Clinical trials: in Guinea-Bissau
Hospital Mortality, Malaria
Evaluation of Local Mechanisms for Staff Motivation to Reduce Hospital Mortality
We observed in a randomised intervention trial in Bissau that mortality due to malaria could be reduced by half by adding a small monetary incentive to the staff and strict follow-up of a standard protocol for available drugs.
- Trial name
- NCT00673166
- Testing
- Staff incentive & supervision, Staff motivation
- Where
- Guinea-Bissau
- Volunteers
- 900 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Bacillus Calmette-Guerin (BCG) Vaccine and Morbidity From Malaria
BCG vaccine is given at or shortly after birth in many developing countries to prevent tuberculosis. In Guinea Bissau, it has been shown that its protective effect against death is greater than would be expected from its effect…
- Trial name
- NCT00131794
- Testing
- BCG
- Where
- Guinea-Bissau
- Volunteers
- 1,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Measles
mHealth to Increase Measles Immunization - a Randomized Controlled Trial in Guinea-Bissau
The question that this project seeks to answer, is whether mobile phones can be used to increase the measles vaccination coverage and timeliness in Guinea-Bissau.
- Trial name
- mimi (NCT02662595)
- Testing
- SMS reminder message, Voice call + SMS message
- Where
- 3 sites in Guinea-Bissau
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
HIV-1
PI or NNRTI as First-line Treatment of HIV in West Africa - the PIONA Trial
BACKGROUND: Since 1996 the combination of three or more drugs has been the mainstay of human immunodeficiency virus (HIV) treatment.
- Trial name
- PIONA (NCT01192035)
- Testing
- Efavirenz or Nevirapine, Ritonavir-boosted lopinavir
- Where
- Guinea-Bissau
- Volunteers
- 400 people
- Sponsor
- University of Aarhus
Malaria
Pharmacokinetic Study of Multi-dose Chloroquine
Chloroquine (CQ) remains an alternative cheap, safe and widely available drug. Our previous research has shown that double (50 mg/kg) standard dose CQ given in split doses had a 95% efficacy and was well tolerated and safe.
- Trial name
- NCT01814423
- Testing
- Chloroquine-base 50 mg, Chloroquine-base 70 mg
- Where
- Guinea-Bissau
- Volunteers
- 30 people
- Sponsor
- Bandim Health Project
Pregnancy, Birth Weight
Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome
Prenatal maternal micronutrient supplementation has been suggested as a means to reduce the proportion of low birth weight babies in low-income countries.
- Trial name
- NCT00168688
- Testing
- multi micronutrient supplement, MN1, MN2
- Where
- Guinea-Bissau
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Mortality, Morbidity
Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity
Vitamin A supplementation (VAS) is important for the immune system and may interact with different childhood vaccinations. We have hypothesized that the improved survival after VAS may depend on vitamin A amplifying the…
- Trial name
- NCT00168623
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 6,200 people
- Sponsor
- Bandim Health Project
Measles Infection
Additional Measles Vaccine at 4 Months of Age
Overall objective: To conduct a randomised controlled trial (RCT) to examine whether an early two-dose measles vaccination (MV) strategy at 4 and 9 months will reduce child mortality compared with the WHO strategy of one dose of…
- Trial name
- NCT01486355
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Mortality, Morbidity
Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality
We previously compared the effect on mortality of the half dose and the full dose currently recommended by WHO. Unexpectedly, the low dose was clearly better for girls, but not for boys.
- Trial name
- NCT00168636
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 11,000 people
- Sponsor
- Bandim Health Project
Atopy, Asthma
Vitamin A Supplementation at Birth and Atopy in Childhood
INTRODUCTION Eight trials studying the effect of providing neonatal vitamin A supplementation (NVAS) have been reported, and another four are underway to test whether NVAS should become WHO policy.
