Clinical trials: in India
Sickle Cell Disease
Research Study Investigating How Well NDec Works in People With Sickle Cell Disease
This study examines how well a new, potential medicine called NDec works and is tolerated in people with sickle cell disease. NDec is a combination of two medicines (decitabine-tetrahydrouridine).
- Trial name
- ASCENT1 (NCT05405114)
- Testing
- NDec - oral decitabine-tetrahydrouridine, HU - Hydroxyurea
- Where
- 118 sites in United States, Canada and 12 more
- Volunteers
- 96 people
- Sponsor
- Novo Nordisk A/S
Cancer of Prostate, Cancer Head Neck
ARCHERY - Artificial Intelligence Based Radiotherapy Treatment Planning for Cervical, Head and Neck and Prostate Cancer
The aim of this study is to look at whether an Artificial Intelligence (AI) based computer program can automate two components of the radiotherapy treatment pathway to a sufficient quality standard to enable its routine clinical…
- Conditions
- Cancer of Prostate, Cancer Head Neck, Cancer Cervix
- Trial name
- NCT05653063
- Testing
- A web-based artificial intelligence (AI) auto-planning tool
- Where
- 6 sites in India, Jordan and 2 more
- Volunteers
- 1,029 people
- Sponsor
- University College, London
HIV Infections, Weight Gain
Optimising Metabolic Management for People With Human Immunodeficiency Virus (HIV) on Integrase Based Antiretroviral Therapy (ART)
People with HIV are at a higher risk of cardiovascular diseases (CVD) due to the effects of the virus and its treatment. Integrase strand transfer inhibitors (INSTIs), a common HIV treatment, are associated with increased CVD…
- Trial name
- OPTIMAR (NCT06317051)
- Testing
- Dapagliflozin 10mg Tab, Pitavastatin 4 Mg Oral Tablet, Rosuvastatin and Ezetimibe
- Where
- 10 sites in Argentina, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- Kirby Institute
SLE
Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythematosus
The purpose of this study is to assess the clinical efficacy, safety, PK, and PD of multiple dose levels of ESK-001 compared with placebo in adult patients with SLE.
- Trial name
- LUMUS (NCT05966480)
- Testing
- Envudeucitinib
- Where
- 169 sites in United States, Argentina and 19 more
- Volunteers
- 408 people
- Sponsor
- Alumis Inc
Alcoholic Hepatitis
Efficacy Of Bovine Colostrum In The Treatment Of Severe Alcohol-Associated Hepatitis: A Randomized Controlled Trial
Severe alcohol-associated hepatitis (sAH)is associated with hepatocellular necrosis, inflammation, hyperactivated immune system, paradoxical immune exhaustion, leaky gut, and alteration in the gut microbiome.
- Trial name
- BASH (NCT02473341)
- Testing
- Bovine Colostrum
- Where
- 5 sites in India
- Volunteers
- 174 people
- Sponsor
- Dayanand Medical College and Hospital
Lung Cancer, Non-Small Cell
A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)
The goal of this clinical trial is to evaluate the safety and tolerability profile of dostarlimab in combination with belrestotug when compared with pembrolizumab and placebo in participants with previously untreated…
- Trial name
- NCT06472076
- Testing
- Dostarlimab, Belrestotug, Pembrolizumab
- Where
- 108 sites in United States, Argentina and 19 more
- Volunteers
- 88 people
- Sponsor
- GlaxoSmithKline
Early Childhood Caries (ECC)
Aesthetic and Functional Evaluation of a Universal One-Shade Composite in Primary Maxillary Incisors
Use of tooth-coloured fillings is an essential part of Pediatric dentistry as most patients desire fillings which look like natural teeth.
