calmette-Guérin
Trial of Two Strains of BCG
The investigators aim to conduct a randomised controlled trial comparing two Bacille Calmette-Guérin (BCG) strains currently used in Guinea-Bissau, the Danish and the Russian, in terms of prevention of neonatal and early life…
- Trial name
- BCGSTRAIN (NCT02447536)
- Testing
- BCG-Denmark 1331 (Statens Serum Institute), BCG-Russia-I (Serum Institute of India)
- Where
- Guinea-Bissau
- Volunteers
- 12,006 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Malnutrition, Child, Cognitive Function
Locally Prepared Supplement to Support Growth and Brain Health
This study is a randomized controlled trial with a main goal to assess the effects of a locally-prepared food for prevention of malnutrition and stunting, in comparison with standard village practices and also a widely available…
- Trial name
- NCT03017209
- Testing
- Locally-prepared bar, USAID Corn Soy Blend Plus
- Where
- Guinea-Bissau
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tufts University
Early Neonatal Mortality
A Randomized Trial of Providing BCG Vaccination Immediately
Recent studies show that BCG vaccination reduces neonatal mortality by more than 40%. This effect cannot be explained by prevention of tuberculosis, which is very rare among infants.
- Trial name
- NCT01989026
- Testing
- BCG
- Where
- Guinea-Bissau
- Volunteers
- 3,361 people
- Sponsor
- Bandim Health Project
Per Capita Food Consumption Expenditure, Childhood Growth
Evaluation of a Cash Transfer Program in Low-Income Families in Guinea-Bissau
This pilot study will test the effect of a cash transfer program aiming to improve family food consumption patterns, family health and schooling, with resulting benefits for childhood growth and cognition.
- Conditions
- Per Capita Food Consumption Expenditure, Childhood Growth, Childhood Cognition, Anemia
- Trial name
- NCT03455257
- Testing
- Cash Transfer
- Where
- Guinea-Bissau
- Volunteers
- 34,148 people
- Sponsor
- Ministry of Finance, Guinea-Bissau