- Conditions
- Atopy, Asthma, Eczema, Food Allergy
- Trial name
- NCT01779180
- Where
- Guinea-Bissau
- Volunteers
- 2,000 people
- Sponsor
- Bandim Health Project
Mortality, Morbidity
Vitamin A With BCG Vaccine
Two studies from Asia have suggested a beneficial effect of vitamin A supplementation given at birth. Hypotheses: Vitamin A supplementation administered at birth together with BCG vaccination is associated with a 30% reduction in…
- Trial name
- NCT00168597
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 4,800 people
- Sponsor
- Bandim Health Project
Infant Mortality, Morbidity
Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine
In the present study the investigators wish to address the effects of different doses of vitamin A supplementation in low and normal birth weight infants.
- Trial name
- NCT00168610
- Testing
- Vitamin A
- Where
- Guinea-Bissau
- Volunteers
- 7,600 people
- Sponsor
- Bandim Health Project
Infant, Newborn, Healthy
Investigating the Mortality and the Morbidity Impact of Oral Polio Vaccine at Birth
Our group has discovered that routine vaccinations in childhood may have non-specific and sex-differential effects on overall mortality.
- Trial name
- NCT00710983
- Testing
- Oral polio vaccine
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project
Aids, Cdc Group I
HIV-1 Peptide Immunisation of Individuals in West Africa to Prevent Disease
Treatment: Immunization with peptide-mix and adjuvant. The vaccine should induce cellular immunity against HIV-1. Target group: Untreated healthy individuals with chronic HIV-1 infection.
- Trial name
- HIV-BIS (NCT01141205)
- Testing
- AFO-18, Saline
- Where
- 2 sites in Guinea-Bissau
- Volunteers
- 18 people
- Sponsor
- Statens Serum Institut
Tuberculosis
Should Low Birth Weight Infants Be Vaccinated With BCG Vaccine at Birth in Developing Countries?
The World Health Organization (WHO) currently recommends BCG vaccination at birth in developing countries. Pre-term infants should be vaccinated when they reach the chronological age of 40 weeks.
- Trial name
- NCT00146302
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,320 people
- Sponsor
- Bandim Health Project
Measles
Early Two-dose Measles Vaccination Trial
The specific aims are to examine in Guinea-Bissau: whether the standard titre Schwarz (SW) or standard-titre Edmonston-Zagreb (EZ) measles vaccine will be the best vaccine strain for use in a routine one-dose measles vaccination…
- Trial name
- NCT00168558
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Volunteers
- 5,879 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Mortality, Hospitalization
Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination
In non-randomized studies, routine childhood vaccinations have been observed to have non-targeted effects. Difteria-tetanus-pertussis (DTP) vaccine provided with or after measles vaccine (MV) is associated with increased…
- Conditions
- Mortality, Hospitalization, Adverse Events
- Trial name
- NCT00244673
- Testing
- DTP3/4+OPV+MV versus OPV+MV or DTP4+OPV4 versus OPV4
- Where
- Guinea-Bissau
- Volunteers
- 6,534 people
- Sponsor
- Bandim Health Project
Asthma, Eczema
Bacille Calmette-Guérin (BCG) Vaccine and Atopy
The prevalence of asthma and allergic diseases is increasing worldwide. Infections and vaccinations in childhood may have an impact on the subsequent development of asthma and allergy.
- Conditions
- Asthma, Eczema, Food Hypersensitivity
- Trial name
- NCT01420705
- Where
- Guinea-Bissau
- Volunteers
- 487 people
- Sponsor
- Bandim Health Project
Measles
Long-term Follow-up of Measles Antibodies
Few data exist on long-term persistence of measles antibodies after vaccination of West African infants. The data that do exist indicate that the antibody titres decline very rapidly.
- Trial name
- NCT00168571
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Volunteers
- 1,960 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Measles, Diphtheria
Immunology of Non-specific Effects of Vaccine
OBJECTIVES General: To investigate the immunological background for the non-specific effects of diphtheria-tetanus-pertussis (DTP) and measles vaccines on child mortality Specific: Examine the cytokine responses and possible…
- Conditions
- Measles, Diphtheria, Tetanus, Pertussis
- Trial name
- NCT00168545
- Testing
- Measles vaccine
- Where
- Guinea-Bissau
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project