- Trial name
- NCT07716033
- Testing
- Tokuyama Palfique Omnichroma composite restoration, 3M Filtek Z350 composite restoration
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Goa Dental College
Epithelial Ovarian Cancer
AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer
The intention of the study is to demonstrate superiority of AZD5335 versus standard of care by assessment of progression-free survival (PFS) in women with high-grade, platinum-resistant epithelial ovarian, fallopian tube, or…
- Trial name
- TREVI-OC-01 (NCT07218809)
- Testing
- AZD5335, Mirvetuximab Soravtansine (MIRV), Paclitaxel
- Where
- 299 sites in United States, Australia and 22 more
- Volunteers
- 1,100 people
- Sponsor
- AstraZeneca
Chronic Liver Disease and Cirrhosis
Influence of Donor and Recipient Genetic Polymorphisms on Graft Steatosis After Liver Transplant
MASH (Metabolic Dysfunction-associated Steatohepatitis) is among the most common indications for liver transplantation.The metabolic syndrome persists after liver transplant and is often further exacerbated among MAFLD patients…
- Trial name
- NCT07685353
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gestational Diabetes Mellitus (GDM)
Assessment of Quality of Life and Psychological Factors Among Women Diagnosed With Gestational Diabetes Mellitus
Summary of Research Protocol Title: Quality of Life and Associated Psychological Factors in Women with Gestational Diabetes Mellitus Background: Gestational Diabetes Mellitus (GDM) is a common metabolic disorder of pregnancy…
- Trial name
- NCT07717424
- Where
- India
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Lovely Professional University
Non-hepatobiliary Indications
EUS-Guided ATI and SWE in Individuals With Normal FibroScan
The goal of this observational study is to establish preliminary reference values for Endoscopic Ultrasound (EUS)-guided Attenuation Imaging (ATI) and Shear Wave Elastography (SWE) in adults undergoing diagnostic EUS for…
- Trial name
- EUS ATI&SWE (NCT07714941)
- Testing
- Endoscopic Ultrasound (EUS), EUS-guided Attenuation Imaging (ATI), EUS-Guided Shear Wave Elastography (SWE)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Multiple Sclerosis
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
The purpose of each study is to independently measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of teriflunomide in male and female participants with relapsing forms of…
- Trial name
- FREXALT (NCT06141473)
- Testing
- Frexalimab, Teriflunomide, MRI contrast-enhancing agents
- Where
- 382 sites in United States, Argentina and 39 more
- Volunteers
- 1,655 people
- Sponsor
- Sanofi
Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications
Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative…
- Conditions
- Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications, Donor Hepatectomy
- Trial name
- NCT07715500
- Testing
- Magnetic Resonance Cholangiopancreatography
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gaucher Disease Type 3
Study to Evaluate the Efficacy and Safety of Nizubaglustat (AZ-3102) in Patients With Gaucher Disease Type 3 (GD3)
A 96-week, open-label, Phase 2 study to evaluate the efficacy and safety of Nizubaglustat (AZ-3102) in patients with Gaucher disease type 3 (GD3).
- Trial name
- NCT07715084
- Testing
- AZ-3102
- Where
- 7 sites in India, Pakistan and 1 more
- Volunteers
- 20 people
- Sponsor
- Azafaros B.V.
Chronic Obstructive Pulmonary Disease
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
The purpose of this study is to assess the efficacy and safety of verekitug (UPB-101) in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), an inflammatory lung disease.
- Trial name
- NCT06981078
- Testing
- Verekitug
- Where
- 242 sites in United States, Argentina and 21 more
- Volunteers
- 666 people
- Sponsor
- Upstream Bio Inc.
Bullous Keratopathy, Corneal Endothelial Dystrophy
Simple Non-cultured Endothelial Cell Therapy for Corneal Endothelial Dysfunction
Assessment of safety and efficacy of cell injection therapy generated using non-cultured human corneal endothelial cells in treating corneal endothelial dysfunction
- Trial name
- NCT07711561
- Testing
- Cell injection
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Singapore Eye Research Institute
Moderate to Severe Ulcerative Colitis
A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis
This phase 2b study is designed to have all subjects go into a 12 week induction period to compare different doses of study drug against placebo.
- Trial name
- NCT04090411
- Testing
- Induction- PF-06480605 50 mg SC Q4W, Induction- PF-06480605 150 mg SC Q4W, Induction- PF-06480605 450 mg SC Q4W
- Where
- 166 sites in United States, Australia and 21 more
- Volunteers
- 246 people
- Sponsor
- Hoffmann-La Roche
Granulomatosis With Polyangiitis (Wegener's)
Assessing Granulomatosis With Polyangiitis Activity: 18F-FDG PET/CT vs BVAS v3
The goal of this observational study is to quantify activity and extent of disease in patients with GPA using 18F-FDG PET/CT. The main questions it aims to answer are: Sensitivity of 18 F-FDG PET/CT in patients with GPA?…
- Trial name
- NCT07712172
- Testing
- 18F-FDG, 18F-FDG PET/CT
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Subdural Hematoma
Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH)
This study is an open label randomized controlled trial. Patients with a symptomatic Chronic Subdural Hematoma (CSDH) confirmed on radiological imaging, planned for surgery, age over 18, free from other intracranial pathologies…
- Trial name
- RATATA (NCT07245264)
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- India
- Volunteers
- 274 people
- Sponsor
- St. Olavs Hospital
Dental Crowding, Smile Arc Correction
A Study to Evaluate the Relationship Between Two Bracket System and Their Contribution to Initial Alignment of Maxillary Anteriors - De Crowding, Smile Arc Protection.
The goal of this clinical trial is to compare the two orthodontic bracket systems namely MBT and the Pitts21 for maxillary anterior decrowding, initial alignment as well as the smile arc correction in 6 month period.
- Conditions
- Dental Crowding, Smile Arc Correction, Maxillary Crowded Teeth
- Trial name
- NCT07712055
- Testing
- Pitts 21 bracket system, MBT bracket system
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Srinivas College of Dental Sciences
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